Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00344"

Predicate	Value (sorted: default)
rdfs:label	"Protriptyline"
rdf:type	ns1:drugs
ns1:description	"Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression. "
ns1:drugCategory	?:Adrenergic Uptake Inhibitors ?:Antidepressive Agents, Tricyclic
ns1:interactsWith	?:Fluvoxamine ?:Tramadol ?:Trospium ?:Butabarbital ?:Butalbital ?:Ziprasidone ?:Venlafaxine ?:Zolmitriptan ?:Terfenadine ?:Grepafloxacin ?:Tacrine ?:Phenylephrine ?:Phenylpropanolamine ?:Triprolidine ?:Fluoxetine ?:Cimetidine ?:Toremifene ?:Clonidine ?:Voriconazole ?:Cisapride ?:Rifabutin ?:Trazodone ?:Trimethobenzamide ?:Epinephrine ?:Galantamine ?:Trimipramine ?:Tranylcypromine ?:Phenelzine ?:Orciprenaline ?:Donepezil ?:Pseudoephedrine ?:Terbinafine ?:Tacrolimus ?:Terbutaline ?:Quinidine ?:Rifampicin ?:Atazanavir ?:Guanethidine ?:Moclobemide ?:Isocarboxazid ?:Fenoterol ?:Rasagiline ?:Thiothixene ?:Zuclopenthixol ?:Vorinostat ?:Artemether ?:Desvenlafaxine ?:Lumefantrine ?:Zuclopenthixol acetate ?:Zuclopenthixol decanoate
owl:sameAs	?:APRD00441 ?:Fluvoxamine ?:Tramadol ?:Trospium ?:Butabarbital ?:Butalbital ?:Ziprasidone ?:Venlafaxine ?:Zolmitriptan ?:Terfenadine ?:Grepafloxacin ?:Tacrine ?:Phenylephrine ?:Phenylpropanolamine ?:Triprolidine ?:Fluoxetine ?:Cimetidine ?:Toremifene ?:Clonidine ?:Voriconazole ?:Cisapride ?:Rifabutin ?:Trazodone ?:Trimethobenzamide ?:Epinephrine ?:Galantamine ?:Trimipramine ?:Tranylcypromine ?:Phenelzine ?:Orciprenaline ?:Donepezil ?:Pseudoephedrine ?:Terbinafine ?:Tacrolimus ?:Terbutaline ?:Quinidine ?:Rifampicin ?:Atazanavir ?:Guanethidine ?:Moclobemide ?:Isocarboxazid ?:Fenoterol ?:Rasagiline ?:Thiothixene ?:Zuclopenthixol ?:Vorinostat ?:Artemether ?:Desvenlafaxine ?:Lumefantrine ?:Zuclopenthixol acetate ?:Zuclopenthixol decanoate

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

The resource appears as object in 100 triples

Context graph