Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03397"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"Uridine-Diphosphate-N-Acetylglucosamine"
|
| rdf:type | |
| ns1:description |
"
experimental
This compound belongs to the pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group.
Pyrimidine Nucleotide Sugars
Organic Compounds
Organooxygen Compounds
Carbohydrates and Carbohydrate Conjugates
Glycosyl Compounds
Pyrimidine Ribonucleoside Diphosphates
Mixed Pentose/Hexose Disaccharides
N-acyl-alpha-hexosamines
Disaccharide Phosphates
Organic Pyrophosphates
Pyrimidones
Organic Phosphoric Acids
Hydropyrimidines
Oxanes
Organophosphate Esters
Tetrahydrofurans
Oxolanes
Secondary Carboxylic Acid Amides
Secondary Alcohols
1,2-Diols
Primary Alcohols
Enolates
Polyamines
Carboxylic Acids
Ethers
mixed pentose/hexose disaccharide
n-acyl-alpha-hexosamine
disaccharide phosphate
glucosamine
disaccharide
amino sugar
organic pyrophosphate
pyrimidone
organic phosphate
phosphoric acid ester
oxane
hydropyrimidine
pyrimidine
tetrahydrofuran
oxolane
1,2-diol
secondary alcohol
secondary carboxylic acid amide
carboxamide group
primary alcohol
carboxylic acid
carboxylic acid derivative
ether
polyamine
enolate
alcohol
amine
organonitrogen compound
logP
-1.4
ALOGPS
logS
-1.7
ALOGPS
Water Solubility
1.14e+01 g/l
ALOGPS
logP
-5.3
ChemAxon
IUPAC Name
[({[(2S,3R,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2S,3S,4S,5R,6S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid
ChemAxon
Traditional IUPAC Name
{[(2S,3R,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy[(2S,3S,4S,5R,6S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphinic acid
ChemAxon
Molecular Weight
607.3537
ChemAxon
Monoisotopic Weight
607.081569477
ChemAxon
SMILES
CC(=O)N[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[P@](O)(=O)O[P@](O)(=O)OC[C@@H]1O[C@H]([C@H](O)[C@H]1O)N1C=CC(=O)NC1=O
ChemAxon
Molecular Formula
C17H27N3O17P2
ChemAxon
InChI
InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11-,12-,13-,14+,15+,16-/m0/s1
ChemAxon
InChIKey
InChIKey=LFTYTUAZOPRMMI-LSIJYXAZSA-N
ChemAxon
Polar Surface Area (PSA)
300.41
ChemAxon
Refractivity
117.56
ChemAxon
Polarizability
49.62
ChemAxon
Rotatable Bond Count
10
ChemAxon
H Bond Acceptor Count
14
ChemAxon
H Bond Donor Count
9
ChemAxon
pKa (strongest acidic)
1.74
ChemAxon
pKa (strongest basic)
-3.5
ChemAxon
Physiological Charge
-2
ChemAxon
Number of Rings
3
ChemAxon
Bioavailability
0
ChemAxon
MDDR-Like Rule
true
ChemAxon
PubChem Compound
46936661
PubChem Substance
46506870
PDB
UD1
BE0002025
Bifunctional protein GlmU
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Bifunctional protein GlmU
Cell wall/membrane/envelope biogenesis
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc
glmU
Cytoplasm
None
6.52
49191.0
Escherichia coli (strain K12)
GenBank Gene Database
X01631
UniProtKB
P0ACC7
UniProt Accession
GLMU_ECOLI
EC 2.3.1.157]
EC 2.7.7.23
Glucosamine-1-phosphate N-acetyltransferase
N-acetylglucosamine-1-phosphate uridyltransferase
>Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase
MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGD
LLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDA
KPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADM
KRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQ
SEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKN
SVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSK
AGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGAT
IAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
PF00132
Hexapep
PF01128
IspD
function
transferase activity
function
transferase activity, transferring phosphorus-containing groups
function
4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity
function
UDP-N-acetylglucosamine diphosphorylase activity
function
nucleotidyltransferase activity
function
catalytic activity
process
metabolism
process
carbohydrate biosynthesis
process
macromolecule metabolism
process
polysaccharide biosynthesis
process
lipopolysaccharide biosynthesis
process
macromolecule biosynthesis
process
primary metabolism
process
lipid metabolism
process
cellular lipid metabolism
process
physiological process
process
isoprenoid metabolism
process
isoprenoid biosynthesis
BE0001429
UDP-N-acetylhexosamine pyrophosphorylase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-N-acetylhexosamine pyrophosphorylase
Involved in nucleotidyltransferase activity
Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P
UAP1
1q23.3
Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the
None
6.29
58770.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12457
GenAtlas
UAP1
GeneCards
UAP1
GenBank Gene Database
S73498
GenBank Protein Database
7717462
UniProtKB
Q16222
UniProt Accession
UAP1_HUMAN
AGX
AGX-1
Antigen X
EC 2.7.7.-
EC 2.7.7.23
Sperm- associated antigen 2
UDP-N-acetylglucosamine pyrophosphorylase
>UDP-N-acetylhexosamine pyrophosphorylase
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSS
HQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAY
PKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTK
HKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDME
QRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ
VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPY
VDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTT
ARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQ
CEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
>1518 bp
ATGAACATTAATGACCTCAAACTCACGTTGTCCAAAGCTGGGCAAGAGCACCTACTACGT
TTCTGGAATGAGCTTGAAGAAGCCCAACAGGTAGAACTTTATGCAGAGCTCCAGGCCATG
AACTTTGAGGAGCTGAACTTCTTTTTCCAAAAGGCCATTGAAGGTTTTAACCAGTCTTCT
CACCAAAAGAATGTGGATGCACGAATGGAACCTGTGCCTCGAGAGGTATTAGGCAGTGCT
ACAAGGGATCAAGATCAGCTCCAGGCCTGGGAAAGTGAAGGACTTTTCCAGATTTCTCAG
AATAAAGTAGCAGTTCTTCTTCTAGCTGGTGGGCAGGGGACAAGACTCGGCGTTGCATAT
CCTAAGGGGATGTATGATGTTGGTTTGCCATCCCGTAAGACACTTTTTCAGATTCAAGCA
GAGCGTATCCTGAAGCTACAGCAGGTTGCTGAAAAATATTATGGCAACAAATGCATTATT
CCATGGTATATAATGACCAGTGGCAGAACAATGGAATCTACAAAGGAGTTCTTCACCAAG
CACAAGTACTTTGGTTTAAAAAAAGAGAATGTAATCTTTTTTCAGCAAGGAATGCTCCCC
GCCATGAGTTTTGATGGGAAAATTATTTTGGAAGAGAAGAACAAAGTTTCTATGGCTCCA
GATGGGAATGGTGGTCTTTATCGGGCACTTGCAGCCCAGAATATTGTGGAGGATATGGAG
CAAAGAGGCATTTGGAGCATTCATGTCTATTGTGTTGACAACATATTAGTAAAAGTGGCA
GACCCACGGTTCATTGGATTTTGCATTCAGAAAGGAGCAGACTGTGGAGCAAAGGTGGTA
GAGAAAACGAACCCTACAGAACCAGTTGGAGTGGTTTGCCGAGTGGATGGAGTTTACCAG
GTGGTAGAATATAGTGAGATTTCCCTGGCAACAGCTCAAAAACGAAGCTCAGACGGACGA
CTGCTGTTCAATGCGGGGAACATTGCCAACCATTTCTTCACTGTACCATTTCTGAGAGAT
GTTGTCAATGTTTATGAACCTCAGTTGCAGCACCATGTGGCTCAAAAGAAGATTCCTTAT
GTGGATACCCAAGGACAGTTAATTAAGCCAGACAAACCCAATGGAATAAAGATGGAAAAA
TTTGTCTTTGACATCTTCCAGTTTGCAAAGAAGTTTGTGGTATATGAAGTATTGCGAGAA
GATGAGTTTTCCCCACTAAAGAATGCTGATAGTCAGAATGGGAAAGACAACCCTACTACT
GCAAGGCATGCTTTGATGTCCCTTCATCATTGCTGGGTCCTCAATGCAGGGGGCCATTTC
ATAGATGAAAATAGCTCTCGCCTTCCAGCAATTCCCCGCTTGAAGGATGCCAATGATGTA
CCAATCCAATGTGAAATCTCTCCTCTTATCTCCTATGCTGGAGAAGGATTAGAAAGTTAT
GTGGCAGATAAAGAATTCCATGCACCTCTAATCATCGATGAGAATGGAGTTCATGAGCTG
GTGAAAAATGGTATTTGA
PF01704
UDPGP
function
transferase activity
function
transferase activity, transferring phosphorus-containing groups
function
nucleotidyltransferase activity
function
catalytic activity
process
metabolism
process
physiological process
BE0001252
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Shigella flexneri
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Cell wall/membrane/envelope biogenesis
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
murA
Cytoplasm (Probable)
None
6.07
44818.0
Shigella flexneri
GenBank Gene Database
AE005674
GenBank Protein Database
24053661
UniProtKB
P0A751
UniProt Accession
MURA_SHIFL
EC 2.5.1.7
Enoylpyruvate transferase
EPT
UDP-N-acetylglucosamine enolpyruvyl transferase
>UDP-N-acetylglucosamine 1-carboxyvinyltransferase
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
>1260 bp
TTACTCGCCTTTCACACGCTCAATATTTGCACCTAAAGCGCGCAGTTTGTCTTCAATGCG
TTCGTAGCCACGATCGATGTGATAAATACGATCAACCACCGTCGTCCCTTCCGCAATACA
GCCAGCCAGCACCAGGCTTGCTGATGCACGCAGATCGGTTGCCATAACCTGTGCACCAGA
AAGTTTTTCAACACCATGACAAATAACGGTATTGCTTTCGATTTCGGCGTGCGCGCCCAT
ACGGCTCAGCTCTGGCACATGCATAAAGCGGTTTTCAAAGACCGTTTCGGTGATGAACCC
GGTCCCTTCAGCCACCAGGTTCAACAGCGTGAACTGGGCCTGCATATCGGTCGGGAATGC
CGGATGCGGCGCGGTACGTACGTTAACAGCCTTCGGACGTTTGCCATGCATATCCAGGCT
AATCCAGTCTTCGCCGACTTCGATGTCCGCTCCAGCATCACGCAGTTTCGCCAGCACGGC
GTCCAGAGTATCTGGCTGCGCGTTACGGCAGATAATTTTGCCACGAGAGATCGCCGCCGC
CACCAGGAAAGTACCGGTTTCGATACGATCCGGCAGCACGCGATAGACACCGCCGCCTAA
ACGTTCCACACCTTCGATGACGATACGATCGGTGCCCTGACCGCTAATTTTCGCACCCAG
CGTAATCAGGAAGTTCGCGGTATCGACGATTTCCGGTTCACGCGCTGCGTTTTCAATAAT
CGTGGTGCCTTCCGCCAGGGTTGCAGCACACATGATGGTCACCGTTGCGCCAACGCTGAC
TTTATCCATCACGATATGTGCGCCTTTCAGACGACCATCGACGGAAGCTTTAACGTAACC
TTCTTCCAGTTTGATGGTCGCGCCTAATTGTTCGAGGCCAGAAATGTGTAGATCAACCGG
ACGCGCACCGATCGTACAACCGCCAGGTAGTGAAACTTGCCCCTGACCAAAGCGCGCTAC
CAGCGGCCCCAGCGCCCAGATAGAAGCACGCATGGTTTTAACCAGATCGTAAGGTGCGCA
GAATACATTAACGTCGCGGGCATCAATATGCACAGAACCATTACGTTCTACTTTCGCACC
CAGCTGGCTTAGCAGTTTCATTGATGTATCGACGTCTTTCAGTTTCGGGACGTTCTGGAT
CTCTACCGGTTCTTCCGCCAGTAGTGCGGCAAAAAGAATAGGCAGAGCAGCATTTTTAGC
GCCGGAAATTGTGACTTCGCCCTGGAGCTTCGTTGGCCCCTGAACACGAAATTTATCCAT
PF00275
EPSP_synthase
function
catalytic activity
function
transferase activity
process
amino sugar metabolism
process
UDP-N-acetylgalactosamine metabolism
process
UDP-N-acetylgalactosamine biosynthesis
process
physiological process
process
metabolism
process
nitrogen compound metabolism
process
amine metabolism
BE0001521
UDP-glucose 4-epimerase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-glucose 4-epimerase
Cell wall/membrane/envelope biogenesis
Catalyzes two distinct but analogous reactions:the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine
GALE
1p36-p35
None
6.71
38282.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4116
GenAtlas
GALE
GeneCards
GALE
GenBank Gene Database
L41668
GenBank Protein Database
1119217
UniProtKB
Q14376
UniProt Accession
GALE_HUMAN
EC 5.1.3.2
Galactowaldenase
UDP-galactose 4-epimerase
>UDP-glucose 4-epimerase
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK
AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA
VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD
YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
>1047 bp
ATGGCAGAGAAGGTGCTGGTAACAGGTGGGGCTGGCTACATTGGCAGCCACACGGTGCTG
GAGCTGCTGGAGGCTGGCTACTTGCCTGTGGTCATCGATAACTTCCATAATGCCTTCCGT
GGAGGGGGCTCCCTGCCTGAGAGCCTGCGGCGGGTCCAGGAGCTGACAGGCCGCTCTGTG
GAGTTTGAGGAGATGGACATTTTGGACCAGGGAGCCCTACAGCGTCTCTTCAAAAAGTAC
AGCTTTATGGCGGTCATCCACTTTGCGGGGCTCAAGGCCGTGGGCGAGTCGGTGCAGAAG
CCTCTGGATTATTACAGAGTTAACCTGACCGGGACCATCCAGCTTCTGGAGATCATGAAG
GCCCACGGGGTGAAGAACCTGGTGTTCAGCAGCTCAGCCACTGTGTACGGGAACCCCCAG
TACCTGCCCCTTGATGAGGCCCACCCCACGGGTGGTTGTACCAACCCTTACGGCAAGTCC
AAGTTCTTCATCGAGGAAATGATCCGGGACCTGTGCCAGGCAGACAAGACTTGGAACGTA
GTGCTGCTGCGCTATTTCAACCCCACAGGTGCCCATGCCTCTGGCTGCATTGGTGAGGAT
CCCCAGGGCATACCCAACAACCTCATGCCTTATGTCTCCCAGGTGGCGATCGGGCGACGG
GAGGCCCTGAATGTCTTTGGCAATGACTATGACACAGAGGATGGCACAGGTGTCCGGGAT
TACATCCATGTCGTGGATCTGGCCAAGGGCCACATTGCAGCCTTAAGGAAGCTGAAAGAA
CAGTGTGGCTGCCGGATCTACAACCTGGGCACGGGCACAGGCTATTCAGTGCTGCAGATG
GTCCAGGCTATGGAGAAGGCCTCTGGGAAGAAGATCCCGTACAAGGTGGTGGCACGGCGG
GAAGGTGATGTGGCAGCCTGTTACGCCAACCCCAGCCTGGCCCAAGAGGAGCTGGGGTGG
ACAGCAGCCTTAGGGCTGGACAGGATGTGTGAGGATCTCTGGCGCTGGCAGAAGCAGAAT
CCTTCAGGCTTTGGCACGCAAGCCTGA
PF01370
Epimerase
function
catalytic activity
function
NAD binding
function
racemase and epimerase activity
function
cofactor binding
function
racemase and epimerase activity, acting on carbohydrates and derivatives
function
coenzyme binding
function
UDP-glucose 4-epimerase activity
function
isomerase activity
function
binding
process
monosaccharide metabolism
process
hexose metabolism
process
metabolism
process
cellular metabolism
process
nucleotide-sugar metabolism
process
macromolecule metabolism
process
galactose metabolism
process
carbohydrate metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
alcohol metabolism
process
physiological process
BE0003075
Bifunctional protein GlmU
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
unknown
Bifunctional protein GlmU
Involved in UDP-N-acetylglucosamine diphosphorylase activity
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc (Probable)
glmU
Cytoplasm
None
5.43
49345.0
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
GenBank Gene Database
AE005672
UniProtKB
Q97R46
UniProt Accession
GLMU_STRPN
>Bifunctional protein glmU
MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGHKAELVE
EVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLITGESLKNLIDFHIN
HKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATDFEKQIKEINTGTYVFDNERL
FEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMR
RRINHKHMVNGVSFVNPEATYIDIDVEIASEVQIEANVTLKGQTKIGAETVLTNGTYVVD
STIGAGAVITNSMIEESSVADGVIVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGENTKA
GHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGNNVFVGSNSTIIAPVELGDNSLV
GAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHPKNQ
>1380 bp
ATGTCAAATTTTGCCATTATTTTAGCAGCGGGTAAAGGGACTCGCATGAAATCTGATTTG
CCAAAAGTTTTGCACAAGGTTGCGGGTATTTCTATGTTGGAACATGTTTTCCGTAGTGTG
GGAGCTATCCAACCTGAAAAGACAGTAACAGTTGTAGGACACAAGGCAGAATTGGTTGAG
GAGGTCTTGGCTGGACAGACAGAATTTGTGACTCAATCTGAACAGTTGGGAACTGGTCAT
GCAGTTATGATGACAGAGCCTATCTTAGAAGGTTTGTCAGGACACACCTTGGTCATTGCA
GGAGATACTCCTTTAATCACTGGTGAAAGCTTGAAAAACTTGATTGATTTCCATATCAAT
CATAAAAATGTGGCCACTATCTTGACTGCTGAAACGGATAATCCTTTTGGTTATGGACGA
ATTGTTCGTAATGACAATGCTGAGGTTCTTCGTATTGTTGAGCAGAAGGATGCTACAGAT
TTTGAAAAGCAAATCAAGGAAATCAACACTGGAACATACGTCTTTGACAACGAGCGTTTG
TTTGAGGCTTTGAAAAATATCAATACCAATAACGCTCAAGGCGAATACTATATTACAGAC
GTCATTGGTATTTTCCGTGAAACTGGTGAAAAAGTTGGCGCTTATACTTTGAAAGATTTT
GATGAAAGTCTTGGGGTAAATGACCGTGTGGCGCTTGCGACAGCTGAGTCAGTTATGCGT
CGTCGCATCAATCATAAACACATGGTCAACGGTGTTAGCTTTGTCAATCCAGAAGCAACT
TATATCGATATTGATGTTGAGATTGCTTCGGAAGTTCAAATCGAAGCCAATGTTACCTTG
AAAGGGCAAACGAAAATTGGTGCTGAGACTGTTTTGACAAACGGTACTTATGTAGTGGAC
AGCACTATCGGAGCAGGAGCGGTCATTACCAATTCTATGATTGAGGAAAGTAGTGTTGCA
GACGGTGTGATAGTCGGTCCTTATGCTCACATTCGTCCAAATTCAAGTCTGGGTGCCCAA
GTTCATATTGGTAACTTTGTTGAGGTGAAAGGATCTTCAATCGGTGAGAATACCAAGGCT
GGTCATTTGACTTATATCGGAAACTGTGAAGTGGGAAGCAACGTTAATTTCGGTGCTGGA
ACTATTACAGTCAACTATGACGGCAAAAACAAATACAAGACAGTCATTGGAAACAATGTC
TTTGTTGGTTCAAATTCAACCATTATTGCACCAGTAGAACTTGGTGACAATTCCCTCGTT
GGTGCTGGTTCAACTATTACTAAAGACGTGCCAGCAGATGCTATTGCTATTGGTCGCGGT
CGTCAGATCAATAAAGACGAATATGCAACACGTCTTCCTCATCATCCTAAGAACCAGTAG
PF00132
Hexapep
PF01128
IspD
function
transferase activity
function
transferase activity, transferring phosphorus-containing groups
function
4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity
function
UDP-N-acetylglucosamine diphosphorylase activity
function
nucleotidyltransferase activity
function
catalytic activity
process
isoprenoid biosynthesis
process
metabolism
process
carbohydrate biosynthesis
process
macromolecule metabolism
process
polysaccharide biosynthesis
process
lipopolysaccharide biosynthesis
process
macromolecule biosynthesis
process
primary metabolism
process
lipid metabolism
process
cellular lipid metabolism
process
physiological process
process
isoprenoid metabolism
BE0001901
UDP-glucose 4-epimerase
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-glucose 4-epimerase
Cell wall/membrane/envelope biogenesis
UDP-glucose = UDP-galactose
galE
None
6.32
37266.0
Escherichia coli (strain K12)
GenBank Gene Database
X06226
GenBank Protein Database
41523
UniProtKB
P09147
UniProt Accession
GALE_ECOLI
EC 5.1.3.2
Galactowaldenase
UDP-galactose 4-epimerase
>UDP-glucose 4-epimerase
MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR
NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI
FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP
VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA
DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW
ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD
>1017 bp
ATGAGAGTTCTGGTTACCGGTGGTAGCGGTTACATTGGAAGTCATACCTGTGTGCAATTA
CTGCAAAACGGTCATGATGTCATCATTCTTGATAACCTCTGTAACAGTAAGCGCAGCGTA
CTGCCTGTTATCGAGCGTTTAGGCGGCAAACATCCAACGTTTGTTGAAGGCGATATTCGT
AACGAAGCGTTGATGACCGAGATCCTGCACGATCACGCTATCGACACCGTGATCCACTTC
GCCGGGCTGAAAGCCGTGGGCGAATCGGTACAAAAACCGCTGGAATATTACGACAACAAT
GTCAACGGCACTCTGCGCCTGATTAGCGCCATGCGCGCCGCTAACGTCAAAAACTTTATT
TTTAGCTCCTCCGCCACCGTTTATGGCGATCAGCCCAAAATTCCATACGTTGAAAGCTTC
CCGACCGGCACACCGCAAAGCCCTTACGGCAAAAGCAAGCTGATGGTGGAACAGATCCTC
ACCGATCTGCAAAAAGCCCAGCCGGACTGGAGCATTGCCCTGCTGCGCTACTTCAACCCG
GTTGGCGCGCATCCGTCGGGCGATATGGGCGAAGATCCGCAAGGCATTCCGAATAACCTG
ATGCCATACATCGCCCAGGTTGCTGTAGGCCGTCGCGACTCGCTGGCGATTTTTGGTAAC
GATTATCCGACCGAAGATGGTACTGGCGTACGCGATTACATCCACGTAATGGATCTGGCG
GACGGTCACGTCGTGGCGATGGAAAAACTGGCGAACAAGCCAGGCGTACACATCTACAAC
CTCGGCGCTGGCGTAGGCAACAGCGTGCTGGACGTGGTTAATGCCTTCAGCAAAGCCTGC
GGCAAACCGGTTAATTATCATTTTGCACCGCGTCGCGAGGGCGACCTTCCGGCCTACTGG
GCGGACGCCAGCAAAGCCGACCGTGAACTGAACTGGCGCGTAACGCGCACACTCGATGAA
ATGGCGCAGGACACCTGGCACTGGCAGTCACGCCATCCACAGGGATATCCCGATTAA
PF01370
Epimerase
function
coenzyme binding
function
UDP-glucose 4-epimerase activity
function
isomerase activity
function
binding
function
NAD binding
function
catalytic activity
function
racemase and epimerase activity
function
racemase and epimerase activity, acting on carbohydrates and derivatives
function
cofactor binding
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
alcohol metabolism
process
monosaccharide metabolism
process
hexose metabolism
process
physiological process
process
nucleotide-sugar metabolism
process
metabolism
process
cellular metabolism
process
galactose metabolism
BE0004629
Exostosin-like 2
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Exostosin-like 2
EXTL2
Human
UniProtKB
Q9UBQ6
UniProt Accession
EXTL2_HUMAN
BE0004519
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
MGAT1
Human
UniProtKB
P26572
UniProt Accession
MGAT1_HUMAN
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All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt
The resource does not appear as an object