Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01142"

Predicate	Value (sorted: default)
rdfs:label	"Doxepin"
rdf:type	ns1:drugs
ns1:description	"Doxepin hydrochloride is a dibenzoxepin-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation. In depressed individuals, doxepin exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as doxepin and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Doxepin has less sedative and anticholinergic effects than amitriptyline. See toxicity section below for a complete listing of side effects. Doxepin may be used to treat depression and insomnia. Unlabeled indications include chronic and neuropathic pain, and anxiety. Doxepin may also be used as a second line agent to treat idiopathic urticaria. "
ns1:drugCategory	?:Adrenergic Uptake Inhibitors ?:Antidepressive Agents
ns1:interactsWith	?:Fluvoxamine ?:Tramadol ?:Trospium ?:Butabarbital ?:Butalbital ?:Ziprasidone ?:Venlafaxine ?:Zolmitriptan ?:Terfenadine ?:Grepafloxacin ?:Norepinephrine ?:Tacrine ?:Phenylephrine ?:Phenylpropanolamine ?:Triprolidine ?:Fluoxetine ?:Altretamine ?:Cimetidine ?:Ritonavir ?:Toremifene ?:Carbamazepine ?:Clonidine ?:Voriconazole ?:Cisapride ?:Metaraminol ?:Rifabutin ?:Trazodone ?:Trimethobenzamide ?:Epinephrine ?:Galantamine ?:Thioridazine ?:Methoxamine ?:Trimipramine ?:Thiabendazole ?:Tranylcypromine ?:Phenelzine ?:Orciprenaline ?:Dobutamine ?:Donepezil ?:Pseudoephedrine ?:Terbinafine ?:Tacrolimus ?:Terbutaline ?:Quinidine ?:Mesoridazine ?:Telithromycin ?:Dopamine ?:Rivastigmine ?:Salbutamol ?:Rifampicin ?:Isoprenaline ?:Atazanavir ?:Sibutramine ?:Guanethidine ?:Moclobemide ?:Sparfloxacin ?:Isocarboxazid ?:Fenoterol ?:Pirbuterol ?:Dihydroquinidine barbiturate ?:Quinidine barbiturate ?:Ephedra ?:Ephedrine ?:Mephentermine ?:Procaterol ?:Rasagiline ?:Thiothixene ?:Zuclopenthixol ?:Vorinostat ?:Artemether ?:Desvenlafaxine ?:Lumefantrine ?:Zuclopenthixol acetate ?:Zuclopenthixol decanoate
owl:sameAs	?:APRD00398 ?:BE0002363 ?:BE0002433 ?:BE0002638 ?:BE0002793 ?:BE0003536 ?:Fluvoxamine ?:Tramadol ?:Trospium ?:Butabarbital ?:Butalbital ?:Ziprasidone ?:Venlafaxine ?:Zolmitriptan ?:Terfenadine ?:Grepafloxacin ?:Norepinephrine ?:Tacrine ?:Phenylephrine ?:Phenylpropanolamine ?:Triprolidine ?:Fluoxetine ?:Altretamine ?:Cimetidine ?:Ritonavir ?:Toremifene ?:Carbamazepine ?:Clonidine ?:Voriconazole ?:Cisapride ?:Metaraminol ?:Rifabutin ?:Trazodone ?:Trimethobenzamide ?:Epinephrine ?:Galantamine ?:Thioridazine ?:Methoxamine ?:Trimipramine ?:Thiabendazole ?:Tranylcypromine ?:Phenelzine ?:Orciprenaline ?:Dobutamine ?:Donepezil ?:Pseudoephedrine ?:Terbinafine ?:Tacrolimus ?:Terbutaline ?:Quinidine ?:Mesoridazine ?:Telithromycin ?:Dopamine ?:Rivastigmine ?:Salbutamol ?:Rifampicin ?:Isoprenaline ?:Atazanavir ?:Sibutramine ?:Doxepin ?:Guanethidine ?:Moclobemide ?:Sparfloxacin ?:Isocarboxazid ?:Fenoterol ?:Pirbuterol ?:Dihydroquinidine barbiturate ?:Quinidine barbiturate ?:Ephedra ?:Ephedrine ?:Mephentermine ?:Procaterol ?:Rasagiline ?:Thiothixene ?:Zuclopenthixol ?:Vorinostat ?:Artemether ?:Desvenlafaxine ?:Lumefantrine ?:Zuclopenthixol acetate ?:Zuclopenthixol decanoate ?:DBMET00315 ?:DBMET00834 ?:DBMET00844 ?:DBMET00845 ?:DBMET00872 ?:DBMET00873 ?:DBMET00875 ?:DBMET00876 ?:DBMET00877 ?:DBMET00878 ?:DBMET00879 ?:DBMET00881 ?:DBSALT000059

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

The resource appears as object in 149 triples

Context graph