Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01115"
Predicate | Value (sorted: default) |
---|---|
rdfs:label |
"Nifedipine"
|
rdf:type | |
ns1:description |
"Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina."
|
ns1:drugCategory | |
ns1:interactsWith | |
owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt
The resource appears as object in 73 triples