Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01124"

No prefix for http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/.
PredicateValue (sorted: default)
rdfs:label
"Tolbutamide"
rdf:type
ns1:drugs
ns1:description
"Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces. "
ns1:drugCategory
?:Antidiabetic Agents
?:Hypoglycemic Agents
ns1:interactsWith
?:Somatropin recombinant
?:Esmolol
?:Fluconazole
?:Torasemide
?:Glimepiride
?:Dapsone
?:Phenytoin
?:Sulfisoxazole
?:Metoprolol
?:Floxuridine
?:Indomethacin
?:Atenolol
?:Sulfadiazine
?:Timolol
?:Digoxin
?:Trimethoprim
?:Chloramphenicol
?:Montelukast
?:Fluoxetine
?:Celecoxib
?:Fluorouracil
?:Zafirlukast
?:Piroxicam
?:Bosentan
?:Propranolol
?:Voriconazole
?:Labetalol
?:Bisoprolol
?:Nicardipine
?:Clofibrate
?:Tamoxifen
?:Losartan
?:Warfarin
?:Delavirdine
?:Flurbiprofen
?:Nateglinide
?:Mefenamic acid
?:Phenylbutazone
?:Acetylsalicylic acid
?:Pindolol
?:Sulfamethoxazole
?:Ketoconazole
?:Rifampicin
?:Ibuprofen
?:Glipizide
?:Capecitabine
?:Miconazole
?:Carvedilol
?:Sulfinpyrazone
?:Acebutolol
?:Zopiclone
?:Nadolol
?:Ketamine
?:Paclitaxel
?:Gemfibrozil
?:Lumiracoxib
?:Fosphenytoin
?:Mestranol
?:Acenocoumarol
?:Oxprenolol
?:Sitaxentan
owl:sameAs
?:APRD00267
?:BE0002793
?:BE0003536
?:Somatropin recombinant
?:Esmolol
?:Fluconazole
?:Torasemide
?:Glimepiride
?:Dapsone
?:Phenytoin
?:Sulfisoxazole
?:Metoprolol
?:Floxuridine
?:Indomethacin
?:Atenolol
?:Sulfadiazine
?:Timolol
?:Digoxin
?:Trimethoprim
?:Chloramphenicol
?:Montelukast
?:Fluoxetine
?:Celecoxib
?:Fluorouracil
?:Zafirlukast
?:Piroxicam
?:Bosentan
?:Propranolol
?:Voriconazole
?:Labetalol
?:Bisoprolol
?:Nicardipine
?:Clofibrate
?:Tamoxifen
?:Losartan
?:Warfarin
?:Delavirdine
?:Flurbiprofen
?:Nateglinide
?:Mefenamic acid
?:Phenylbutazone
?:Acetylsalicylic acid
?:Pindolol
?:Sulfamethoxazole
?:Ketoconazole
?:Rifampicin
?:Ibuprofen
?:Glipizide
?:Capecitabine
?:Miconazole
?:Tolbutamide
?:Carvedilol
?:Sulfinpyrazone
?:Acebutolol
?:Zopiclone
?:Nadolol
?:Ketamine
?:Paclitaxel
?:Gemfibrozil
?:Lumiracoxib
?:Fosphenytoin
?:Mestranol
?:Acenocoumarol
?:Oxprenolol
?:Sitaxentan
?:DBMET00289

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

The resource appears as object in 123 triples

Context graph