Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00381"

No prefix for http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/.
PredicateValue (sorted: default)
rdfs:label
"Amlodipine"
rdf:type
ns1:drugs
ns1:description
"Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina. "
ns1:drugCategory
?:Antianginal Agents
?:Antihypertensive Agents
?:Calcium Channel Blockers
?:Vasodilator Agents
ns1:interactsWith
?:Diltiazem
?:Treprostinil
?:Tacrine
?:Voriconazole
?:Thiopental
?:Tizanidine
?:Tipranavir
?:Telithromycin
?:Quinupristin
?:Telaprevir
owl:sameAs
?:APRD00520
?:Diltiazem
?:Treprostinil
?:Tacrine
?:Voriconazole
?:Thiopental
?:Tizanidine
?:Tipranavir
?:Telithromycin
?:Quinupristin
?:Telaprevir
?:DBSALT001054
?:DBSALT001055
?:DBSALT001056

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

The resource appears as object in 20 triples

Context graph