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PredicateValue (sorted: default)
rdfs:label
"Z-Pro-Prolinal"
rdf:type
ns1:drugs
ns1:description
" experimental This compound belongs to the alpha amino acid amides. These are amide derivatives of alpha amino acids. Alpha Amino Acid Amides Organic Compounds Organic Acids and Derivatives Carboxylic Acids and Derivatives Amino Acids, Peptides, and Analogues Benzyloxycarbonyls Benzylethers Pyrrolidinecarboxamides Pyrrolidine Carboxylic Acids Tertiary Carboxylic Acid Amides Tertiary Amines Carbamic Acids and Derivatives Ethers Enolates Carboxylic Acids Polyamines Aldehydes benzyloxycarbonyl benzylether pyrrolidine carboxylic acid pyrrolidine carboxylic acid or derivative pyrrolidine-2-carboxamide benzene tertiary carboxylic acid amide pyrrolidine carbamic acid derivative carboxamide group tertiary amine polyamine enolate ether carboxylic acid amine organonitrogen compound aldehyde logP 1.25 ALOGPS logS -2.3 ALOGPS Water Solubility 1.53e+00 g/l ALOGPS logP 1.43 ChemAxon IUPAC Name benzyl (2S)-2-{[(2S)-2-formylpyrrolidin-1-yl]carbonyl}pyrrolidine-1-carboxylate ChemAxon Traditional IUPAC Name Z-pro-prolinal ChemAxon Molecular Weight 330.3783 ChemAxon Monoisotopic Weight 330.157957202 ChemAxon SMILES [H][C@]1(CCCN1C(=O)[C@]1([H])CCCN1C(=O)OCC1=CC=CC=C1)C=O ChemAxon Molecular Formula C18H22N2O4 ChemAxon InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1 ChemAxon InChIKey InChIKey=ORZXYSPOAVJYRU-HOTGVXAUSA-N ChemAxon Polar Surface Area (PSA) 66.92 ChemAxon Refractivity 87.93 ChemAxon Polarizability 34.45 ChemAxon Rotatable Bond Count 5 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 0 ChemAxon pKa (strongest acidic) 15.37 ChemAxon pKa (strongest basic) -4 ChemAxon Physiological Charge 0 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon PubChem Compound 122623 PubChem Substance 46507956 ChemSpider 109328 PDB ZPR BE0002148 Prolyl endopeptidase Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Prolyl endopeptidase Amino acid transport and metabolism Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long PREP 6q22 Cytoplasm None 5.58 80764.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:9358 GenAtlas PREP GeneCards PREP GenBank Gene Database X74496 GenBank Protein Database 558596 UniProtKB P48147 UniProt Accession PPCE_HUMAN EC 3.4.21.26 PE Post-proline cleaving enzyme >Prolyl endopeptidase MLSFQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF TFKTNRQSPNYRVINIDFWDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP >2133 bp ATGCTGTCCTTCCAGTACCCCGACGTGTACCGCGACGAGACCGCCGTACAGGATTATCAT GGTCATAAAATTTGTGACCCTTACGCCTGGCTTGAAGACCCCGACAGTGAACAGACTAAG GCCTTTGTGGAGGCCCAGAATAAGATTACTGTGCCATTTCTTGAGCAGTGTCCCATCAGA GGTTTATACAAAGAGAGAATGACTGAACTATATGATTATCCCAAGTATAGTTGCCACTTC AAGAAAGGAAAACGGTATTTTTATTTTTACAATACAGGTTTGCAGAACCAGCGAGTATTA TATGTACAGGATTCCTTAGAGGGGGAGGCCAGAGTGTTCCTGGACCCCAACATACTGTCT GACGATGGCACAGTGGCACTCCGAGGTTATGCGTTCAGCGAAGATGGTGAATATTTTGCC TATGGTCTGAGTGCCAGTGGCTCAGACTGGGTGACAATCAAGTTCATGAAAGTTGATGGT GCCAAAGAGCTTCCAGATGTGCTTGAAAGAGTCAAGTTCAGCTGTATGGCCTGGACCCAT GATGGGAAGGGAATGTTCTACAACTCATACCCTCAACAGGATGGAAAAAGTGATGGCACA GAGACATCTACCAATCTCCACCAAAAGCTCTACTACCATGTCTTGGGAACCGATCAGTCA GAAGATATTTTGTGTGCTGAGTTTCCTGATGAACCTAAATGGATGGGTGGAGCTGAGTTA TCTGATGATGGCCGCTATGTCTTGTTATCAATAAGGGAAGGATGTGATCCAGTAAACCGA CTCTGGTACTGTGACCTACAGCAGGAATCCAGTGGCATCGCGGGAATCCTGAAGTGGGTA AAACTGATTGACAACTTTGAAGGGGAATATGACTACGTGACCAATGAGGGGACGGTGTTC ACATTCAAGACGAATCGCCAGTCTCCCAACTATCGCGTGATCAACATTGACTTCTGGGAT CCTGAAGAGTCTAAGTGGAAAGTACTTGTTCCTGAGCATGAGAAAGATGTCTTAGAATGG ATAGCTTGTGTCAGGTCCAACTTCTTGGTCTTATGCTACCTCCATGACGTCAAGAACATT CTGCAGCTCCATGACCTGACTACTGGTGCTCTCCTTAAGACCTTCCCGCTCGATGTCGGC AGCATTGTAGGGTACAGCGGTCAGAAGAAGGACACTGAAATCTTCTATCAGTTTACTTCC TTTTTATCTCCAGGTATCATTTATCACTGTGATCTTACCAAAGAGGAGCTGGAGCCAAGA GTTTTCCGAGAGGTGACCGTAAAAGGAATTGATGCTTCTGATTACCAGACAGTCCAGATT TTCTACCCTAGCAAGGATGGTACGAAGATTCCAATGTTCATTGTGCATAAAAAAGGCATA AAATTGGATGGCTCTCATCCAGCTTTCTTATATGGCTATGGCGGCTTCAACATATCCATC ACACCCAACTACAGTGTTTCCAGGCTTATTTTTGTGAGACACATGGGTGGTATCCTGGCA GTGGCCAACATCAGAGGAGGTGGCGAATATGGAGAGACGTGGCATAAAGGTGGTATCTTG GCCAACAAACAAAACTGCTTTGATGACTTTCAGTGTGCTGCTGAGTATCTGATCAAGGAA GGTTACACATCTCCCAAGAGGCTGACTATTAATGGAGGTTCAAATGGAGGCCTCTTAGTG GCTGCTTGTGCAAATCAGAGACCTGACCTCTTTGGTTGTGTTATTGCCCAAGTTGGAGTA ATGGACATGCTGAAGTTTCATAAATATACCATCGGCCATGCTTGGACCACTGATTATGGG TGCTCGGACAGCAAACAACACTTTGAATGGCTTGTCAAATACTCTCCATTGCATAATGTG AAGTTACCAGAAGCAGATGACATCCAGTACCCGTCCATGCTGCTCCTCACTGCTGACCAT GATGACCGCGTGGTCCCGCTTCACTCCCTGAAGTTCATTGCCACCCTTCAGTACATCGTG GGCCGCAGCAGGAAGCAAAGCAACCCCCTGCTTATCCACGTGGACACCAAGGCGGGCCAC GGGGCGGGGAAGCCCACAGCCAAAGTGATAGAGGAAGTCTCAGACATGTTTGCGTTCATC GCGCGGTGCCTGAATGTCGACTGGATTCCATAA PF00326 Peptidase_S9 PF02897 Peptidase_S9_N function prolyl oligopeptidase activity function hydrolase activity function peptidase activity function endopeptidase activity function serine-type endopeptidase activity function serine-type peptidase activity function catalytic activity process metabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism process proteolysis process physiological process BE0004419 Prolyl endopeptidase Aeromonas punctata # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Prolyl endopeptidase Amino acid transport and metabolism Cytoplasmic None 6.03 76635.9 Aeromonas punctata GenBank Gene Database AF143951 GenBank Protein Database 4973227 UniProtKB Q9X6R4 UniProt Accession Q9X6R4_AERPU >Prolyl endopeptidase MSGKARLHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYLAQIP YRAAIKEKLAASWNYAKEGAPFREGRYHYFFKNDGLQNQNVLWRQKEGKPAEVFLDPNTL SPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHLMDVESKQPLETPLKDVKFSGISWL GNEGFFYSSYDKPDGSELSARTDQHKVYFHRLGTAQEDDRLVFGAIPAQHHRYVGATVTE DDRFLLISAANSTSGNRLYVKDLSQENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAP NRRLVTVDAANPGPAHWRDLIPERHRVLTVHSGTAYLFAEYMVDATAPVEQFDYEGKRVR EVALPGLGSVSGFNGKHDDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAPFKPEDY VSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVSLTPSFSVSVANWLDLG GVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNG GLLVGAVMTQRPDLMRVALPAVGVLDMLRYHTFTAGAGWAYDYGTSADSEAMFDYLKGYS PLHNVRPGVSYPSTMVTTADHDDRVVPAHSFKFAATLQADNAGPHPQLIRIETNAGHGAG TPVAKLIEQSADIYAFTLYEMGYRELPRQP >2073 bp ATGTCAGGGAAAGCGCGCCTTCACTACCCCGTCACCCGCCAGGGTGAGCAGGTGGATCAC TACTTCGGCCAGGCCGTGGCCGACCCCTATCGCTGGCTGGAGGATGATCGCAGCCCCGAG ACCGAGGCCTGGGTCAAGGCCCAGAATGCCGTGACCCAGGACTACCTGGCACAGATCCCG TATCGCGCTGCCATCAAGGAGAAGCTGGCCGCCTCCTGGAACTACGCCAAGGAGGGGGCG CCGTTTCGCGAGGGGCGCTACCACTACTTCTTCAAGAACGACGGCCTGCAGAACCAGAAC GTGCTGTGGCGCCAGAAGGAGGGCAAACCGGCGGAGGTGTTCCTAGATCCCAATACCCTC AGCCCCGACGGCACCACGGCGCTGGATCAGCTGAGCTTCTCCCGCGATGGCCGCATCCTG GCCTACTCGCTGTCGCTGGCGGGTAGCGACTGGCGCGAGATCCACCTGATGGACGTGGAG AGCAAGCAGCCGCTGGAGACCCCTCTCAAGGACGTGAAATTCAGCGGCATCAGCTGGCTC GGCAACGAGGGCTTCTTCTACTCGAGCTACGACAAGCCCGATGGCAGCGAGCTGTCGGCC AGGACTGATCAGCACAAGGTCTATTTCCACCGGCTCGGCACGGCGCAGGAGGATGACCGG CTGGTGTTCGGCGCCATCCCGGCCCAGCACCACCGCTACGTGGGGGCGACCGTCACCGAA GATGACCGCTTCCTGCTCATCTCGGCGGCGAACTCCACCTCCGGCAACCGCCTCTATGTG AAGGATCTGAGCCAGGAGAACGCGCCGCTGCTGACGGTGCAGGGGGATCTGGACGCGGAC GTGAGCCTGGTGGACAACAAGGGCAGCACCCTATACCTGCTGACCAACCGGGACGCCCCC AACCGCCGGCTGGTGACGGTGGATGCCGCCAACCCGGGGCCGGCCCACTGGCGCGACCTT ATCCCCGAGCGTCACAGGGTGCTGACGGTGCACAGCGGCACGGCCTATCTGTTCGCCGAG TACATGGTGGATGCCACCGCCCCGGTCGAGCAGTTCGACTACGAGGGCAAGCGGGTGCGC GAGGTGGCGCTGCCCGGCCTTGGCAGCGTCAGCGGCTTCAACGGCAAGCACGACGACCCC GCCCTCTACTTCGGCTTCGAGAACTATGCCCAGCCGCCCACTCTCTATCGGTTCGAGCCA AAGAGCGGCGCCATCAGCCTCTATCGCGCCTCGGCGGCGCCGTTCAAGCCGGAGGATTAC GTCTCCGAGCAGCGCTTCTACCAGAGCAAGGACGGCACCCGGGTGCCGCTCATCATCAGC TACCGCAAGGGGCTGAAACTCGATGGCAGCAACCCGACCATCCTCTACGGCTATGGCGGT TTTGACGTGAGCCTTACCCCGAGCTTCAGCGTATCGGTGGCCAACTGGCTGGATCTGGGG GGCGTCTATGCGGTGGCCAACCTGCGTGGGGGCGGCGAGTACGGCCAGGCCTGGCACCTG GCGGGCACCCAGCAGAACAAACAGAACGTGTTCGACGACTTCATCGCGGCGGCCGAGTAC CTCAAGGCCGAGGGCTACACCCGCACCGATCGGCTGGCGATCCGCGGTGGCTCCAACGGC GGTCTGCTGGTGGGGGCCGTGATGACCCAGCGGCCGGATCTGATGCGGGTCGCCCTGCCA GCGGTGGGGGTGCTCGACATGCTGCGCTACCACACCTTCACCGCCGGGGCGGGCTGGGCC TATGACTACGGCACCAGTGCCGACAGCGAGGCGATGTTCGACTACCTGAAGGGCTACTCG CCGCTGCACAACGTCCGACCCGGGGTCAGCTACCCCTCGACTATGGTGACCACGGCGGAT CACGACGATCGGGTGGTACCGGCTCACTCCTTCAAGTTTGCCGCCACCCTGCAGGCCGAC AATGCGGGCCCCCATCCCCAGCTCATCCGCATCGAGACCAATGCCGGGCACGGGGCGGGT ACGCCGGTGGCGAAGCTGATTGAGCAGAGTGCGGACATCTATGCCTTCACCCTGTACGAG ATGGGCTACCGGGAGCTGCCGCGTCAGCCTTGA PF00326 Peptidase_S9 PF02897 Peptidase_S9_N function prolyl oligopeptidase activity function hydrolase activity function peptidase activity function endopeptidase activity function serine-type endopeptidase activity function serine-type peptidase activity function catalytic activity process metabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism process proteolysis process physiological process "
owl:sameAs
?:EXPT03293

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