Resource Uracil

Predicate	Value (sorted: none)
owl:sameAs	?:Zinc
owl:sameAs	?:Uridine
owl:sameAs	?:L-Histidine
owl:sameAs	?:L-Glutamine
owl:sameAs	?:Beta-Alanine
owl:sameAs	?:Cytidine-5'-Triphosphate
ns1:description	" 66-22-8 experimental Kurt Klemm, Wolfgang Schoetensack, Wolfgang Prusse, "Aryl-substituted piperazinyl-alkylamino-uracils, -uracil ethers and -uracil thioethers and method for their production." U.S. Patent US3957786, issued September, 1951. This compound belongs to the pyrimidones. These are compounds whose pyrimidine ring bears a ketone. Pyrimidones Organic Compounds Heterocyclic Compounds Diazines Pyrimidines and Pyrimidine Derivatives Hydropyrimidines Polyamines hydropyrimidine polyamine organonitrogen compound logP -1.2 ALOGPS logS -0.63 ALOGPS Water Solubility 2.65e+01 g/l ALOGPS logP -0.86 ChemAxon IUPAC Name 1,2,3,4-tetrahydropyrimidine-2,4-dione ChemAxon Traditional IUPAC Name uracil ChemAxon Molecular Weight 112.0868 ChemAxon Monoisotopic Weight 112.027277382 ChemAxon SMILES O=C1NC=CC(=O)N1 ChemAxon Molecular Formula C4H4N2O2 ChemAxon InChI InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) ChemAxon InChIKey InChIKey=ISAKRJDGNUQOIC-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 58.2 ChemAxon Refractivity 25.97 ChemAxon Polarizability 9.37 ChemAxon Rotatable Bond Count 0 ChemAxon H Bond Acceptor Count 2 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 9.77 ChemAxon pKa (strongest basic) -5.5 ChemAxon Physiological Charge 0 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Water Solubility 3600 mg/L (at 25 Â°C) YALKOWSKY,SH & DANNENFELSER,RM (1992) Melting Point 338 Â°C PhysProp logP -1.07 HANSCH,C ET AL. (1995) logS -1.48 ADME Research, USCD caco2 Permeability -5.37 ADME Research, USCD pKa 9.45 MERCK INDEX (1996) ChEBI 17568 PubChem Compound 1174 PubChem Substance 46504697 KEGG Compound C00106 KEGG Drug D00027 PDB URA SMP00219 UMP Synthase Deiciency (Orotic Aciduria) DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00007 Beta-Alanine Metabolism DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00172 Beta Ureidopropionase Deficiency DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00493 Carnosinuria, carnosinemia DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00178 Dihydropyrimidinase Deficiency DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00492 Ureidopropionase deficiency DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00351 GABA-Transaminase Deficiency DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00046 Pyrimidine Metabolism DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 BE0002034 Ribosomal small subunit pseudouridine synthase A Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Ribosomal small subunit pseudouridine synthase A Translation, ribosomal structure and biogenesis Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA rsuA Cytoplasmic None 6.12 25866.0 Escherichia coli (strain K12) GenBank Gene Database U00008 UniProtKB P0AA43 UniProt Accession RSUA_ECOLI 16S pseudouridine 516 synthase 16S pseudouridylate 516 synthase EC 5.4.99.- rRNA pseudouridylate synthase A rRNA- uridine isomerase A >Ribosomal small subunit pseudouridine synthase A MRLDKFIAQQLGVSRAIAGREIRGNRVTVDGEIVRNAAFKLLPEHDVAYDGNPLAQQHGP RYFMLNKPQGYVCSTDDPDHPTVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHR ITSPRHHCEKTYLVTLESPVADDTAEQFAKGVQLHNEKDLTKPAVLEVITPTQVRLTISE GRYHQVKRMFAAVGNHVVELHRERIGGITLDADLAPGEYRPLTEEEIASVV PF01479 S4 PF00849 PseudoU_synth_2 function catalytic activity function intramolecular transferase activity function pseudouridylate synthase activity function pseudouridine synthase activity function lyase activity function nucleic acid binding function RNA binding function isomerase activity function binding function carbon-oxygen lyase activity function hydro-lyase activity process metabolism process cellular metabolism process RNA processing process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process RNA metabolism process physiological process BE0001918 Uracil-DNA glycosylase HHV-1 # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Uracil-DNA glycosylase Coenzyme transport and metabolism Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine UL2 Cytoplasmic None 9.61 36329.0 HHV-1 GenBank Gene Database X14112 GenBank Protein Database 59502 UniProtKB P10186 UniProt Accession UNG_HHV11 EC 3.2.2.- UDG >Uracil-DNA glycosylase MKRACSRSPSPRRRPSSPRRTPPRDGTPPQKADADDPTPGASNDASTETRPGSGGEPAAC RSSGPAALLAALEAGPAGVTFSSSAPPDPPMDLTNGGVSPAATSAPLDWTTFRRVFLIDD AWRPLMEPELANPLTAHLLAEYNRRCQTEEVLPPREDVFSWTRYCTPDEVRVVIIGQDPY HHPGQAHGLAFSVRANVPPPPSLRNVLAAVKNCYPEARMSGHGCLEKWARDGVLLLNTTL TVKRGAAASHSRIGWDRFVGGVIRRLAARRPGLVFMLWGTHAQNAIRPDPRVHCVLKFSH PSPLSKVPFGTCQHFLVANRYLETRSISPIDWSV >1005 bp ATGAAGCGGGCCTGCAGCCGAAGCCCCTCACCACGCCGCCGCCCATCATCGCCACGTCGG ACCCCACCCCGCGACGGGACGCCGCCACAAAAAGCAGACGCCGACGACCCCACTCCCGGC GCCTCTAACGATGCCTCGACGGAAACCCGTCCGGGTTCGGGGGGCGAACCGGCCGCCTGT CGCTCGTCAGGGCCGGCGGCGCTCCTCGCCGCCCTAGAGGCTGGTCCCGCTGGTGTGACG TTTTCCTCGTCCGCGCCCCCCGACCCTCCCATGGATTTAACAAACGGGGGGGTGTCGCCT GCGGCGACCTCGGCGCCTCTGGACTGGACCACGTTTCGGCGTGTGTTTCTGATCGACGAC GCGTGGCGGCCCCTGATGGAGCCTGAGCTGGCGAACCCCTTAACCGCCCACCTCCTGGCC GAATATAATCGTCGGTGCCAGACCGAAGAGGTGCTGCCGCCGCGGGAGGATGTGTTTTCG TGGACTCGTTATTGCACCCCCGACGAGGTGCGCGTGGTTATCATCGGCCAGGACCCATAT CACCACCCCGGCCAGGCGCACGGACTTGCGTTTAGCGTGCGCGCGAACGTGCCGCCTCCC CCGAGTCTTCGGAATGTCTTGGCGGCCGTCAAGAACTGTTATCCCGAGGCACGGATGAGC GGCCACGGTTGCCTGGAAAAGTGGGCGCGGGACGGCGTCCTGTTACTAAACACGACCCTG ACCGTCAAGCGCGGGGCGGCGGCGTCCCACTCTAGAATCGGTTGGGACCGTTTCGTGGGC GGAGTTATCCGCCGGTTGGCCGCGCGCCGCCCCGGCCTGGTGTTTATGCTCTGGGGCACA CACGCCCAGAATGCCATCAGGCCGGACCCTCGGGTCCATTGCGTCCTCAAGTTTTCGCAC CCGTCGCCCCTCTCCAAGGTTCCGTTCGGAACCTGCCAGCATTTCCTCGTGGCGAACCGA TACCTCGAGACCCGGTCGATTTCACCCATCGACTGGTCGGTTTGA PF03167 UDG function hydrolase activity function hydrolase activity, acting on glycosyl bonds function hydrolase activity, hydrolyzing N-glycosyl compounds function DNA N-glycosylase activity function uracil DNA N-glycosylase activity function catalytic activity process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process DNA metabolism process DNA repair process physiological process BE0001925 Uracil-DNA glycosylase Escherichia coli O157:H7 # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Uracil-DNA glycosylase Replication, recombination and repair Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung Cytoplasm None 7.06 25662.0 Escherichia coli O157:H7 GenBank Gene Database AE005174 GenBank Protein Database 12517001 UniProtKB Q8X444 UniProt Accession UNG_ECO57 EC 3.2.2.- UDG >Uracil-DNA glycosylase MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVI LGQDPYHGPGQAHGLAFSVRPGIATPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVL LLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRH HVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQHGETPIDWMPVLPAESE >690 bp ATGGCTAACGAATTAACCTGGCATGACGTGCTGGCTGAAGAGAAGCAGCAACCCTATTTT CTTAATACCCTTCAGACCGTCGCCAGCGAGCGGCAGTCCGGCGTCACTATCTATCCACCA CAAAAAGATGTCTTTAACGCGTTCCGCTTTACCGAGTTGGGTGACGTTAAAGTGGTGATT CTCGGCCAGGATCCTTATCACGGACCGGGACAGGCGCATGGGCTGGCATTTTCCGTTCGC CCCGGAATCGCCACTCCTCCGTCACTGCTGAATATGTATAAAGAGCTGGAAAATACTATT CCGGGCTTCACCCGCCCTAATCATGGTTATCTTGAAAGCTGGGCGCGTCAGGGCGTTCTG CTACTCAATACTGTGTTGACGGTACGCGCAGGTCAGGCGCATTCCCACGCCAGCCTCGGC TGGGAAACCTTCACCGATAAAGTGATCAGCCTGATTAACCAGCATCGCGAAGGCGTGGTG TTTTTGTTGTGGGGATCGCATGCGCAAAAGAAAGGGGCGATTATAGATAAGCAACGCCAT CATGTACTGAAAGCACCGCATCCGTCGCCGCTTTCGGCTCATCGTGGATTCTTTGGCTGC AACCATTTTGTGCTGGCAAATCAGTGGCTGGAACAACATGGCGAGACGCCGATTGACTGG ATGCCAGTATTACCGGCAGAGAGTGAGTAA PF03167 UDG function hydrolase activity, acting on glycosyl bonds function hydrolase activity, hydrolyzing N-glycosyl compounds function DNA N-glycosylase activity function uracil DNA N-glycosylase activity function catalytic activity function hydrolase activity process DNA metabolism process DNA repair process physiological process process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism BE0000960 Dihydropyrimidine dehydrogenase [NADP(+)] Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Dihydropyrimidine dehydrogenase [NADP(+)] Amino acid transport and metabolism Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil DPYD 1p22 Cytoplasm None 7.05 111375.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:3012 GenAtlas DPYD GeneCards DPYD GenBank Gene Database U09178 GenBank Protein Database 558305 UniProtKB Q12882 UniProt Accession DPYD_HUMAN DHPDHase Dihydropyrimidine dehydrogenase precursor Dihydrothymine dehydrogenase Dihydrouracil dehydrogenase DPD EC 1.3.1.2 >Dihydropyrimidine dehydrogenase [NADP+] precursor MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ NVAFSPLKRSCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS VNPVC >3078 bp ATGGCCCCTGTGCTCAGTAAGGACTCGGCGGACATCGAGAGTATCCTGGCTTTAAATCCT CGAACACAAACTCATGCAACTCTGTGTTCCACTTCGGCCAAGAAATTAGACAAGAAACAT TGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGTGAGAAGCTGGAGAATAATTTTGAT GACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTG AAATGTGCAGATGCCCCGTGTCAGAAGAGCTGTCCAACTAATCTTGATATTAAATCATTC ATCACAAGTATTGCAAACAAGAACTATTATGGAGCTGCTAAGATGATATTTTCTGACAAC CCACTTGGTCTGACTTGTGGAATGGTATGTCCAACCTCTGATCTATGTGTAGGTGGATGC AATTTATATGCCACTGAAGAGGGACCCATTAATATTGGTGGATTGCAGCAATTTGCTACT GAGGTATTCAAAGCAATGAGTATCCCACAGATCAGAAATCCTTCGCTGCCTCCCCCAGAA AAAATGTCTGAAGCCTATTCTGCAAAGATTGCTCTTTTTGGTGCTGGGCCTGCAAGTATA AGTTGTGCTTCCTTTTTGGCTCGATTGGGGTACTCTGACATCACTATATTTGAAAAACAA GAATATGTTGGTGGTTTAAGTACTTCTGAAATTCCTCAGTTCCGGCTGCCGTATGATGTA GTGAATTTTGAGATTGAGCTAATGAAGGACCTTGGTGTAAAGATAATTTGCGGTAAAAGC CTTTCAGTGAATGAAATGACTCTTAGCACTTTGAAAGAAAAAGGCTACAAAGCTGCTTTC ATTGGAATAGGTTTGCCAGAACCCAATAAAGATGCCATCTTCCAAGGCCTGACGCAGGAC CAGGGGTTTTATACATCCAAAGACTTTTTGCCACTTGTAGCCAAAGGCAGTAAAGCAGGA ATGTGCGCCTGTCACTCTCCATTGCCATCGATACGGGGAGTCGTGATTGTACTTGGAGCT GGAGACACTGCCTTCGACTGTGCAACATCTGCTCTACGTTGTGGAGCTCGCCGAGTGTTC ATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGATGGAGCTTGCT AAGGAAGAAAAGTGTGAATTTCTGCCATTCCTGTCCCCACGGAAGGTTATAGTAAAAGGT GGGAGAATTGTTGCTATGCAGTTTGTTCGGACAGAGCAAGATGAAACTGGAAAATGGAAT GAAGATGAAGATCAGATGGTCCATCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGTTCA GTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAAAATTTAACAGATGGGGT CTCCCAGAAGTAGATCCAGAAACTATGCAAACTAGTGAAGCATGGGTATTTGCAGGTGGT GATGTCGTTGGTTTGGCTAACACTACAGTGGAATCGGTGAATGATGGAAAGCAAGCTTCT TGGTACATTCACAAATACGTACAGTCACAATATGGAGCTTCCGTTTCTGCCAAGCCTGAA CTACCCCTCTTTTACACTCCTATTGATCTGGTGGACATTAGTGTAGAAATGGCCGGATTG AAGTTTATAAATCCTTTTGGTCTTGCTAGCGCAACTCCAGCCACCAGCACATCAATGATT CGAAGAGCTTTTGAAGCTGGATGGGGTTTTGCCCTCACCAAAACTTTCTCTCTTGATAAG GACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCACCTCTGGCCCCATGTAT GGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATAT TGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTCCCAGACAACATTGTGATTGCTAGC ATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCAAGAAGTCTGAGGATTCT GGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATG GGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCTGCCGCTGGGTTAGGCAA GCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCACTGATATTGTGAGCATC GCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGT CTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGGGGATTGCAAAGCGAACT ACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCC ATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAA AGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAG AATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTG AAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAG AAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGA CCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAA AATGTAGCTTTTTCACCACTTAAGAGAAGCTGTTTTATCCCCAAAAGGCCTATTCCTACC ATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAAC GTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTAC ATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCC ACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGAC TGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCT GTGAATCCGGTGTGTTAA PF00037 Fer4 PF07992 Pyr_redox_2 PF01180 DHO_dh component cell component intracellular component cytoplasm component membrane function oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor function catalytic activity function dihydroorotate oxidase activity function oxidoreductase activity function ion binding function cation binding function transition metal ion binding function iron ion binding function oxidoreductase activity, acting on the CH-CH group of donors function transporter activity function disulfide oxidoreductase activity function binding function electron transporter activity function dihydroorotate dehydrogenase activity process generation of precursor metabolites and energy process electron transport process metabolism process pyrimidine base metabolism process cellular metabolism process pyrimidine base biosynthesis process 'de novo' pyrimidine base biosynthesis process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process nucleobase metabolism process physiological process BE0004582 Uridine-cytidine kinase-like 1 Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Uridine-cytidine kinase-like 1 UCKL1 Human UniProtKB Q9NWZ5 UniProt Accession UCKL1_HUMAN BE0003080 Uracil-DNA glycosylase Thermus thermophilus unknown Uracil-DNA glycosylase Replication, recombination and repair udg None 9.25 22966.0 Thermus thermophilus GenBank Gene Database AB109239 UniProtKB Q7WYV4 UniProt Accession Q7WYV4_THETH >Uracil-DNA glycosylase MTLELLQAQAQNCTACRLMEGRTRVVFGEGNPDAKLMIVGEGPGEEEDKTGRPFVGKAGQ LLNRILEAAGIPREEVYITNIVKCRPPQNRAPLPDEAKICTDKWLLKQIELIAPQIIVPL GAVAAEFFLGEKVSITKVRGKWYEWHGIKVFPMFHPAYLLRNPSRAPGSPKHLTWLDIQE VKRALDALPPKERRPVKAVSQEPLF >618 bp ATGACCCTGGAACTGCTTCAGGCCCAGGCGCAAAACTGCACCGCCTGCCGCCTCATGGAG GGCCGGACCCGGGTGGTCTTCGGGGAGGGAAACCCGGACGCAAAGCTCATGATCGTGGGG GAAGGCCCCGGGGAGGAGGAGGACAAGACGGGCCGCCCCTTCGTGGGCAAGGCGGGGCAG CTTCTAAACCGCATCCTGGAGGCGGCGGGGATCCCCAGGGAGGAGGTCTACATCACCAAC ATCGTCAAGTGCCGCCCCCCGCAAAACCGCGCCCCCCTTCCCGACGAGGCCAAGATCTGC ACGGACAAGTGGCTCCTCAAGCAGATTGAGCTCATCGCCCCCCAGATCATCGTCCCCTTG GGGGCGGTGGCCGCCGAGTTCTTCCTGGGGGAGAAGGTCTCCATCACCAAGGTCCGGGGG AAGTGGTACGAGTGGCACGGGATCAAGGTCTTCCCCATGTTCCACCCCGCCTACCTCCTC AGGAACCCGAGCCGGGCCCCGGGAAGCCCCAAGCACCTCACCTGGCTGGACATCCAAGAG GTCAAGCGGGCCCTGGACGCCCTCCCTCCCAAGGAGCGGCGCCCGGTGAAGGCGGTGAGC CAGGAGCCCCTCTTCTAA PF03167 UDG BE0003081 Pyrimidine-nucleoside phosphorylase Geobacillus stearothermophilus unknown Pyrimidine-nucleoside phosphorylase Involved in transferase activity, transferring glycosyl groups A pyrimidine nucleoside + phosphate = a pyrimidine base + alpha-D-ribose 1-phosphate pdp None 5.04 46333.0 Geobacillus stearothermophilus GenBank Gene Database D87961 UniProtKB P77836 UniProt Accession PDP_GEOSE EC 2.4.2.2 PYNP >Pyrimidine-nucleoside phosphorylase MRMVDLIEKKRDGHALTKEEIQFIIEGYTKGDIPDYQMSALAMAIFFRGMNEEETAELTM AMVHSGDTIDLSRIEGIKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGT IDKLESVPGFHVEITNDEFIDLVNKNKIAVVGQSGNLTPADKKLYALRDVTATVNSIPLI ASSIMSKKIAAGADAIVLDVKTGVGAFMKDLNDAKALAKAMVDIGNRVGRKTMAIISDMS QPLGYAIGNALEVKEAIDTLKGEGPEDFQELCLVLGSHMVYLAEKASSLEEARHMLEKAM KDGSALQTFKTFLAAQGGDASVVDDPSKLPQAKYIIELEAKEDGYVSEIVADAVGTAAMW LGAGRATKESTIDLAVGLVLRKKVGDAVKKGESLVTIYSNREQVDDVKQKLYENIRISAT PVQAPTLIYDKIS >1302 bp ATGAGAATGGTCGATTTAATTGAGAAAAAACGTGATGGTCATGCGTTAACGAAAGAAGAA ATTCAGTTTATTATTGAAGGTTACACAAAAGGCGATATTCCTGATTATCAAATGAGCGCA TTAGCGATGGCGATTTTTTTCCGCGGCATGAATGAAGAAGAGACAGCGGAATTGACGATG GCGATGGTGCATTCAGGCGATACGATCGACCTTTCGCGAATTGAAGGAATTAAAGTAGAC AAACATTCAACGGGCGGAGTGGGCGATACAACAACGTTAGTGCTTGGCCCTCTTGTCGCC TCCGTCGGTGTTCCGGTTGCGAAAATGTCTGGGCGCGGCCTTGGACATACGGGTGGAACG ATCGACAAACTAGAATCGGTGCCAGGTTTTCACGTTGAAATTACGAACGATGAATTTATC GATCTTGTCAATAAAAATAAAATTGCCGTTGTCGGTCAGTCTGGTAATTTGACGCCAGCG GACAAAAAGTTGTATGCGCTTCGTGATGTGACGGCAACGGTCAATAGCATTCCGTTAATT GCCTCATCGATTATGAGCAAAAAAATTGCCGCAGGGGCAGATGCGATCGTACTTGACGTA AAAACAGGTGTGGGCGCGTTTATGAAAGATTTAAACGATGCAAAAGCATTAGCGAAAGCG ATGGTCGATATCGGAAATCGGGTTGGGCGTAAAACGATGGCAATTATTTCTGATATGAGC CAGCCGCTTGGTTATGCCATTGGAAATGCGCTTGAAGTGAAAGAAGCGATTGATACGTTA AAAGGAGAAGGTCCAGAAGATTTCCAAGAGCTGTGCTTAGTGCTTGGTAGCCACATGGTA TATTTAGCGGAAAAAGCATCTTCGCTTGAAGAAGCTCGTCATATGTTAGAAAAAGCGATG AAAGACGGTTCAGCCCTTCAAACATTTAAAACGTTCTTAGCTGCGCAAGGTGGCGATGCA TCTGTTGTCGATGACCCAAGCAAATTGCCGCAAGCAAAATATATTATTGAACTAGAAGCG AAAGAAGATGGATACGTATCCGAAATTGTCGCGGATGCGGTCGGAACGGCGGCGATGTGG CTTGGTGCAGGGCGAGCGACGAAAGAATCAACGATCGATTTAGCTGTCGGTCTCGTGCTT CGCAAAAAAGTCGGCGATGCGGTGAAAAAAGGTGAATCGCTCGTTACAATTTACAGCAAC CGTGAACAAGTGGATGATGTAAAACAAAAACTATATGAAAACATTCGTATTTCAGCAACA CCTGTTCAAGCTCCAACATTAATTTACGATAAAATTTCGTAA PF02885 Glycos_trans_3N PF00591 Glycos_transf_3 PF07831 PYNP_C function transferase activity function transferase activity, transferring glycosyl groups function catalytic activity process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process nucleobase metabolism process pyrimidine base metabolism process physiological process "
owl:sameAs	?:Uridine-5'-Diphosphate
owl:sameAs	?:Deoxythymidine
owl:sameAs	?:Riboflavin Monophosphate
rdf:type	ns1:drugs
owl:sameAs	?:L-Aspartic Acid
owl:sameAs	?:Iron
owl:sameAs	?:Orotidine-5'-Monophosphate
rdfs:label	"Uracil"
owl:sameAs	?:Calcium
owl:sameAs	?:L-Glutamic Acid
owl:sameAs	?:EXPT03201
owl:sameAs	?:Uracil
owl:sameAs	?:Uridine-5'-Monophosphate

" 66-22-8 experimental Kurt Klemm, Wolfgang Schoetensack, Wolfgang Prusse, "Aryl-substituted piperazinyl-alkylamino-uracils, -uracil ethers and -uracil thioethers and method for their production." U.S. Patent US3957786, issued September, 1951. This compound belongs to the pyrimidones. These are compounds whose pyrimidine ring bears a ketone. Pyrimidones Organic Compounds Heterocyclic Compounds Diazines Pyrimidines and Pyrimidine Derivatives Hydropyrimidines Polyamines hydropyrimidine polyamine organonitrogen compound logP -1.2 ALOGPS logS -0.63 ALOGPS Water Solubility 2.65e+01 g/l ALOGPS logP -0.86 ChemAxon IUPAC Name 1,2,3,4-tetrahydropyrimidine-2,4-dione ChemAxon Traditional IUPAC Name uracil ChemAxon Molecular Weight 112.0868 ChemAxon Monoisotopic Weight 112.027277382 ChemAxon SMILES O=C1NC=CC(=O)N1 ChemAxon Molecular Formula C4H4N2O2 ChemAxon InChI InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) ChemAxon InChIKey InChIKey=ISAKRJDGNUQOIC-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 58.2 ChemAxon Refractivity 25.97 ChemAxon Polarizability 9.37 ChemAxon Rotatable Bond Count 0 ChemAxon H Bond Acceptor Count 2 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 9.77 ChemAxon pKa (strongest basic) -5.5 ChemAxon Physiological Charge 0 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Water Solubility 3600 mg/L (at 25 Â°C) YALKOWSKY,SH & DANNENFELSER,RM (1992) Melting Point 338 Â°C PhysProp logP -1.07 HANSCH,C ET AL. (1995) logS -1.48 ADME Research, USCD caco2 Permeability -5.37 ADME Research, USCD pKa 9.45 MERCK INDEX (1996) ChEBI 17568 PubChem Compound 1174 PubChem Substance 46504697 KEGG Compound C00106 KEGG Drug D00027 PDB URA SMP00219 UMP Synthase Deiciency (Orotic Aciduria) DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00007 Beta-Alanine Metabolism DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00172 Beta Ureidopropionase Deficiency DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00493 Carnosinuria, carnosinemia DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00178 Dihydropyrimidinase Deficiency DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00492 Ureidopropionase deficiency DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00351 GABA-Transaminase Deficiency DB00117 L-Histidine DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB01373 Calcium DB01593 Zinc DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil Q96KN2 Q99259 Q9UBR1 Q14117 Q12882 P80404 Q02252 P05091 Q16853 SMP00202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 SMP00046 Pyrimidine Metabolism DB00130 L-Glutamine DB01373 Calcium DB01592 Iron DB01593 Zinc DB02431 Cytidine-5'-Triphosphate DB02745 Uridine DB02957 Orotidine-5'-Monophosphate DB03107 Beta-Alanine DB03247 Riboflavin Monophosphate DB03419 Uracil DB03435 Uridine-5'-Diphosphate DB03685 Uridine-5'-Monophosphate DB04485 Deoxythymidine P27708 Q02127 A8K5J1 Q8WVQ1 Q5EBM0 O75414 Q9UIJ7 Q9BY32 P17812 P49902 Q9Y2T3 O95045 Q12882 Q14117 Q9UBR1 P31350 Q7LG56 Q9NWZ5 P32320 P19971 P32321 P04183 P04818 P33316 BE0002034 Ribosomal small subunit pseudouridine synthase A Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Ribosomal small subunit pseudouridine synthase A Translation, ribosomal structure and biogenesis Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA rsuA Cytoplasmic None 6.12 25866.0 Escherichia coli (strain K12) GenBank Gene Database U00008 UniProtKB P0AA43 UniProt Accession RSUA_ECOLI 16S pseudouridine 516 synthase 16S pseudouridylate 516 synthase EC 5.4.99.- rRNA pseudouridylate synthase A rRNA- uridine isomerase A >Ribosomal small subunit pseudouridine synthase A MRLDKFIAQQLGVSRAIAGREIRGNRVTVDGEIVRNAAFKLLPEHDVAYDGNPLAQQHGP RYFMLNKPQGYVCSTDDPDHPTVLYFLDEPVAWKLHAAGRLDIDTTGLVLMTDDGQWSHR ITSPRHHCEKTYLVTLESPVADDTAEQFAKGVQLHNEKDLTKPAVLEVITPTQVRLTISE GRYHQVKRMFAAVGNHVVELHRERIGGITLDADLAPGEYRPLTEEEIASVV PF01479 S4 PF00849 PseudoU_synth_2 function catalytic activity function intramolecular transferase activity function pseudouridylate synthase activity function pseudouridine synthase activity function lyase activity function nucleic acid binding function RNA binding function isomerase activity function binding function carbon-oxygen lyase activity function hydro-lyase activity process metabolism process cellular metabolism process RNA processing process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process RNA metabolism process physiological process BE0001918 Uracil-DNA glycosylase HHV-1 # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Uracil-DNA glycosylase Coenzyme transport and metabolism Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine UL2 Cytoplasmic None 9.61 36329.0 HHV-1 GenBank Gene Database X14112 GenBank Protein Database 59502 UniProtKB P10186 UniProt Accession UNG_HHV11 EC 3.2.2.- UDG >Uracil-DNA glycosylase MKRACSRSPSPRRRPSSPRRTPPRDGTPPQKADADDPTPGASNDASTETRPGSGGEPAAC RSSGPAALLAALEAGPAGVTFSSSAPPDPPMDLTNGGVSPAATSAPLDWTTFRRVFLIDD AWRPLMEPELANPLTAHLLAEYNRRCQTEEVLPPREDVFSWTRYCTPDEVRVVIIGQDPY HHPGQAHGLAFSVRANVPPPPSLRNVLAAVKNCYPEARMSGHGCLEKWARDGVLLLNTTL TVKRGAAASHSRIGWDRFVGGVIRRLAARRPGLVFMLWGTHAQNAIRPDPRVHCVLKFSH PSPLSKVPFGTCQHFLVANRYLETRSISPIDWSV >1005 bp ATGAAGCGGGCCTGCAGCCGAAGCCCCTCACCACGCCGCCGCCCATCATCGCCACGTCGG ACCCCACCCCGCGACGGGACGCCGCCACAAAAAGCAGACGCCGACGACCCCACTCCCGGC GCCTCTAACGATGCCTCGACGGAAACCCGTCCGGGTTCGGGGGGCGAACCGGCCGCCTGT CGCTCGTCAGGGCCGGCGGCGCTCCTCGCCGCCCTAGAGGCTGGTCCCGCTGGTGTGACG TTTTCCTCGTCCGCGCCCCCCGACCCTCCCATGGATTTAACAAACGGGGGGGTGTCGCCT GCGGCGACCTCGGCGCCTCTGGACTGGACCACGTTTCGGCGTGTGTTTCTGATCGACGAC GCGTGGCGGCCCCTGATGGAGCCTGAGCTGGCGAACCCCTTAACCGCCCACCTCCTGGCC GAATATAATCGTCGGTGCCAGACCGAAGAGGTGCTGCCGCCGCGGGAGGATGTGTTTTCG TGGACTCGTTATTGCACCCCCGACGAGGTGCGCGTGGTTATCATCGGCCAGGACCCATAT CACCACCCCGGCCAGGCGCACGGACTTGCGTTTAGCGTGCGCGCGAACGTGCCGCCTCCC CCGAGTCTTCGGAATGTCTTGGCGGCCGTCAAGAACTGTTATCCCGAGGCACGGATGAGC GGCCACGGTTGCCTGGAAAAGTGGGCGCGGGACGGCGTCCTGTTACTAAACACGACCCTG ACCGTCAAGCGCGGGGCGGCGGCGTCCCACTCTAGAATCGGTTGGGACCGTTTCGTGGGC GGAGTTATCCGCCGGTTGGCCGCGCGCCGCCCCGGCCTGGTGTTTATGCTCTGGGGCACA CACGCCCAGAATGCCATCAGGCCGGACCCTCGGGTCCATTGCGTCCTCAAGTTTTCGCAC CCGTCGCCCCTCTCCAAGGTTCCGTTCGGAACCTGCCAGCATTTCCTCGTGGCGAACCGA TACCTCGAGACCCGGTCGATTTCACCCATCGACTGGTCGGTTTGA PF03167 UDG function hydrolase activity function hydrolase activity, acting on glycosyl bonds function hydrolase activity, hydrolyzing N-glycosyl compounds function DNA N-glycosylase activity function uracil DNA N-glycosylase activity function catalytic activity process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process DNA metabolism process DNA repair process physiological process BE0001925 Uracil-DNA glycosylase Escherichia coli O157:H7 # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Uracil-DNA glycosylase Replication, recombination and repair Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung Cytoplasm None 7.06 25662.0 Escherichia coli O157:H7 GenBank Gene Database AE005174 GenBank Protein Database 12517001 UniProtKB Q8X444 UniProt Accession UNG_ECO57 EC 3.2.2.- UDG >Uracil-DNA glycosylase MANELTWHDVLAEEKQQPYFLNTLQTVASERQSGVTIYPPQKDVFNAFRFTELGDVKVVI LGQDPYHGPGQAHGLAFSVRPGIATPPSLLNMYKELENTIPGFTRPNHGYLESWARQGVL LLNTVLTVRAGQAHSHASLGWETFTDKVISLINQHREGVVFLLWGSHAQKKGAIIDKQRH HVLKAPHPSPLSAHRGFFGCNHFVLANQWLEQHGETPIDWMPVLPAESE >690 bp ATGGCTAACGAATTAACCTGGCATGACGTGCTGGCTGAAGAGAAGCAGCAACCCTATTTT CTTAATACCCTTCAGACCGTCGCCAGCGAGCGGCAGTCCGGCGTCACTATCTATCCACCA CAAAAAGATGTCTTTAACGCGTTCCGCTTTACCGAGTTGGGTGACGTTAAAGTGGTGATT CTCGGCCAGGATCCTTATCACGGACCGGGACAGGCGCATGGGCTGGCATTTTCCGTTCGC CCCGGAATCGCCACTCCTCCGTCACTGCTGAATATGTATAAAGAGCTGGAAAATACTATT CCGGGCTTCACCCGCCCTAATCATGGTTATCTTGAAAGCTGGGCGCGTCAGGGCGTTCTG CTACTCAATACTGTGTTGACGGTACGCGCAGGTCAGGCGCATTCCCACGCCAGCCTCGGC TGGGAAACCTTCACCGATAAAGTGATCAGCCTGATTAACCAGCATCGCGAAGGCGTGGTG TTTTTGTTGTGGGGATCGCATGCGCAAAAGAAAGGGGCGATTATAGATAAGCAACGCCAT CATGTACTGAAAGCACCGCATCCGTCGCCGCTTTCGGCTCATCGTGGATTCTTTGGCTGC AACCATTTTGTGCTGGCAAATCAGTGGCTGGAACAACATGGCGAGACGCCGATTGACTGG ATGCCAGTATTACCGGCAGAGAGTGAGTAA PF03167 UDG function hydrolase activity, acting on glycosyl bonds function hydrolase activity, hydrolyzing N-glycosyl compounds function DNA N-glycosylase activity function uracil DNA N-glycosylase activity function catalytic activity function hydrolase activity process DNA metabolism process DNA repair process physiological process process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism BE0000960 Dihydropyrimidine dehydrogenase [NADP(+)] Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Dihydropyrimidine dehydrogenase [NADP(+)] Amino acid transport and metabolism Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil DPYD 1p22 Cytoplasm None 7.05 111375.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:3012 GenAtlas DPYD GeneCards DPYD GenBank Gene Database U09178 GenBank Protein Database 558305 UniProtKB Q12882 UniProt Accession DPYD_HUMAN DHPDHase Dihydropyrimidine dehydrogenase precursor Dihydrothymine dehydrogenase Dihydrouracil dehydrogenase DPD EC 1.3.1.2 >Dihydropyrimidine dehydrogenase [NADP+] precursor MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ NVAFSPLKRSCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS VNPVC >3078 bp ATGGCCCCTGTGCTCAGTAAGGACTCGGCGGACATCGAGAGTATCCTGGCTTTAAATCCT CGAACACAAACTCATGCAACTCTGTGTTCCACTTCGGCCAAGAAATTAGACAAGAAACAT TGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGTGAGAAGCTGGAGAATAATTTTGAT GACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTG AAATGTGCAGATGCCCCGTGTCAGAAGAGCTGTCCAACTAATCTTGATATTAAATCATTC ATCACAAGTATTGCAAACAAGAACTATTATGGAGCTGCTAAGATGATATTTTCTGACAAC CCACTTGGTCTGACTTGTGGAATGGTATGTCCAACCTCTGATCTATGTGTAGGTGGATGC AATTTATATGCCACTGAAGAGGGACCCATTAATATTGGTGGATTGCAGCAATTTGCTACT GAGGTATTCAAAGCAATGAGTATCCCACAGATCAGAAATCCTTCGCTGCCTCCCCCAGAA AAAATGTCTGAAGCCTATTCTGCAAAGATTGCTCTTTTTGGTGCTGGGCCTGCAAGTATA AGTTGTGCTTCCTTTTTGGCTCGATTGGGGTACTCTGACATCACTATATTTGAAAAACAA GAATATGTTGGTGGTTTAAGTACTTCTGAAATTCCTCAGTTCCGGCTGCCGTATGATGTA GTGAATTTTGAGATTGAGCTAATGAAGGACCTTGGTGTAAAGATAATTTGCGGTAAAAGC CTTTCAGTGAATGAAATGACTCTTAGCACTTTGAAAGAAAAAGGCTACAAAGCTGCTTTC ATTGGAATAGGTTTGCCAGAACCCAATAAAGATGCCATCTTCCAAGGCCTGACGCAGGAC CAGGGGTTTTATACATCCAAAGACTTTTTGCCACTTGTAGCCAAAGGCAGTAAAGCAGGA ATGTGCGCCTGTCACTCTCCATTGCCATCGATACGGGGAGTCGTGATTGTACTTGGAGCT GGAGACACTGCCTTCGACTGTGCAACATCTGCTCTACGTTGTGGAGCTCGCCGAGTGTTC ATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGATGGAGCTTGCT AAGGAAGAAAAGTGTGAATTTCTGCCATTCCTGTCCCCACGGAAGGTTATAGTAAAAGGT GGGAGAATTGTTGCTATGCAGTTTGTTCGGACAGAGCAAGATGAAACTGGAAAATGGAAT GAAGATGAAGATCAGATGGTCCATCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGTTCA GTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAAAATTTAACAGATGGGGT CTCCCAGAAGTAGATCCAGAAACTATGCAAACTAGTGAAGCATGGGTATTTGCAGGTGGT GATGTCGTTGGTTTGGCTAACACTACAGTGGAATCGGTGAATGATGGAAAGCAAGCTTCT TGGTACATTCACAAATACGTACAGTCACAATATGGAGCTTCCGTTTCTGCCAAGCCTGAA CTACCCCTCTTTTACACTCCTATTGATCTGGTGGACATTAGTGTAGAAATGGCCGGATTG AAGTTTATAAATCCTTTTGGTCTTGCTAGCGCAACTCCAGCCACCAGCACATCAATGATT CGAAGAGCTTTTGAAGCTGGATGGGGTTTTGCCCTCACCAAAACTTTCTCTCTTGATAAG GACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCACCTCTGGCCCCATGTAT GGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATAT TGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTCCCAGACAACATTGTGATTGCTAGC ATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCAAGAAGTCTGAGGATTCT GGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATG GGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCTGCCGCTGGGTTAGGCAA GCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCACTGATATTGTGAGCATC GCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGT CTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGGGGATTGCAAAGCGAACT ACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCC ATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAA AGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAG AATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTG AAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAG AAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGA CCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAA AATGTAGCTTTTTCACCACTTAAGAGAAGCTGTTTTATCCCCAAAAGGCCTATTCCTACC ATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAAC GTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTAC ATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCC ACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGAC TGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCT GTGAATCCGGTGTGTTAA PF00037 Fer4 PF07992 Pyr_redox_2 PF01180 DHO_dh component cell component intracellular component cytoplasm component membrane function oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor function catalytic activity function dihydroorotate oxidase activity function oxidoreductase activity function ion binding function cation binding function transition metal ion binding function iron ion binding function oxidoreductase activity, acting on the CH-CH group of donors function transporter activity function disulfide oxidoreductase activity function binding function electron transporter activity function dihydroorotate dehydrogenase activity process generation of precursor metabolites and energy process electron transport process metabolism process pyrimidine base metabolism process cellular metabolism process pyrimidine base biosynthesis process 'de novo' pyrimidine base biosynthesis process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process nucleobase metabolism process physiological process BE0004582 Uridine-cytidine kinase-like 1 Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Uridine-cytidine kinase-like 1 UCKL1 Human UniProtKB Q9NWZ5 UniProt Accession UCKL1_HUMAN BE0003080 Uracil-DNA glycosylase Thermus thermophilus unknown Uracil-DNA glycosylase Replication, recombination and repair udg None 9.25 22966.0 Thermus thermophilus GenBank Gene Database AB109239 UniProtKB Q7WYV4 UniProt Accession Q7WYV4_THETH >Uracil-DNA glycosylase MTLELLQAQAQNCTACRLMEGRTRVVFGEGNPDAKLMIVGEGPGEEEDKTGRPFVGKAGQ LLNRILEAAGIPREEVYITNIVKCRPPQNRAPLPDEAKICTDKWLLKQIELIAPQIIVPL GAVAAEFFLGEKVSITKVRGKWYEWHGIKVFPMFHPAYLLRNPSRAPGSPKHLTWLDIQE VKRALDALPPKERRPVKAVSQEPLF >618 bp ATGACCCTGGAACTGCTTCAGGCCCAGGCGCAAAACTGCACCGCCTGCCGCCTCATGGAG GGCCGGACCCGGGTGGTCTTCGGGGAGGGAAACCCGGACGCAAAGCTCATGATCGTGGGG GAAGGCCCCGGGGAGGAGGAGGACAAGACGGGCCGCCCCTTCGTGGGCAAGGCGGGGCAG CTTCTAAACCGCATCCTGGAGGCGGCGGGGATCCCCAGGGAGGAGGTCTACATCACCAAC ATCGTCAAGTGCCGCCCCCCGCAAAACCGCGCCCCCCTTCCCGACGAGGCCAAGATCTGC ACGGACAAGTGGCTCCTCAAGCAGATTGAGCTCATCGCCCCCCAGATCATCGTCCCCTTG GGGGCGGTGGCCGCCGAGTTCTTCCTGGGGGAGAAGGTCTCCATCACCAAGGTCCGGGGG AAGTGGTACGAGTGGCACGGGATCAAGGTCTTCCCCATGTTCCACCCCGCCTACCTCCTC AGGAACCCGAGCCGGGCCCCGGGAAGCCCCAAGCACCTCACCTGGCTGGACATCCAAGAG GTCAAGCGGGCCCTGGACGCCCTCCCTCCCAAGGAGCGGCGCCCGGTGAAGGCGGTGAGC CAGGAGCCCCTCTTCTAA PF03167 UDG BE0003081 Pyrimidine-nucleoside phosphorylase Geobacillus stearothermophilus unknown Pyrimidine-nucleoside phosphorylase Involved in transferase activity, transferring glycosyl groups A pyrimidine nucleoside + phosphate = a pyrimidine base + alpha-D-ribose 1-phosphate pdp None 5.04 46333.0 Geobacillus stearothermophilus GenBank Gene Database D87961 UniProtKB P77836 UniProt Accession PDP_GEOSE EC 2.4.2.2 PYNP >Pyrimidine-nucleoside phosphorylase MRMVDLIEKKRDGHALTKEEIQFIIEGYTKGDIPDYQMSALAMAIFFRGMNEEETAELTM AMVHSGDTIDLSRIEGIKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGT IDKLESVPGFHVEITNDEFIDLVNKNKIAVVGQSGNLTPADKKLYALRDVTATVNSIPLI ASSIMSKKIAAGADAIVLDVKTGVGAFMKDLNDAKALAKAMVDIGNRVGRKTMAIISDMS QPLGYAIGNALEVKEAIDTLKGEGPEDFQELCLVLGSHMVYLAEKASSLEEARHMLEKAM KDGSALQTFKTFLAAQGGDASVVDDPSKLPQAKYIIELEAKEDGYVSEIVADAVGTAAMW LGAGRATKESTIDLAVGLVLRKKVGDAVKKGESLVTIYSNREQVDDVKQKLYENIRISAT PVQAPTLIYDKIS >1302 bp ATGAGAATGGTCGATTTAATTGAGAAAAAACGTGATGGTCATGCGTTAACGAAAGAAGAA ATTCAGTTTATTATTGAAGGTTACACAAAAGGCGATATTCCTGATTATCAAATGAGCGCA TTAGCGATGGCGATTTTTTTCCGCGGCATGAATGAAGAAGAGACAGCGGAATTGACGATG GCGATGGTGCATTCAGGCGATACGATCGACCTTTCGCGAATTGAAGGAATTAAAGTAGAC AAACATTCAACGGGCGGAGTGGGCGATACAACAACGTTAGTGCTTGGCCCTCTTGTCGCC TCCGTCGGTGTTCCGGTTGCGAAAATGTCTGGGCGCGGCCTTGGACATACGGGTGGAACG ATCGACAAACTAGAATCGGTGCCAGGTTTTCACGTTGAAATTACGAACGATGAATTTATC GATCTTGTCAATAAAAATAAAATTGCCGTTGTCGGTCAGTCTGGTAATTTGACGCCAGCG GACAAAAAGTTGTATGCGCTTCGTGATGTGACGGCAACGGTCAATAGCATTCCGTTAATT GCCTCATCGATTATGAGCAAAAAAATTGCCGCAGGGGCAGATGCGATCGTACTTGACGTA AAAACAGGTGTGGGCGCGTTTATGAAAGATTTAAACGATGCAAAAGCATTAGCGAAAGCG ATGGTCGATATCGGAAATCGGGTTGGGCGTAAAACGATGGCAATTATTTCTGATATGAGC CAGCCGCTTGGTTATGCCATTGGAAATGCGCTTGAAGTGAAAGAAGCGATTGATACGTTA AAAGGAGAAGGTCCAGAAGATTTCCAAGAGCTGTGCTTAGTGCTTGGTAGCCACATGGTA TATTTAGCGGAAAAAGCATCTTCGCTTGAAGAAGCTCGTCATATGTTAGAAAAAGCGATG AAAGACGGTTCAGCCCTTCAAACATTTAAAACGTTCTTAGCTGCGCAAGGTGGCGATGCA TCTGTTGTCGATGACCCAAGCAAATTGCCGCAAGCAAAATATATTATTGAACTAGAAGCG AAAGAAGATGGATACGTATCCGAAATTGTCGCGGATGCGGTCGGAACGGCGGCGATGTGG CTTGGTGCAGGGCGAGCGACGAAAGAATCAACGATCGATTTAGCTGTCGGTCTCGTGCTT CGCAAAAAAGTCGGCGATGCGGTGAAAAAAGGTGAATCGCTCGTTACAATTTACAGCAAC CGTGAACAAGTGGATGATGTAAAACAAAAACTATATGAAAACATTCGTATTTCAGCAACA CCTGTTCAAGCTCCAACATTAATTTACGATAAAATTTCGTAA PF02885 Glycos_trans_3N PF00591 Glycos_transf_3 PF07831 PYNP_C function transferase activity function transferase activity, transferring glycosyl groups function catalytic activity process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process nucleobase metabolism process pyrimidine base metabolism process physiological process "

owl:sameAs

?:Deoxythymidine

"Uracil"

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