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PredicateValue (sorted: none)
rdf:type
ns1:drugs
owl:sameAs
?:EXPT02137
rdfs:label
"1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid"
ns1:description
" experimental This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at his terminal nitrogen atom. N-acyl-alpha Amino Acids Organic Compounds Organic Acids and Derivatives Carboxylic Acids and Derivatives Amino Acids, Peptides, and Analogues Pyrrolidine Carboxylic Acids Tertiary Carboxylic Acid Amides Tertiary Amines Polyamines Enolates Carboxylic Acids Alkylthiols pyrrolidine carboxylic acid or derivative pyrrolidine carboxylic acid tertiary carboxylic acid amide pyrrolidine carboxamide group tertiary amine alkylthiol polyamine enolate carboxylic acid amine organonitrogen compound logP 1.02 ALOGPS logS -1.7 ALOGPS Water Solubility 4.52e+00 g/l ALOGPS logP 0.73 ChemAxon IUPAC Name (2S)-1-[(2R)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid ChemAxon Traditional IUPAC Name (2S)-1-[(2R)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid ChemAxon Molecular Weight 217.285 ChemAxon Monoisotopic Weight 217.077264041 ChemAxon SMILES [H][C@](C)(CS)C(=O)N1CCC[C@@]1([H])C(O)=O ChemAxon Molecular Formula C9H15NO3S ChemAxon InChI InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7-/m0/s1 ChemAxon InChIKey InChIKey=FAKRSMQSSFJEIM-BQBZGAKWSA-N ChemAxon Polar Surface Area (PSA) 57.61 ChemAxon Refractivity 54.63 ChemAxon Polarizability 22.09 ChemAxon Rotatable Bond Count 3 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 4.02 ChemAxon pKa (strongest basic) -1.2 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon PubChem Compound 688267 PubChem Substance 46505775 ChemSpider 599746 BindingDB 50140754 PDB MCO BE0000221 Angiotensin-converting enzyme Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Angiotensin-converting enzyme Involved in metallopeptidase activity Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator ACE 17q23.3 Cell membrane; single-pass type I membrane protein. Processed form:Secreted protein. A soluble form 1260-1276 6.36 149716.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:2707 GenAtlas ACE GeneCards ACE GenBank Gene Database J04144 GenBank Protein Database 178286 UniProtKB P12821 UniProt Accession ACE_HUMAN Angiotensin-converting enzyme, somatic isoform precursor CD143 antigen Dipeptidyl carboxypeptidase I EC 3.4.15.1 Kininase II >Angiotensin-converting enzyme, somatic isoform precursor MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQV LFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRI IGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSR SYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDL EHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPF PDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCH ASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAI GDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFS GRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQF HEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLL KYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTS QVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRI IKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKY EDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLER LFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPS APSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHAS AWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGD VLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGS ITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHE ALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSY FKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQW LLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS >3921 bp ATGGGGGCCGCCTCGGGCCGCCGGGGGCCGGGGCTGCTGCTGCCGCTGCCGCTGCTGTTG CTGCTGCCGCCGCAGCCCGCCCTGGCGTTGGACCCCGGGCTGCAGCCCGGCAACTTTTCT GCTGACGAGGCCGGGGCGCAGCTCTTCGCGCAGAGCTACAACTCCAGCGCCGAACAGGTG CTGTTCCAGAGCGTGGCCGCCAGCTGGGCGCACGACACCAACATCACCGCGGAGAATGCA AGGCGCCAGGAGGAAGCAGCCCTGCTCAGCCAGGAGTTTGCGGAGGCCTGGGGCCAGAAG GCCAAGGAGCTGTATGAACCGATCTGGCAGAACTTCACGGACCCGCAGCTGCGCAGGATC ATCGGAGCTGTGCGAACCCTGGGCTCTGCCAACCTGCCCCTGGCTAAGCGGCAGCAGTAC AACGCCCTGCTAAGCAACATGAGCAGGATCTACTCCACCGCCAAGGTCTGCCTCCCCAAC AAGACTGCCACCTGCTGGTCCCTGGACCCAGATCTCACCAACATCCTGGCTTCCTCGCGA AGCTACGCCATGCTCCTGTTTGCCTGGGAGGGCTGGCACAACGCTGCGGGCATCCCGCTG AAACCGCTGTACGAGGATTTCACTGCCCTCAGCAATGAAGCCTACAAGCAGGACGGCTTC ACAGACACGGGGGCCTACTGGCGCTCCTGGTACAACTCCCCCACCTTCGAGGACGATCTG GAACACCTCTACCAACAGCTAGAGCCCCTCTACCTGAACCTCCATGCCTTCGTCCGCCGC GCACTGCATCGCCGATACGGAGACAGATACATCAACCTCAGGGGACCCATCCCTGCTCAT CTGCTGGGAGACATGTGGGCCCAGAGCTGGGAAAACATCTACGACATGGTGGTGCCTTTC CCAGACAAGCCCAACCTCGATGTCACCAGTACTATGCTGCAGCAGGGCTGGAACGCCACG CACATGTTCCGGGTGGCAGAGGAGTTCTTCACCTCCCTGGAGCTCTCCCCCATGCCTCCC GAGTTCTGGGAAGGGTCGATGCTGGAGAAGCCGGCCGACGGGCGGGAAGTGGTGTGCCAC GCCTCGGCTTGGGACTTCTACAACAGGAAAGACTTCAGGATCAAGCAGTGCACACGGGTC ACGATGGACCAGCTCTCCACAGTGCACCATGAGATGGGCCATATACAGTACTACCTGCAG TACAAGGATCTGCCCGTCTCCCTGCGTCGGGGGGCCAACCCCGGCTTCCATGAGGCCATT GGGGACGTGCTGGCGCTCTCGGTCTCCACTCCTGAACATCTGCACAAAATCGGCCTGCTG GACCGTGTCACCAATGACACGGAAAGTGACATCAATTACTTGCTAAAAATGGCACTGGAA AAAATTGCCTTCCTGCCCTTTGGCTACTTGGTGGACCAGTGGCGCTGGGGGGTCTTTAGT GGGCGTACCCCCCCTTCCCGCTACAACTTCGACTGGTGGTATCTTCGAACCAAGTATCAG GGGATCTGTCCTCCTGTTACCCGAAACGAAACCCACTTTGATGCTGGAGCTAAGTTTCAT GTTCCAAATGTGACACCATACATCAGGTACTTTGTGAGTTTTGTCCTGCAGTTCCAGTTC CATGAAGCCCTGTGCAAGGAGGCAGGCTATGAGGGCCCACTGCACCAGTGTGACATCTAC CGGTCCACCAAGGCAGGGGCCAAGCTCCGGAAGGTGCTGCAGGCTGGCTCCTCCAGGCCC TGGCAGGAGGTGCTGAAGGACATGGTCGGCTTAGATGCCCTGGATGCCCAGCCGCTGCTC AAGTACTTCCAGCCAGTCACCCAGTGGCTGCAGGAGCAGAACCAGCAGAACGGCGAGGTC CTGGGCTGGCCCGAGTACCAGTGGCACCCGCCGTTGCCTGACAACTACCCGGAGGGCATA GACCTGGTGACTGATGAGGCTGAGGCCAGCAAGTTTGTGGAGGAATATGACCGGACATCC CAGGTGGTGTGGAACGAGTATGCCGAGGCCAACTGGAACTACAACACCAACATCACCACA GAGACCAGCAAGATTCTGCTGCAGAAGAACATGCAAATAGCCAACCACACCCTGAAGTAC GGCACCCAGGCCAGGAAGTTTGATGTGAACCAGTTGCAGAACACCACTATCAAGCGGATC ATAAAGAAGGTTCAGGACCTAGAACGGGCAGCGCTGCCTGCCCAGGAGCTGGAGGAGTAC AACAAGATCCTGTTGGATATGGAAACCACCTACAGCGTGGCCACTGTGTGCCACCCGAAT GGCAGCTGCCTGCAGCTCGAGCCAGATCTGACGAATGTGATGGCCACATCCCGGAAATAT GAAGACCTGTTATGGGCATGGGAGGGCTGGCGAGACAAGGCGGGGAGAGCCATCCTCCAG TTTTACCCGAAATACGTGGAACTCATCAACCAGGCTGCCCGGCTCAATGGCTATGTAGAT GCAGGGGACTCGTGGAGGTCTATGTACGAGACACCATCCCTGGAGCAAGACCTGGAGCGG CTCTTCCAGGAGCTGCAGCCACTCTACCTCAACCTGCATGCCTACGTGCGCCGGGCCCTG CACCGTCACTACGGGGCCCAGCACATCAACCTGGAGGGGCCCATTCCTGCTCACCTGCTG GGGAACATGTGGGCGCAGACCTGGTCCAACATCTATGACTTGGTGGTGCCCTTCCCTTCA GCCCCCTCGATGGACACCACAGAGGCTATGCTAAAGCAGGGCTGGACGCCCAGGAGGATG TTTAAGGAGGCTGATGATTTCTTCACCTCCCTGGGGCTGCTGCCCGTGCCTCCTGAGTTC TGGAACAAGTCGATGCTGGAGAAGCCAACCGACGGGCGGGAGGTGGTCTGCCACGCCTCG GCCTGGGACTTCTACAACGGCAAGGACTTCCGGATCAAGCAGTGCACCACCGTGAACTTG GAGGACCTGGTGGTGGCCCACCACGAAATGGGCCACATCCAGTATTTCATGCAGTACAAA GACTTACCTGTGGCCTTGAGGGAGGGTGCCAACCCCGGCTTCCATGAGGCCATTGGGGAC GTGCTAGCCCTCTCAGTGTCTACGCCCAAGCACCTGCACAGTCTCAACCTGCTGAGCAGT GAGGGTGGCAGCGACGAGCATGACATCAACTTTCTGATGAAGATGGCCCTTGACAAGATC GCCTTTATCCCCTTCAGCTACCTCGTCGATCAGTGGCGCTGGAGGGTATTTGATGGAAGC ATCACCAAGGAGAACTATAACCAGGAGTGGTGGAGCCTCAGGCTGAAGTACCAGGGCCTC TGCCCCCCAGTGCCCAGGACTCAAGGTGACTTTGACCCAGGGGCCAAGTTCCACATTCCT TCTAGCGTGCCTTACATCAGGTACTTTGTCAGCTTCATCATCCAGTTCCAGTTCCACGAG GCACTGTGCCAGGCAGCTGGCCACACGGGCCCCCTGCACAAGTGTGACATCTACCAGTCC AAGGAGGCCGGGCAGCGCCTGGCGACCGCCATGAAGCTGGGCTTCAGTAGGCCGTGGCCG GAAGCCATGCAGCTGATCACGGGCCAGCCCAACATGAGCGCCTCGGCCATGTTGAGCTAC TTCAAGCCGCTGCTGGACTGGCTCCGCACGGAGAACGAGCTGCATGGGGAGAAGCTGGGC TGGCCGCAGTACAACTGGACGCCGAACTCCGCTCGCTCAGAAGGGCCCCTCCCAGACAGC GGCCGCGTCAGCTTCCTGGGCCTGGACCTGGATGCGCAGCAGGCCCGCGTGGGCCAGTGG CTGCTGCTCTTCCTGGGCATCGCCCTGCTGGTAGCCACCCTGGGCCTCAGCCAGCGGCTC TTCAGCATCCGCCACCGCAGCCTCCACCGGCACTCCCACGGGCCCCAGTTCGGCTCCGAG GTGGAGCTGAGACACTCCTGA PF01401 Peptidase_M2 component cell component membrane function metallopeptidase activity function ion binding function peptidyl-dipeptidase A activity function cation binding function transition metal ion binding function zinc ion binding function binding function catalytic activity function peptidase activity function hydrolase activity process macromolecule metabolism process physiological process process protein metabolism process cellular protein metabolism process metabolism process proteolysis BE0002693 FEZ-1 protein Fluoribacter gormanii # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown FEZ-1 protein Involved in hydrolase activity blaFEZ-1 None 8.68 31466.0 Fluoribacter gormanii GenBank Gene Database Y17896 UniProtKB Q9K578 UniProt Accession Q9K578_9GAMM >FEZ-1 protein MKKVLSLTALMMVLNHSSFAYPMPNPFPPFRIAGNLYYVGTDDLASYLIVTPRGNILINS DLEANVPMIKASIKKLGFKFSDTKILLISHAHFDHAAGSELIKQQTKAKYMVMDEDVSVI LSGGKSDFHYANDSSTYFTQSTVDKVLHDGERVELGGTVLTAHLTPGHTRGCTTWTMKLK DHGKQYQAVIIGSIGVNPGYKLVDNITYPKIAEDYKHSIKVLESMRCDIFLGSHAGMFDL KNKYVLLQKGQNNPFVDPTGCKNYIEQKANDFYTELKKQETA >849 bp ATGAAAAAAGTATTAAGTTTAACCGCATTGATGATGGTATTGAACCATTCAAGCTTCGCA TATCCAATGCCAAATCCTTTTCCCCCATTCCGTATTGCTGGAAACTTGTACTATGTAGGC ACTGATGATCTCGCAAGCTACCTGATTGTCACACCGAGAGGGAACATTTTGATCAATAGT GATCTTGAGGCTAATGTTCCCATGATTAAAGCAAGTATAAAAAAACTAGGTTTTAAATTC AGTGATACTAAAATTTTGCTGATTAGCCATGCTCATTTTGATCATGCGGCCGGTAGCGAA TTAATTAAGCAACAAACAAAAGCAAAATATATGGTTATGGACGAGGATGTTTCGGTGATC CTGTCTGGCGGTAAATCTGATTTTCATTATGCTAATGATTCCAGTACTTATTTTACTCAG AGTACTGTGGATAAGGTTCTTCACGACGGAGAACGGGTGGAATTAGGAGGGACCGTATTA ACTGCTCATTTGACTCCTGGACACACTAGAGGCTGTACCACCTGGACAATGAAACTAAAA GATCACGGCAAGCAATATCAGGCCGTAATTATAGGAAGTATTGGCGTAAATCCTGGGTAT AAATTGGTTGATAATATAACTTATCCAAAAATTGCCGAAGATTATAAGCACTCCATAAAG GTACTTGAGTCAATGCGTTGCGATATTTTTCTAGGATCGCATGCCGGAATGTTTGATCTG AAGAATAAATATGTACTATTACAAAAAGGTCAAAACAATCCCTTTGTTGATCCCACAGGC TGTAAAAATTATATTGAACAAAAGGCAAACGATTTTTACACAGAACTTAAGAAGCAAGAA ACTGCCTAA PF00753 Lactamase_B BE0002694 Carbapenem-hydrolyzing beta-lactamase BlaB-1 Chryseobacterium meningosepticum # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Carbapenem-hydrolyzing beta-lactamase BlaB-1 Involved in zinc ion binding Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate blaB1 Cytoplasmic None 9.36 28144.0 Chryseobacterium meningosepticum GenBank Gene Database X96858 UniProtKB O08498 UniProt Accession BLAB1_FLAME Carbapenem-hydrolyzing beta-lactamase blaB-1 precursor CHbetaL-1 Class B carbapenemase blaB-1 EC 3.5.2.6 >Carbapenem-hydrolyzing beta-lactamase blaB-1 MLKKIKISLILALGLTSLQAFGQENPDVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVT DKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYST KMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGC IIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINE YQQKQKASN >750 bp ATGTTGAAAAAAATAAAAATAAGCTTGATTCTTGCTCTTGGGCTTACCAGTTTGCAGGCA TTTGGACAGGAGAATCCTGATGTCAAAATTGAAAAGCTAAAAGATAATCTGTATGTATAC ACAACCTACAATACATTTAACGGGACTAAATATGCCGCAAATGCAGTATATCTGGTAACT GATAAGGGTGTTGTGGTTATAGACTGTCCGTGGGGAGAAGACAAATTTAAAAGCTTTACG GACGAGATTTATAAAAAACACGGAAAGAAAGTTATTATGAATATTGCAACACATTCTCAT GATGATCGTGCCGGAGGTCTTGAATATTTTGGTAAAATAGGTGCAAAAACTTATTCTACT AAAATGACAGATTCTATTTTAGCAAAAGAGAATAAGCCAAGAGCACAATATACTTTTGAC AATAATAAATCTTTCAAAGTAGGAAAATCCGAGTTTCAGGTTTACTATCCCGGAAAAGGG CACACAGCAGATAATGTGGTGGTATGGTTTCCAAAAGAAAAAGTATTGGTTGGAGGTTGT ATTATAAAAAGTGCTGATTCAAAGGACCTGGGGTATATTGGAGAAGCATATGTAAACGAC TGGACGCAGTCTGTACACAATATTCAACAAAAGTTTTCCGGTGCTCAGTACGTTGTTGCA GGGCATGATGATTGGAAAGATCAAAGATCAATACAACATACACTAGACTTAATCAATGAA TATCAACAAAAACAAAAGGCTTCAAATTAA PF00753 Lactamase_B function catalytic activity function hydrolase activity function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds function ion binding function cation binding function transition metal ion binding function zinc ion binding function binding function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides function beta-lactamase activity process drug metabolism process metabolism process antibiotic metabolism process cellular metabolism process antibiotic catabolism process physiological process BE0003355 Metallo-beta-lactamase L1 Pseudomonas maltophilia # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Metallo-beta-lactamase L1 Involved in zinc ion binding Has a high activity against imipenem Periplasm (Potential) None 6.92 30801.0 Pseudomonas maltophilia GenBank Gene Database X75074 UniProtKB P52700 UniProt Accession BLA1_STEMA Beta-lactamase type II EC 3.5.2.6 Metallo-beta-lactamase L1 precursor Penicillinase >Metallo-beta-lactamase L1 MRSTLLAFALAVALPAAHTSAAEVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLT ALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRR TGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAG HTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCD VLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAGAR >873 bp ATGCGTTCTACCCTGCTCGCCTTCGCCCTGGCCGTCGCTCTTCCGGCCGCCCACACCAGC GCCGCCGAAGTACCACTGCCGCAGCTGCGGGCCTACACCGTGGACGCCTCGTGGCTGCAG CCGATGGCACCGCTGCAGATCGCCGACCACACCTGGCAGATCGGCACCGAGGACCTGACC GCGCTGCTTGTGCAGACCCCCGACGGCGCGGTGCTGCTCGACGGCGGCATGCCGCAGATG GCCAGCCACCTGCTGGACAACATGAAGGCGCGTGGCGTGACGCCTCGGGATCTGCGGCTG ATCCTGCTCAGCCACGCACACGCCGACCATGCCGGACCGGTGGCGGAGCTGAAGCGCCGT ACGGGCGCCAAAGTGGCGGCCAACGCCGAATCGGCGGTGCTGCTGGCGCGTGGCGGCAGC GATGACCTGCACTTCGGCGATGGCATCACCTACCCGCCTGCCAATGCAGACCGCATCGTC ATGGATGGTGAAGTGATCACGGTGGGCGGCATCGTGTTCACCGCGCACTTCATGGCGGGG CACACCCCGGGCAGCACCGCGTGGACCTGGACCGATACCCGCAATGGCAAGCCGGTGCGC ATCGCCTACGCCGACAGCCTGAGTGCACCGGGCTACCAGCTGCAGGGAAACCCCCGTTAT CCGCACCTGATCGAGGATTACAGGCGCAGCTTCGCGACGGTGCGGGCGCTGCCTTGCGAC GTGTTGCTGACACCGCATCCGGGTGCCAGCAACTGGGACTACGCCGCGGGTGCCAGGGCC GGTGCCAAGGCACTGACCTGCAAGGCCTACGCGGATGCGGCAGAACAGAAATTCGACGGG CAGCTGGCCAAGGAAACGGCCGGGGCCCGCTGA PF00753 Lactamase_B function hydrolase activity function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds function ion binding function cation binding function transition metal ion binding function zinc ion binding function binding function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides function beta-lactamase activity function catalytic activity process physiological process process drug metabolism process metabolism process antibiotic metabolism process cellular metabolism process antibiotic catabolism BE0004195 Beta-lactamase Aeromonas hydrophila # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Beta-lactamase Involved in beta-lactamase activity Can hydrolyze carbapenem compounds cphA Periplasm (Probable) None 8.9 28016.2 Aeromonas hydrophila GeneCards cphA GenBank Gene Database X57102 GenBank Protein Database 38824 UniProtKB P26918 UniProt Accession BLAB_AERHY >Beta-lactamase MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKG VTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQT RDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIF VYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPEL IDHYEALIKAAPQS >765 bp ATGATGAAAGGTTGGATGAAGTGTGGATTGGCCGGCGCCGTGGTGCTGATGGCGAGTTTC TGGGGTGGCAGCGTGCGGGCGGCGGGGATGTCGCTGACGCAGGTGAGCGGCCCTGTGTAT GTGGTAGAGGACAACTACTACGTGCAGGAAAATTCCATGGTCTATTTCGGGGCCAAGGGC GTGACTGTGGTGGGGGCGACCTGGACGCCGGACACCGCCCGCGAGCTGCACAAGCTGATC AAACGGGTCAGCCGCAAGCCGGTGCTGGAGGTGATCAACACCAACTACCACACCGACCGG GCTGGCGGTAACGCCTACTGGAAGTCCATCGGTGCCAAGGTGGTGTCGACCCGCCAGACC CGGGATCTGATGAAGAGCGACTGGGCCGAGATTGTTGCCTTTACCCGCAAGGGGCTGCCG GAGTACCCGGATCTGCCGCTGGTGCTGCCCAACGTGGTGCACGATGGCGACTTCACGCTG CAAGAGGGCAAGGTGCGCGCCTTCTACGCGGGCCCGGCCCATACGCCGGACGGCATCTTT GTCTACTTCCCCGACGAGCAGGTGCTCTATGGCAACTGCATTCTCAAGGAGAAGCTGGGC AACCTGAGCTTTGCCGATGTGAAGGCCTATCCACAGACGCTTGAGCGGCTGAAAGCGATG AAGCTGCCGATCAAGACGGTGATCGGCGGTCACGACTCACCGCTGCACGGCCCCGAGCTG ATTGATCACTACGAAGCGCTGATCAAGGCCGCACCCCAGTCATAA PF00753 Lactamase_B function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds function ion binding function cation binding function transition metal ion binding function zinc ion binding function binding function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides function beta-lactamase activity function catalytic activity function hydrolase activity process physiological process process drug metabolism process metabolism process antibiotic metabolism process cellular metabolism process antibiotic catabolism BE0004196 Organic hydroperoxide resistance protein, putative Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Organic hydroperoxide resistance protein, putative Posttranslational modification, protein turnover, chaperones VC_A1006 None 6.78 15056.9 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GenBank Gene Database AE003853 GenBank Protein Database 9657379 UniProtKB Q9KKU4 UniProt Accession Q9KKU4_VIBCH >Organic hydroperoxide resistance protein, putative MRNKNMSTIYQTSATASAGRNGVVSTEDKLLELNLSYPKEMGGSGTATNPEQLFAVGYAA CFSNAILHVAREAKVALKEAPVTATVGIGPNGQGGFALSVALAAHIALEDEQARQLVTVA HQVCPYSNAVRGNIDVQVSVNGLAL >1977 bp ATGAGCTCAGAAGAAAAACGATTGATCAAATTGCCAAGAACTCACAAAGATGGTCATCTT TTTGAAGTCTCTGAAGCCGCGATTGACTGGATTGAACAGTATCAACACTTTAAAGGTGTC ACGAAAAGCATTGTTGAACTTTTGAATCTGATCTCACTGCGTGGATTACGCAGTAGAGAT GGCTTAGTTTCAACCACAGAACTGATTGATGCAACCGATGGGCAGCTGACGCGTGCAGCC ATCCAGCAGCGCTTGAGAGCAGCGGTAGCTGTTGGATTGTTCAAACAAATCCCAGTGCGT TTTGAAGAGGGGCTGGCTGGCAAAACCATGCTCCATCGTTTCATTAACCCCAACCAATTG ATCTCGGTACTCGGCTCAACCAGCTTAGTCACTGAATCGGTTAAGCAAAATGAAAAGCAA AAGCGCTCAAAAGCATTAGCGCAGACGCAAGTCAATCAACGTTTACTGCATGAGCATGGT TTAAATACACCGCCAGCCATGAAAGATGAGGCTGATCAGTTTGTGGTCTCACCGACTAAC TGGGCAGGGATCATTGATCAAGCGTTAGCGCCACCCAGAACCCGCAAGAGCTACCAAAAG TCTATGGTTTCGATATCGGGTACTCGTGCTGTGATTGAAACACGATCGTCTAAAAACATC ATGACGGTCGACGATCTGATGACTTTGTTTGCCTTATTCACTTTAACAGTGCAATACCAT GATCATCACCAAGATGATTACCATTTCAATGCTAAACAAGCACCAAACAAAACGCCGCTG TATATCACCGACATTCTCTCTTTACGTGGCAAAAAAGACAGCGGCCCGGCACGTGACTCG ATCCGTGACAGTATTGATCGTATTGAATTTACCGATTTTCAGTTGCATGAACTGACGGGT CGTTGGCTCAGTGAGAATATGCCAGAAGGCTTTAAAAGCGATCGTTTTCGCTTTTTAGCG CGCACCATCACCGCTTCCGAAGAGGCACCTGTGGAAGGCAGTGATGGCGAGATCCGCATC AAACCCAATCTGTACATTTTGGTGTGGGAGCCTTCGTTTTTTGAAGAGCTATTGACGCGA GATTATTTCTTCCTATTTCCACCGGAGATCTTGAAACAACATACCTTGGTATTTCAGCTC TACTCCTATTTCCGTAGCCGAATGTCTCGTCGTCATACCGATGTAATGATGCTGAGTGAA CTCAACCAAAAATTGGCCAGAAACATCGAATGGCGACGGTTTTCTATGGATCTGATCCGC GAACTTCGTCGTCTCTCCGAAGGGAAGGGGAGTGAAGATCTGTTTGTGGTCAATCTCTGG GGTTATCACTTGACTGTGAAAAGCATTGAAGAGAAAGGCAAAGTGGTGGATTACCAAGTC GATATCAAATGTGATGTGGAAGAGGTACTGCGCTATTCACGCGCCAAAACCACCAACGCG GGTAAACGCAATATGGCTCCAACCTTGCCTAACCCTTTACGTAACGAGCTGGTTTCCAAG CAGAAACTGGCTGAGTTATCGAGCATCATCGATGGTGAATTTGAACCAATCCAGCGCAAA GCCCCTTCGCCGAGAGGCCGCTTAGGTCGGCGCGTGAAGCTACGTAAACATCTTGTCGAA ATCAATGCTGATGAAATCACCATTACTCTATCGCGTTATACCTCTCCAGAAGCGCTAGAA CGCAGTATAACGGCTTTAGCGGCTATGACTGGACACGCCCCTTCATCAATCAAAGAAGAG TGTGTAGAGCTCATAGACAAGCTAGATTGGCTGCGTGTTGAAAACGATGTGATCCAATAC CCGACATTGAGCAAGCTGCTTGAGCTCTACAACAGCCAAAATGAGAGTAAACATCTGTCG ATCGAAAAATTGATCGCAGGTTTAGCGGTACGCCGTAAAGTCTGTAAATTGGTTCAAGAT GGGCACATTGACGAAACGGTGTATCGAGCCTTAGATGAGATGGCCGCTGGAGCCTAA PF02566 OsmC process response to stimulus process response to stress "

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

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