Resource Guanine

Predicate	Value (sorted: none)
owl:sameAs	?:S-Adenosylmethionine
owl:sameAs	?:Calcium
owl:sameAs	?:EXPT01672
owl:sameAs	?:Tetrahydrofolic acid
owl:sameAs	?:L-Glutamic Acid
owl:sameAs	?:Cyclic Adenosine Monophosphate
owl:sameAs	?:L-Aspartic Acid
owl:sameAs	?:Guanine
owl:sameAs	?:Inosine
owl:sameAs	?:Azathioprine
ns1:description	" 73-40-5 experimental Takeo Suzuki, Toshihide Nakanishi, "(2'-Amino-2'-deoxypentofuranosyl) guanine and process for producing same." U.S. Patent US3987030, issued April, 1966. This compound belongs to the hypoxanthines. These are compounds containing the purine derivative 1H-purin-6(9H)-one. Hypoxanthines Organic Compounds Heterocyclic Compounds Imidazopyrimidines Purines and Purine Derivatives Pyrimidones Primary Aromatic Amines Imidazoles Polyamines pyrimidone primary aromatic amine pyrimidine imidazole azole polyamine primary amine amine organonitrogen compound logP -0.97 ALOGPS logS -1.8 ALOGPS Water Solubility 2.53e+00 g/l ALOGPS logP -1.2 ChemAxon IUPAC Name 2-aminopurin-6-one ChemAxon Traditional IUPAC Name guanine ChemAxon Molecular Weight 150.1182 ChemAxon Monoisotopic Weight 150.041584775 ChemAxon SMILES NC1=Nc2ncnc2C(=O)N1 ChemAxon Molecular Formula C5H4N5O ChemAxon InChI InChI=1S/C5H4N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H3,6,8,9,10,11) ChemAxon InChIKey InChIKey=IOJBSLDWMHFRAL-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 97.55 ChemAxon Refractivity 37.24 ChemAxon Polarizability 12.97 ChemAxon Rotatable Bond Count 0 ChemAxon H Bond Acceptor Count 5 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 6.91 ChemAxon pKa (strongest basic) -2.9 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Water Solubility 2080 mg/L (at 37 Â°C) YALKOWSKY,SH & DANNENFELSER,RM (1992) Melting Point 360 dec Â°C PhysProp logP -0.91 HANSCH,C ET AL. (1995) ChEBI 16235 PubChem Compound 764 PubChem Substance 46507057 KEGG Compound C00242 ChemSpider 440297 PDB GUN Wikipedia Guanine RxList http://www.rxlist.com/cgi/generic/thioguanine.htm SMP00427 Azathioprine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB00993 Azathioprine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00430 Thioguanine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00352 Tioguanine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00428 Mercaptopurine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00144 Adenosine Deaminase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00167 Adenylosuccinate Lyase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00168 AICA-Ribosiduria DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00203 Molybdenium Cofactor Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00537 Myoadenylate deaminase deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00210 Purine Nucleoside Phosphorylase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00536 Mitochondrial DNA depletion syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00365 Gout or Kelley-Seegmiller Syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00512 Xanthinuria type I DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00513 Xanthinuria type II DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00364 Lesch-Nyhan Syndrome (LNS) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00050 Purine Metabolism DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 BE0002734 Purine nucleoside phosphorylase Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) unknown Purine nucleoside phosphorylase Involved in transferase activity, transferring pentosyl groups TM_1596 None 7.22 29173.0 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GenBank Gene Database AE000512 UniProtKB Q9X1T2 UniProt Accession Q9X1T2_THEMA >Purine nucleoside phosphorylase MMKKIEEARTFISERTNLSPDILIILGSGFGPFIEKVEDPVIIDYKDIPHFPQPTVEGHS GKLVFGRISDKPVMIMAGRFHLYEGHDPATVAFPVYLAKYVGVKGVVVTNAAGAINPEFK PGEIILVRDIINFMFRNPLRGPNDEKIGPRFPDMSSVVDPEWARKIQERLSLKEGVYIGV LGPSYETPAEIRVFEKLGADLVGMSTVPEVIAAKHCGLKVVVFSCVTNMAAGITHGRLSH EEVVRTTKMAQGKIEKALTTAVEVF >798 bp TTAGAACACCTCCACTGCAGTGGTGAGAGCTTTTTCTATTTTACCCTGTGCCATTTTCGT TGTTCTCACCACTTCTTCGTGTGACAGTCTTCCGTGGGTGATACCGGCTGCCATGTTCGT CACACAGGAGAATACAACCACTTTGAGTCCACAATGTTTTGCAGCGATCACTTCTGGAAC GGTTGACATCCCAACAAGATCAGCTCCGAGCTTTTCAAAGACGCGTATCTCAGCTGGCGT CTCGTAACTTGGTCCAAGGACACCGATGTAAACCCCTTCCTTCAGGCTGAGTCTTTCCTG GATTTTCCTCGCCCATTCAGGATCAACAACCGAGGACATATCGGGAAACCTCGGACCTAT CTTTTCGTCGTTTGGACCTCTGAGAGGATTTCTGAACATGAAGTTTATTATGTCTCTCAC CAGAATGATTTCTCCAGGTTTGAACTCCGGGTTTATCGCACCGGCGGCGTTGGTTACAAC GACACCTTTCACTCCCACGTATTTTGCCAGATACACGGGAAAAGCCACCGTTGCTGGATC GTGACCCTCATAAAGGTGAAACCTTCCTGCCATGATCATAACTGGCTTATCGCTTATTCT TCCAAAAACGAGTTTCCCGCTGTGACCTTCCACGGTAGGTTGTGGGAAGTGAGGAATATC TTTATAATCTATAATAACAGGGTCTTCCACTTTTTCTATGAAAGGCCCAAAACCGGATCC CAGGATGATCAAAATGTCCGGTGAAAGGTTCGTTCTTTCACTTATAAACGTCCTTGCTTC TTCGATCTTTTTCATCAT PF00896 Mtap_PNP function transferase activity, transferring glycosyl groups function transferase activity, transferring pentosyl groups function purine-nucleoside phosphorylase activity function catalytic activity function transferase activity process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process metabolism process cellular metabolism BE0000250 Purine nucleoside phosphorylase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Purine nucleoside phosphorylase Nucleotide transport and metabolism PNP 14q13.1 None 6.95 32118.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:7892 GenAtlas NP GeneCards NP GenBank Gene Database X00737 GenBank Protein Database 35565 UniProtKB P00491 UniProt Accession PNPH_HUMAN EC 2.4.2.1 Inosine phosphorylase PNP >Purine nucleoside phosphorylase MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS >870 bp ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC AGCATTCCACTCCCTGACAAAGCCAGTTGA PF00896 Mtap_PNP function transferase activity, transferring pentosyl groups function purine-nucleoside phosphorylase activity function catalytic activity function transferase activity function transferase activity, transferring glycosyl groups process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process metabolism process cellular metabolism BE0001556 Purine nucleoside phosphorylase 2 Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Purine nucleoside phosphorylase 2 Nucleotide transport and metabolism The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except adenosine and deoxyadenosine xapA None 6.5 29835.0 Escherichia coli (strain K12) GenBank Gene Database X73828 GenBank Protein Database 929584 UniProtKB P45563 UniProt Accession XAPA_ECOLI EC 2.4.2.- >Xanthosine phosphorylase MSQVQFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVS TVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGS LRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEG FPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNM AEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA >873 bp TCATTTGGCCTCACCCGCGAGGCCGTTTCTTATTGTTTTTCTCAGGCAATTTTGCGCAGA AAGCCACAAATAAGGTTGATGAGGTTCTGCTTGTGAGCTCGCAGCCGCCAGCGTTTGCGC ATGTGACAATTTCACATCGCTTAAACCTTCCGCCATATTGGTAATCGCAGAGACCGCAAC GACTTTAAGGTCGCAATGGCGAGCTGAAATAACCTCAGGCACCACAGACATACCAACAAC ATCCCCACCAATAATTTGCATCATGCGAATTTCCGCCGCAGTCTCGAAATTCGGCCCCGG ATACGAGACGAACACGCCCTCCGTCAGAGGGAAACCCTCTTCTTTCGGCCACTTTTTGTA ACAGTGCGCGGTATTCCGCATCGTAGGCATTTGCCAGTGAGAAGAAGCGCTCTCCAAAAC GATCATCGTTAAGACCCACCATCGCGTACCGGGCATGGTGTTGATATGATCTTTCAATGC GACCAGGCTGCCTGCCCCCACTTCCGGACGCAGCGAGCCTGCCGCATTGGTGCAGAACAG TAGCTCGCAGCCCAGCAGCTTAAAGGTACGAATTGCGTCAGTCATAATGGTCATTCCACG ACCTTCGTAGAAATGTCCGCGACCTTTCATACATACCACCGGTACGCCCTGGAGATGGCC CAGCACTAACTCCCCCGCATGACCATGTACCGTACTTACCGGGAAGCCCGGCAGCTTTTC GTAGGAAATTGCGACAGCGTTCTCAATCTGATCGGCCAGCGCGCCGAGCCCGGAACCTAA AATAAAGGCCACTCGTGGCGTGAAATCAGGTTTATAAGTCTTGATAATATCTATGCAAAA CAGCGGGTTATGAGAAAATTGAACCTGAGACAT PF00896 Mtap_PNP function transferase activity function transferase activity, transferring glycosyl groups function transferase activity, transferring pentosyl groups function purine-nucleoside phosphorylase activity function catalytic activity process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process BE0002009 Xanthine phosphoribosyltransferase Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Xanthine phosphoribosyltransferase Nucleotide transport and metabolism Acts on guanine, xanthine and to a lesser extent hypoxanthine gpt Cytoplasm None 5.63 16971.0 Escherichia coli (strain K12) GenBank Gene Database X00221 GenBank Protein Database 41607 UniProtKB P0A9M5 UniProt Accession XGPT_ECOLI EC 2.4.2.22 Xanthine-guanine phosphoribosyltransferase XGPRT >Xanthine phosphoribosyltransferase MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCI SSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRP LVDDYVVDIPQDTWIEQPWDMGVVFVPPISGR >459 bp ATGAGCGAAAAATACATCGTCACCTGGGACATGTTGCAGATCCATGCACGTAAACTCGCA AGCCGACTGATGCCTTCTGAACAATGGAAAGGCATTATTGCCGTAAGCCGTGGCGGTCTG GTACCGGGTGCGTTACTGGCGCGTGAACTGGGTATTCGTCATGTCGATACCGTTTGTATT TCCAGCTACGATCACGACAACCAGCGCGAGCTTAAAGTGCTGAAACGCGCAGAAGGCGAT GGCGAAGGCTTCATCGTTATTGATGACCTGGTGGATACCGGTGGTACTGCGGTTGCGATT CGTGAAATGTATCCAAAAGCGCACTTTGTCACCATCTTCGCAAAACCGGCTGGTCGTCCG CTGGTTGATGACTATGTTGTTGATATCCCGCAAGATACCTGGATTGAACAGCCGTGGGAT ATGGGCGTCGTATTCGTCCCGCCAATCTCCGGTCGCTAA PF00156 Pribosyltran function catalytic activity function transferase activity process nucleoside metabolism process physiological process process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism BE0001055 GTP cyclohydrolase 1 Human inhibitor # Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11752352 unknown GTP cyclohydrolase 1 Coenzyme transport and metabolism Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown GCH1 14q22.1-q22.2 Cytoplasmic None 8.82 27903.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:4193 GenAtlas GCH1 GeneCards GCH1 GenBank Gene Database Z29434 GenBank Protein Database 7242659 UniProtKB P30793 UniProt Accession GCH1_HUMAN EC 3.5.4.16 GTP-CH-I >GTP cyclohydrolase I MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRS EEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDA IFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQ VQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKT REEFLTLIRS >753 bp ATGGAGAAGGGCCCTGTGCGGGCACCGGCGGAGAAGCCGCGGGGCGCCAGGTGCAGCAAT GGGTTCCCCGAGCGGGATCCGCCGCGGCCCGGGCCCAGCAGGCCGGCGGAGAAGCCCCCG CGGCCCGAGGCCAAGAGCGCGCAGCCCGCGGACGGCTGGAAGGGCGAGCGGCCCCGCAGC GAGGAGGATAACGAGCTGAACCTCCCTAACCTGGCAGCCGCCTACTCGTCCATCCTGAGC TCGCTGGGCGAGAACCCCCAGCGGCAAGGGCTGCTCAAGACGCCCTGGAGGGCGGCCTCG GCCATGCAGTTCTTCACCAAGGGCTACCAGGAGACCATCTCAGATGTCCTAAACGATGCT ATATTTGATGAAGATCATGATGAGATGGTGATTGTGAAGGACATAGACATGTTTTCCATG TGTGAGCATCACTTGGTTCCATTTGTTGGAAAGGTCCATATTGGTTATCTTCCTAACAAG CAAGTCCTTGGCCTCAGCAAACTTGCGAGGATTGTAGAAATCTATAGTAGAAGACTACAA GTTCAGGAGCGCCTTACAAAACAAATTGCTGTAGCAATCACGGAAGCCTTGCGGCCTGCT GGAGTCGGGGTAGTGGTTGAAGCAACACACATGTGTATGGTAATGCGAGGTGTACAGAAA ATGAACAGCAAAACTGTGACCAGCACAATGTTGGGTGTGTTCCGGGAGGATCCAAAGACT CGGGAAGAGTTCCTGACTCTCATTAGGAGCTGA PF01227 GTP_cyclohydroI function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines function cyclohydrolase activity function GTP cyclohydrolase activity function GTP cyclohydrolase I activity function catalytic activity function hydrolase activity function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds process biosynthesis process physiological process process metabolism "
rdfs:label	"Guanine"
owl:sameAs	?:L-Glutamine
owl:sameAs	?:Glycine
owl:sameAs	?:Aicar
owl:sameAs	?:Hypoxanthine
owl:sameAs	?:Zinc
owl:sameAs	?:Xanthine
owl:sameAs	?:Fumarate
owl:sameAs	?:Mercaptopurine
owl:sameAs	?:Guanosine-5'-Monophosphate
owl:sameAs	?:Tioguanine
owl:sameAs	?:Adenosine
owl:sameAs	?:Potassium
owl:sameAs	?:7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione
rdf:type	ns1:drugs
owl:sameAs	?:Guanosine

" 73-40-5 experimental Takeo Suzuki, Toshihide Nakanishi, "(2'-Amino-2'-deoxypentofuranosyl) guanine and process for producing same." U.S. Patent US3987030, issued April, 1966. This compound belongs to the hypoxanthines. These are compounds containing the purine derivative 1H-purin-6(9H)-one. Hypoxanthines Organic Compounds Heterocyclic Compounds Imidazopyrimidines Purines and Purine Derivatives Pyrimidones Primary Aromatic Amines Imidazoles Polyamines pyrimidone primary aromatic amine pyrimidine imidazole azole polyamine primary amine amine organonitrogen compound logP -0.97 ALOGPS logS -1.8 ALOGPS Water Solubility 2.53e+00 g/l ALOGPS logP -1.2 ChemAxon IUPAC Name 2-aminopurin-6-one ChemAxon Traditional IUPAC Name guanine ChemAxon Molecular Weight 150.1182 ChemAxon Monoisotopic Weight 150.041584775 ChemAxon SMILES NC1=Nc2ncnc2C(=O)N1 ChemAxon Molecular Formula C5H4N5O ChemAxon InChI InChI=1S/C5H4N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H3,6,8,9,10,11) ChemAxon InChIKey InChIKey=IOJBSLDWMHFRAL-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 97.55 ChemAxon Refractivity 37.24 ChemAxon Polarizability 12.97 ChemAxon Rotatable Bond Count 0 ChemAxon H Bond Acceptor Count 5 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 6.91 ChemAxon pKa (strongest basic) -2.9 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Water Solubility 2080 mg/L (at 37 Â°C) YALKOWSKY,SH & DANNENFELSER,RM (1992) Melting Point 360 dec Â°C PhysProp logP -0.91 HANSCH,C ET AL. (1995) ChEBI 16235 PubChem Compound 764 PubChem Substance 46507057 KEGG Compound C00242 ChemSpider 440297 PDB GUN Wikipedia Guanine RxList http://www.rxlist.com/cgi/generic/thioguanine.htm SMP00427 Azathioprine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB00993 Azathioprine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00430 Thioguanine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00352 Tioguanine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00428 Mercaptopurine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00144 Adenosine Deaminase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00167 Adenylosuccinate Lyase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00168 AICA-Ribosiduria DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00203 Molybdenium Cofactor Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00537 Myoadenylate deaminase deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00210 Purine Nucleoside Phosphorylase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00536 Mitochondrial DNA depletion syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00365 Gout or Kelley-Seegmiller Syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00512 Xanthinuria type I DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00513 Xanthinuria type II DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00364 Lesch-Nyhan Syndrome (LNS) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00050 Purine Metabolism DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 BE0002734 Purine nucleoside phosphorylase Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) unknown Purine nucleoside phosphorylase Involved in transferase activity, transferring pentosyl groups TM_1596 None 7.22 29173.0 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GenBank Gene Database AE000512 UniProtKB Q9X1T2 UniProt Accession Q9X1T2_THEMA >Purine nucleoside phosphorylase MMKKIEEARTFISERTNLSPDILIILGSGFGPFIEKVEDPVIIDYKDIPHFPQPTVEGHS GKLVFGRISDKPVMIMAGRFHLYEGHDPATVAFPVYLAKYVGVKGVVVTNAAGAINPEFK PGEIILVRDIINFMFRNPLRGPNDEKIGPRFPDMSSVVDPEWARKIQERLSLKEGVYIGV LGPSYETPAEIRVFEKLGADLVGMSTVPEVIAAKHCGLKVVVFSCVTNMAAGITHGRLSH EEVVRTTKMAQGKIEKALTTAVEVF >798 bp TTAGAACACCTCCACTGCAGTGGTGAGAGCTTTTTCTATTTTACCCTGTGCCATTTTCGT TGTTCTCACCACTTCTTCGTGTGACAGTCTTCCGTGGGTGATACCGGCTGCCATGTTCGT CACACAGGAGAATACAACCACTTTGAGTCCACAATGTTTTGCAGCGATCACTTCTGGAAC GGTTGACATCCCAACAAGATCAGCTCCGAGCTTTTCAAAGACGCGTATCTCAGCTGGCGT CTCGTAACTTGGTCCAAGGACACCGATGTAAACCCCTTCCTTCAGGCTGAGTCTTTCCTG GATTTTCCTCGCCCATTCAGGATCAACAACCGAGGACATATCGGGAAACCTCGGACCTAT CTTTTCGTCGTTTGGACCTCTGAGAGGATTTCTGAACATGAAGTTTATTATGTCTCTCAC CAGAATGATTTCTCCAGGTTTGAACTCCGGGTTTATCGCACCGGCGGCGTTGGTTACAAC GACACCTTTCACTCCCACGTATTTTGCCAGATACACGGGAAAAGCCACCGTTGCTGGATC GTGACCCTCATAAAGGTGAAACCTTCCTGCCATGATCATAACTGGCTTATCGCTTATTCT TCCAAAAACGAGTTTCCCGCTGTGACCTTCCACGGTAGGTTGTGGGAAGTGAGGAATATC TTTATAATCTATAATAACAGGGTCTTCCACTTTTTCTATGAAAGGCCCAAAACCGGATCC CAGGATGATCAAAATGTCCGGTGAAAGGTTCGTTCTTTCACTTATAAACGTCCTTGCTTC TTCGATCTTTTTCATCAT PF00896 Mtap_PNP function transferase activity, transferring glycosyl groups function transferase activity, transferring pentosyl groups function purine-nucleoside phosphorylase activity function catalytic activity function transferase activity process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process metabolism process cellular metabolism BE0000250 Purine nucleoside phosphorylase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Purine nucleoside phosphorylase Nucleotide transport and metabolism PNP 14q13.1 None 6.95 32118.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:7892 GenAtlas NP GeneCards NP GenBank Gene Database X00737 GenBank Protein Database 35565 UniProtKB P00491 UniProt Accession PNPH_HUMAN EC 2.4.2.1 Inosine phosphorylase PNP >Purine nucleoside phosphorylase MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS >870 bp ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC AGCATTCCACTCCCTGACAAAGCCAGTTGA PF00896 Mtap_PNP function transferase activity, transferring pentosyl groups function purine-nucleoside phosphorylase activity function catalytic activity function transferase activity function transferase activity, transferring glycosyl groups process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process metabolism process cellular metabolism BE0001556 Purine nucleoside phosphorylase 2 Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Purine nucleoside phosphorylase 2 Nucleotide transport and metabolism The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except adenosine and deoxyadenosine xapA None 6.5 29835.0 Escherichia coli (strain K12) GenBank Gene Database X73828 GenBank Protein Database 929584 UniProtKB P45563 UniProt Accession XAPA_ECOLI EC 2.4.2.- >Xanthosine phosphorylase MSQVQFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVS TVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGS LRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEG FPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNM AEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA >873 bp TCATTTGGCCTCACCCGCGAGGCCGTTTCTTATTGTTTTTCTCAGGCAATTTTGCGCAGA AAGCCACAAATAAGGTTGATGAGGTTCTGCTTGTGAGCTCGCAGCCGCCAGCGTTTGCGC ATGTGACAATTTCACATCGCTTAAACCTTCCGCCATATTGGTAATCGCAGAGACCGCAAC GACTTTAAGGTCGCAATGGCGAGCTGAAATAACCTCAGGCACCACAGACATACCAACAAC ATCCCCACCAATAATTTGCATCATGCGAATTTCCGCCGCAGTCTCGAAATTCGGCCCCGG ATACGAGACGAACACGCCCTCCGTCAGAGGGAAACCCTCTTCTTTCGGCCACTTTTTGTA ACAGTGCGCGGTATTCCGCATCGTAGGCATTTGCCAGTGAGAAGAAGCGCTCTCCAAAAC GATCATCGTTAAGACCCACCATCGCGTACCGGGCATGGTGTTGATATGATCTTTCAATGC GACCAGGCTGCCTGCCCCCACTTCCGGACGCAGCGAGCCTGCCGCATTGGTGCAGAACAG TAGCTCGCAGCCCAGCAGCTTAAAGGTACGAATTGCGTCAGTCATAATGGTCATTCCACG ACCTTCGTAGAAATGTCCGCGACCTTTCATACATACCACCGGTACGCCCTGGAGATGGCC CAGCACTAACTCCCCCGCATGACCATGTACCGTACTTACCGGGAAGCCCGGCAGCTTTTC GTAGGAAATTGCGACAGCGTTCTCAATCTGATCGGCCAGCGCGCCGAGCCCGGAACCTAA AATAAAGGCCACTCGTGGCGTGAAATCAGGTTTATAAGTCTTGATAATATCTATGCAAAA CAGCGGGTTATGAGAAAATTGAACCTGAGACAT PF00896 Mtap_PNP function transferase activity function transferase activity, transferring glycosyl groups function transferase activity, transferring pentosyl groups function purine-nucleoside phosphorylase activity function catalytic activity process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process BE0002009 Xanthine phosphoribosyltransferase Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Xanthine phosphoribosyltransferase Nucleotide transport and metabolism Acts on guanine, xanthine and to a lesser extent hypoxanthine gpt Cytoplasm None 5.63 16971.0 Escherichia coli (strain K12) GenBank Gene Database X00221 GenBank Protein Database 41607 UniProtKB P0A9M5 UniProt Accession XGPT_ECOLI EC 2.4.2.22 Xanthine-guanine phosphoribosyltransferase XGPRT >Xanthine phosphoribosyltransferase MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCI SSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRP LVDDYVVDIPQDTWIEQPWDMGVVFVPPISGR >459 bp ATGAGCGAAAAATACATCGTCACCTGGGACATGTTGCAGATCCATGCACGTAAACTCGCA AGCCGACTGATGCCTTCTGAACAATGGAAAGGCATTATTGCCGTAAGCCGTGGCGGTCTG GTACCGGGTGCGTTACTGGCGCGTGAACTGGGTATTCGTCATGTCGATACCGTTTGTATT TCCAGCTACGATCACGACAACCAGCGCGAGCTTAAAGTGCTGAAACGCGCAGAAGGCGAT GGCGAAGGCTTCATCGTTATTGATGACCTGGTGGATACCGGTGGTACTGCGGTTGCGATT CGTGAAATGTATCCAAAAGCGCACTTTGTCACCATCTTCGCAAAACCGGCTGGTCGTCCG CTGGTTGATGACTATGTTGTTGATATCCCGCAAGATACCTGGATTGAACAGCCGTGGGAT ATGGGCGTCGTATTCGTCCCGCCAATCTCCGGTCGCTAA PF00156 Pribosyltran function catalytic activity function transferase activity process nucleoside metabolism process physiological process process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism BE0001055 GTP cyclohydrolase 1 Human inhibitor # Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11752352 unknown GTP cyclohydrolase 1 Coenzyme transport and metabolism Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown GCH1 14q22.1-q22.2 Cytoplasmic None 8.82 27903.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:4193 GenAtlas GCH1 GeneCards GCH1 GenBank Gene Database Z29434 GenBank Protein Database 7242659 UniProtKB P30793 UniProt Accession GCH1_HUMAN EC 3.5.4.16 GTP-CH-I >GTP cyclohydrolase I MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRS EEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDA IFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQ VQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKT REEFLTLIRS >753 bp ATGGAGAAGGGCCCTGTGCGGGCACCGGCGGAGAAGCCGCGGGGCGCCAGGTGCAGCAAT GGGTTCCCCGAGCGGGATCCGCCGCGGCCCGGGCCCAGCAGGCCGGCGGAGAAGCCCCCG CGGCCCGAGGCCAAGAGCGCGCAGCCCGCGGACGGCTGGAAGGGCGAGCGGCCCCGCAGC GAGGAGGATAACGAGCTGAACCTCCCTAACCTGGCAGCCGCCTACTCGTCCATCCTGAGC TCGCTGGGCGAGAACCCCCAGCGGCAAGGGCTGCTCAAGACGCCCTGGAGGGCGGCCTCG GCCATGCAGTTCTTCACCAAGGGCTACCAGGAGACCATCTCAGATGTCCTAAACGATGCT ATATTTGATGAAGATCATGATGAGATGGTGATTGTGAAGGACATAGACATGTTTTCCATG TGTGAGCATCACTTGGTTCCATTTGTTGGAAAGGTCCATATTGGTTATCTTCCTAACAAG CAAGTCCTTGGCCTCAGCAAACTTGCGAGGATTGTAGAAATCTATAGTAGAAGACTACAA GTTCAGGAGCGCCTTACAAAACAAATTGCTGTAGCAATCACGGAAGCCTTGCGGCCTGCT GGAGTCGGGGTAGTGGTTGAAGCAACACACATGTGTATGGTAATGCGAGGTGTACAGAAA ATGAACAGCAAAACTGTGACCAGCACAATGTTGGGTGTGTTCCGGGAGGATCCAAAGACT CGGGAAGAGTTCCTGACTCTCATTAGGAGCTGA PF01227 GTP_cyclohydroI function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines function cyclohydrolase activity function GTP cyclohydrolase activity function GTP cyclohydrolase I activity function catalytic activity function hydrolase activity function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds process biosynthesis process physiological process process metabolism "

owl:sameAs

?:L-Glutamine

?:Guanosine-5'-Monophosphate

owl:sameAs

?:Adenosine

owl:sameAs

?:7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione

owl:sameAs

?:Guanosine

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