Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03408"

Predicate	Value (sorted: default)
rdfs:label	"Gamma-Glutamylcysteine"
rdf:type	ns1:drugs
ns1:description	" 686-58-8 experimental Hiroaki Nishiuchi, "Method for producing gamma-glutamylcysteine." U.S. Patent US20030124684, issued July 03, 2003. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at his terminal nitrogen atom. N-acyl-alpha Amino Acids Organic Compounds Organic Acids and Derivatives Carboxylic Acids and Derivatives Amino Acids, Peptides, and Analogues Amino Fatty Acids Dicarboxylic Acids and Derivatives Polyols Secondary Carboxylic Acid Amides Enolates Alkylthiols Polyamines Carboxylic Acids Monoalkylamines dicarboxylic acid derivative polyol secondary carboxylic acid amide carboxamide group alkylthiol polyamine carboxylic acid enolate amine primary aliphatic amine primary amine organonitrogen compound logP -2.5 ALOGPS logS -2 ALOGPS Water Solubility 2.62e+00 g/l ALOGPS logP -3.8 ChemAxon IUPAC Name (2S)-2-amino-4-{[(1S)-1-carboxy-2-sulfanylethyl]carbamoyl}butanoic acid ChemAxon Traditional IUPAC Name gamma-glutamylcysteine ChemAxon Molecular Weight 250.272 ChemAxon Monoisotopic Weight 250.062342258 ChemAxon SMILES N[C@@H](CCC(=O)N[C@H](CS)C(O)=O)C(O)=O ChemAxon Molecular Formula C8H14N2O5S ChemAxon InChI InChI=1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m0/s1 ChemAxon InChIKey InChIKey=RITKHVBHSGLULN-CRCLSJGQSA-N ChemAxon Polar Surface Area (PSA) 129.72 ChemAxon Refractivity 56.31 ChemAxon Polarizability 23.69 ChemAxon Rotatable Bond Count 7 ChemAxon H Bond Acceptor Count 6 ChemAxon H Bond Donor Count 5 ChemAxon pKa (strongest acidic) 1.91 ChemAxon pKa (strongest basic) 9.24 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon ChEBI 17515 PubChem Compound 13922647 PubChem Substance 46506032 KEGG Compound C00669 PDB 3GC SMP00136 2-Hydroxyglutric Aciduria (D And L Form) DB00119 Pyruvic acid DB00121 Biotin DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB01972 Guanosine-5'-Monophosphate DB02530 Gamma(Amino)-Butyric Acid DB03408 Gamma-Glutamylcysteine A8YXX4 Q9UI32 P47897 Q06210 Q96EK6 Q9UJ70 P27708 P31327 Q06203 P49915 Q6IA69 P30038 P24298 P00367 P00505 Q5JPH6 P48506 P48507 P48637 P00390 Q99259 P80404 P51649 SMP00243 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency DB00119 Pyruvic acid DB00121 Biotin DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB01972 Guanosine-5'-Monophosphate DB02530 Gamma(Amino)-Butyric Acid DB03408 Gamma-Glutamylcysteine A8YXX4 Q9UI32 P47897 Q06210 Q96EK6 Q9UJ70 P27708 P31327 Q06203 P49915 Q6IA69 P30038 P24298 P00367 P00505 Q5JPH6 P48506 P48507 P48637 P00390 Q99259 P80404 P51649 SMP00500 5-oxoprolinase deficiency DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB01593 Zinc DB03088 Pyroglutamic Acid DB03408 Gamma-Glutamylcysteine P48637 P07203 P00390 Q9H4Y5 Q6P531 P15144 P55210 P48506 P48507 O14841 O75223 SMP00143 5-Oxoprolinuria DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB01593 Zinc DB03088 Pyroglutamic Acid DB03408 Gamma-Glutamylcysteine P48637 P07203 P00390 Q9H4Y5 Q6P531 P15144 P55210 P48506 P48507 O14841 O75223 SMP00499 Beta-mercaptolactate-cysteine disulfiduria DB00119 Pyruvic acid DB00142 L-Glutamic Acid DB00151 L-Cysteine DB01592 Iron DB01593 Zinc DB03408 Gamma-Glutamylcysteine P48506 P48507 Q16878 P17174 P32929 P25325 Q6ZMR3 P49589 O60931 SMP00013 Cysteine Metabolism DB00119 Pyruvic acid DB00142 L-Glutamic Acid DB00151 L-Cysteine DB01592 Iron DB01593 Zinc DB03408 Gamma-Glutamylcysteine P48506 P48507 Q16878 P17174 P32929 P25325 Q6ZMR3 P49589 O60931 SMP00722 Cystinosis, ocular nonnephropathic DB00119 Pyruvic acid DB00142 L-Glutamic Acid DB00151 L-Cysteine DB01592 Iron DB01593 Zinc DB03408 Gamma-Glutamylcysteine P48506 P48507 Q16878 P17174 P32929 P25325 Q6ZMR3 P49589 O60931 SMP00501 Gamma-glutamyl-transpeptidase deficiency DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB01593 Zinc DB03088 Pyroglutamic Acid DB03408 Gamma-Glutamylcysteine P48637 P07203 P00390 Q9H4Y5 Q6P531 P15144 P55210 P48506 P48507 O14841 O75223 SMP00567 Succinic semialdehyde dehydrogenase deficiency DB00119 Pyruvic acid DB00121 Biotin DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB01972 Guanosine-5'-Monophosphate DB02530 Gamma(Amino)-Butyric Acid DB03408 Gamma-Glutamylcysteine A8YXX4 Q9UI32 P47897 Q06210 Q96EK6 Q9UJ70 P27708 P31327 Q06203 P49915 Q6IA69 P30038 P24298 P00367 P00505 Q5JPH6 P48506 P48507 P48637 P00390 Q99259 P80404 P51649 SMP00337 Glutathione Synthetase Deficiency DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB01593 Zinc DB03088 Pyroglutamic Acid DB03408 Gamma-Glutamylcysteine P48637 P07203 P00390 Q9H4Y5 Q6P531 P15144 P55210 P48506 P48507 O14841 O75223 SMP00183 Gamma-Glutamyltransferase Deficiency DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB01593 Zinc DB03088 Pyroglutamic Acid DB03408 Gamma-Glutamylcysteine P48637 P07203 P00390 Q9H4Y5 Q6P531 P15144 P55210 P48506 P48507 O14841 O75223 SMP00072 Glutamate Metabolism DB00119 Pyruvic acid DB00121 Biotin DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB01972 Guanosine-5'-Monophosphate DB02530 Gamma(Amino)-Butyric Acid DB03408 Gamma-Glutamylcysteine A8YXX4 Q9UI32 P47897 Q06210 Q96EK6 Q9UJ70 P27708 P31327 Q06203 P49915 Q6IA69 P30038 P24298 P00367 P00505 Q5JPH6 P48506 P48507 P48637 P00390 Q99259 P80404 P51649 SMP00015 Glutathione Metabolism DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB01593 Zinc DB03088 Pyroglutamic Acid DB03408 Gamma-Glutamylcysteine P48637 P07203 P00390 Q9H4Y5 Q6P531 P15144 P55210 P48506 P48507 O14841 O75223 SMP00385 Homocarnosinosis DB00119 Pyruvic acid DB00121 Biotin DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB01972 Guanosine-5'-Monophosphate DB02530 Gamma(Amino)-Butyric Acid DB03408 Gamma-Glutamylcysteine A8YXX4 Q9UI32 P47897 Q06210 Q96EK6 Q9UJ70 P27708 P31327 Q06203 P49915 Q6IA69 P30038 P24298 P00367 P00505 Q5JPH6 P48506 P48507 P48637 P00390 Q99259 P80404 P51649 SMP00339 Hyperinsulinism-Hyperammonemia Syndrome DB00119 Pyruvic acid DB00121 Biotin DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00143 Glutathione DB00145 Glycine DB00151 L-Cysteine DB00160 L-Alanine DB01593 Zinc DB01972 Guanosine-5'-Monophosphate DB02530 Gamma(Amino)-Butyric Acid DB03408 Gamma-Glutamylcysteine A8YXX4 Q9UI32 P47897 Q06210 Q96EK6 Q9UJ70 P27708 P31327 Q06203 P49915 Q6IA69 P30038 P24298 P00367 P00505 Q5JPH6 P48506 P48507 P48637 P00390 Q99259 P80404 P51649 BE0000185 Glutathione synthetase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Glutathione synthetase Involved in catalytic activity GSS 20q11.2 None 5.73 52385.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:4624 GenAtlas GSS GeneCards GSS GenBank Gene Database L42531 GenBank Protein Database 886284 UniProtKB P48637 UniProt Accession GSHB_HUMAN EC 6.3.2.3 Glutathione synthase GSH synthetase GSH-S >Glutathione synthetase MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSA LLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVF LGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL SNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFE DISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQ LAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSR FVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVV QCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV >1425 bp ATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGG CAGGCCGTGGACCGGGCCCTGGCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACT TCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTCCCCAGTGCC CTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGC CAGAACGCTGCCTTCCTGGAGCAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACC GCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAGACTGTGTTC CTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTG AAACAGATCGAAATCAACACCATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCA GCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGCAAGATCCTC TCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGC TCACCCAATGCTCTGGTGCTACTGATTGCTCAAGAGAAGGAAAGAAACATATTTGACCAG CGTGCCATAGAGAATGAGCTACTGGCCAGGAACATCCATGTGATCCGACGAACATTTGAA GATATCTCTGAAAAGGGGTCTCTGGACCAAGACCGAAGGCTGTTTGTGGATGGCCAGGAA ATTGCTGTGGTTTACTTCCGGGATGGCTACATGCCTCGTCAGTACAGTCTACAGAATTGG GAAGCACGTCTACTGCTGGAGAGGTCACATGCTGCCAAGTGCCCAGACATTGCCACCCAG CTGGCTGGGACTAAGAAGGTGCAGCAGGAGCTAAGCAGGCCGGGCATGCTGGAGATGTTG CTCCCTGGCCAGCCTGAGGCTGTGGCCCGCCTCCGCGCCACCTTTGCTGGCCTCTACTCA CTGGATGTGGGTGAAGAAGGGGACCAGGCCATCGCCGAGGCCCTTGCTGCCCCTAGCCGG TTTGTGCTAAAGCCCCAGAGAGAGGGTGGAGGTAACAACCTATATGGGGAGGAAATGGTA CAGGCCCTGAAACAGCTGAAGGACAGTGAGGAGAGGGCCTCCTACATCCTCATGGAGAAG ATCGAACCTGAGCCTTTTGAGAATTGCCTGCTACGGCCTGGCAGCCCTGCCCGAGTGGTC CAGTGCATTTCAGAGCTGGGCATCTTTGGGGTCTATGTCAGGCAGGAAAAGACACTCGTG ATGAACAAGCACGTGGGGCATCTACTTCGAACCAAAGCCATCGAGCATGCAGATGGTGGT GTGGCAGCGGGAGTGGCAGTCCTGGACAACCCATACCCTGTGTGA PF03917 GSH_synth_ATP PF03199 GSH_synthase function nucleotide binding function glutathione synthase activity function purine nucleotide binding function adenyl nucleotide binding function ATP binding function ligase activity function ligase activity, forming carbon-nitrogen bonds function binding function acid-amino acid ligase activity function catalytic activity process physiological process process cofactor metabolism process coenzyme metabolism process metabolism process glutathione metabolism process cellular metabolism process glutathione biosynthesis "
owl:sameAs	?:Pyruvic acid ?:Biotin ?:L-Aspartic Acid ?:L-Glutamine ?:Succinic acid ?:L-Glutamic Acid ?:Glutathione ?:Glycine ?:L-Cysteine ?:L-Alanine ?:Iron ?:Zinc ?:Guanosine-5'-Monophosphate ?:Gamma(Amino)-Butyric Acid ?:Pyroglutamic Acid ?:Gamma-Glutamylcysteine ?:EXPT00168

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

The resource appears as object in 16 triples

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