Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03800"
Predicate | Value (sorted: default) |
---|---|
rdfs:label |
"2'-deoxyuridylic acid"
|
rdf:type | |
ns1:description |
"
experimental
This compound belongs to the pyrimidine 2'-deoxyribonucleoside monophosphates. These are pyrimidine nucleotides with a monophosphate group linked to the ribose moiety lacking an hydroxyl group at position 2.
Pyrimidine 2'-deoxyribonucleoside Monophosphates
Organic Compounds
Organooxygen Compounds
Carbohydrates and Carbohydrate Conjugates
Glycosyl Compounds
Pentoses
Pyrimidones
Hydropyrimidines
Organic Phosphoric Acids
Organophosphate Esters
Tetrahydrofurans
Oxolanes
Secondary Alcohols
Polyamines
Ethers
pentose monosaccharide
pyrimidone
phosphoric acid ester
organic phosphate
hydropyrimidine
monosaccharide
pyrimidine
tetrahydrofuran
oxolane
secondary alcohol
ether
polyamine
alcohol
organonitrogen compound
amine
dUMP
logP
-1.4
ALOGPS
logS
-1.6
ALOGPS
Water Solubility
7.97e+00 g/l
ALOGPS
logP
-1.6
ChemAxon
IUPAC Name
{[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
ChemAxon
Traditional IUPAC Name
[(2R,3S,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxyphosphonic acid
ChemAxon
Molecular Weight
308.1819
ChemAxon
Monoisotopic Weight
308.040951914
ChemAxon
SMILES
O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O
ChemAxon
Molecular Formula
C9H13N2O8P
ChemAxon
InChI
InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
ChemAxon
InChIKey
InChIKey=JSRLJPSBLDHEIO-SHYZEUOFSA-N
ChemAxon
Polar Surface Area (PSA)
145.63
ChemAxon
Refractivity
61.93
ChemAxon
Polarizability
25.86
ChemAxon
Rotatable Bond Count
4
ChemAxon
H Bond Acceptor Count
7
ChemAxon
H Bond Donor Count
4
ChemAxon
pKa (strongest acidic)
1.23
ChemAxon
pKa (strongest basic)
-3.2
ChemAxon
Physiological Charge
-2
ChemAxon
Number of Rings
2
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
PubChem Compound
65063
PubChem Substance
46506977
PDB
UMP
BE0003128
Thymidylate synthase
Pneumocystis carinii
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidylate synthase
Involved in thymidylate synthase activity
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
THYA
None
6.58
34363.0
Pneumocystis carinii
GenBank Gene Database
M25415
UniProtKB
P13100
UniProt Accession
TYSY_PNECA
EC 2.1.1.45
TS
TSase
>Thymidylate synthase
MVNAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKFSLRNKTFPLLTTKRVFIR
GVIEELLWFIRGETDSLKLREKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHF
GAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMALPPCHMFCQFY
VHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCH
IYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYETIKMKMSI
>894 bp
ATGGTAAACGCAGAAGAACAACAATATCTCAACTTAGTACAATATATTATTAACCATGGG
GAAGACCGCCCTGATAGGACAGGGACAGGGACTTTATCTGTTTTTGCACCGTCTCCGCTA
AAGTTTTCTCTTCGAAATAAAACATTTCCACTCTTAACAACCAAGCGAGTTTTTATACGT
GGAGTAATTGAAGAATTGCTTTGGTTTATTCGTGGAGAAACAGATTCTTTAAAACTTAGA
GAGAAAAATATTCATATATGGGATGCAAATGGATCACGAGAGTACCTTGACTCAATTGGA
TTGACTAAACGCCAGGAAGGTGATCTTGGTCCCATTTATGGGTTTCAATGGAGGCATTTT
GGAGCAGAATATATTGATTGCAAAACCAATTATATTGGACAAGGTGTTGATCAATTAGCC
AATATTATCCAAAAAATACGAACATCACCATATGATCGTCGACTCATACTTTCAGCATGG
AATCCTGCAGATTTAGAAAAAATGGCATTACCTCCGTGCCATATGTTTTGTCAGTTTTAT
GTTCATATACCATCGAATAACCACCGACCTGAACTCTCATGTCAATTATACCAACGTTCT
TGTGACATGGGGCTAGGTGTTCCCTTTAATATTGCATCGTATGCTCTACTAACATGCATG
ATTGCACATGTTTGTGATCTTGATCCAGGTGATTTTATCCATGTCATGGGTGATTGTCAT
ATTTATAAGGATCATATTGAAGCACTACAACAACAACTTACACGCTCCCCACGACCTTTT
CCCACTCTTTCTTTAAATCGCTCAATCACTGATATTGAAGATTTTACATTAGATGATTTT
AATATTCAAAACTATCATCCATATGAAACTATAAAAATGAAAATGTCCATTTGA
PF00303
Thymidylat_synt
function
transferase activity
function
transferase activity, transferring one-carbon groups
function
methyltransferase activity
function
5,10-methylenetetrahydrofolate-dependent methyltransferase activity
function
thymidylate synthase activity
function
catalytic activity
process
pyrimidine nucleotide biosynthesis
process
metabolism
process
pyrimidine nucleoside monophosphate biosynthesis
process
cellular metabolism
process
pyrimidine deoxyribonucleoside monophosphate biosynthesis
process
dTMP biosynthesis
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
physiological process
process
pyrimidine nucleotide metabolism
BE0001364
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Nucleotide transport and metabolism
This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
dut
Cytoplasmic
None
4.87
16156.0
Escherichia coli (strain K12)
GenBank Gene Database
X01714
GenBank Protein Database
41297
UniProtKB
P06968
UniProt Accession
DUT_ECOLI
dUTP pyrophosphatase
dUTPase
EC 3.6.1.23
>Deoxyuridine 5'-triphosphate nucleotidohydrolase
MKKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLNDAVELAPGDTTLVPTGLAIHIAD
PSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQMI
FVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ
>456 bp
ATGAAAAAAATCGACGTTAAGATTCTGGACCCGCGCGTTGGGAAGGAATTTCCGCTCCCG
ACTTATGCCACCTCTGGCTCTGCCGGACTTGACCTGCGTGCCTGTCTCAACGACGCCGTA
GAACTGGCTCCGGGTGACACTACGCTGGTTCCGACCGGGCTGGCGATTCATATTGCCGAT
CCTTCACTGGCGGCAATGATGCTGCCGCGCTCCGGATTGGGACATAAGCACGGTATCGTG
CTTGGTAACCTGGTAGGATTGATCGATTCTGACTATCAGGGCCAGTTGATGATTTCCGTG
TGGAACCGTGGTCAGGACAGCTTCACCATTCAACCTGGCGAACGCATCGCCCAGATGATT
TTTGTTCCGGTAGTACAGGCTGAATTTAATCTGGTGGAAGATTTCGACGCCACCGACCGC
GGTGAAGGCGGCTTTGGTCACTCTGGTCGTCAGTAA
PF00692
dUTPase
function
catalytic activity
function
hydrolase activity
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
pyrimidine nucleotide metabolism
process
pyrimidine nucleoside triphosphate metabolism
process
pyrimidine deoxyribonucleoside triphosphate metabolism
process
dUTP metabolism
process
physiological process
process
metabolism
process
cellular metabolism
BE0001501
Thymidylate synthase
Lactobacillus casei
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidylate synthase
Nucleotide transport and metabolism
Provides the sole de novo source of dTMP for DNA biosynthesis
thyA
Cytoplasm
None
6.28
36580.0
Lactobacillus casei
GenBank Gene Database
M19653
GenBank Protein Database
149601
UniProtKB
P00469
UniProt Accession
TYSY_LACCA
EC 2.1.1.45
TS
TSase
>Thymidylate synthase
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
>990 bp
ATGTGTCGAGTAGTGAACGGTAAAGGAGCAGAGCAGACAATGTTAGAACAGCCATATCTT
GATCTTGCAAAAAAAGTTCTGGATGAAGGCCATTTCAAGCCTGATCGGACCCATACAGGA
ACTTACAGTATTTTCGGCCACCAAATGCGTTTCGACCTTAGCAAGGGCTTTCCATTACTG
ACGACCAAAAAAGTACCATTCGGCCTTATTAAGAGTGAGTTGTTGTGGTTTTTACACGGT
GATACCAACATTCGGTTCTTACTCCAACACAGGAATCACATTTGGGATGAGTGGGCGTTT
GAAAAATGGGTGAAGAGTGATGAATATCACGGCCCGGACATGACTGATTTTGGGCATCGC
AGCCAAAAGGATCCGGAATTCGCGGCAGTTTATCATGAAGAAATGGCTAAATTCGATGAC
CGGGTGCTTCATGATGATGCTTTTGCAGCCAAATATGGTGATCTTGGCTTGGTTTATGGA
TCCCAATGGCGGGCCTGGCATACGAGCAAGGGTGACACGATCGACCAGTTGGGGGACGTT
ATTGAGCAAATCAAAACGCATCCCTATTCACGACGGCTCATCGTGTCGGCGTGGAATCCG
GAAGATGTCCCGACAATGGCGCTACCGCCTTGTCACACGCTCTATCAGTTTTATGTCAAT
GATGGCAAGCTGTCTTTGCAGTTGTACCAACGTTCGGCTGACATTTTTCTTGGCGTCCCG
TTTAATATCGCGTCCTATGCGTTGTTAACGCATCTGGTCGCGCATGAATGTGGCCTTGAA
GTTGGCGAATTCATTCATACATTCGGCGATGCGCATCTTTACGTCAATCATCTTGACCAA
ATTAAAGAGCAGCTCAGTCGCACGCCGCGGCCGGCACCGACTTTACAGTTGAATCCGGAT
AAACATGATATTTTCGACTTTGACATGAAGGATATTAAGTTGCTTAATTACGATCCTTAT
CCGGCCATTAAGGCACCGGTTGCCGTTTAA
PF00303
Thymidylat_synt
function
transferase activity, transferring one-carbon groups
function
methyltransferase activity
function
5,10-methylenetetrahydrofolate-dependent methyltransferase activity
function
thymidylate synthase activity
function
catalytic activity
function
transferase activity
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
physiological process
process
pyrimidine nucleotide metabolism
process
pyrimidine nucleotide biosynthesis
process
metabolism
process
pyrimidine nucleoside monophosphate biosynthesis
process
cellular metabolism
process
pyrimidine deoxyribonucleoside monophosphate biosynthesis
process
dTMP biosynthesis
BE0001438
Thymidylate synthase
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidylate synthase
Nucleotide transport and metabolism
Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation
thyA
Cytoplasm
None
5.94
30480.0
Escherichia coli (strain K12)
GenBank Gene Database
J01710
GenBank Protein Database
147987
UniProtKB
P0A884
UniProt Accession
TYSY_ECOLI
EC 2.1.1.45
TS
TSase
>Thymidylate synthase
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
>795 bp
ATGAAACAGTATTTAGAACTGATGCAAAAAGTGCTCGACGAAGGCACACAGAAAAACGAC
CGTACCGGAACCGGAACGCTTTCCATTTTTGGTCATCAGATGCGTTTTAACCTGCAAGAT
GGATTCCCGCTGGTGACAACTAAACGTTGCCACCTGCGTTCCATCATCCATGAACTGCTG
TGGTTTCTGCAGGGCGACACTAACATTGCTTATCTACACGAAAACAATGTCACCATCTGG
GACGAATGGGCCGATGAAAACGGCGACCTCGGGCCAGTGTATGGTAAACAGTGGCGCGCC
TGGCCAACGCCAGATGGTCGTCATATTGACCAGATCACTACGGTACTGAACCAGCTGAAA
AACGACCCGGATTCGCGCCGCATTATTGTTTCAGCGTGGAACGTAGGCGAACTGGATAAA
ATGGCGCTGGCACCGTGCCATGCATTCTTCCAGTTCTATGTGGCAGACGGCAAACTCTCT
TGCCAGCTTTATCAGCGCTCCTGTGACGTCTTCCTCGGCCTGCCGTTCAACATTGCCAGC
TACGCGTTATTGGTGCATATGATGGCGCAGCAGTGCGATCTGGAAGTGGGTGATTTTGTC
TGGACCGGTGGCGACACGCATCTGTACAGCAACCATATGGATCAAACTCATCTGCAATTA
AGCCGCGAACCGCGTCCGCTGCCGAAGTTGATTATCAAACGTAAACCCGAATCCATCTTC
GACTACCGTTTCGAAGACTTTGAGATTGAAGGCTACGATCCGCATCCGGGCATTAAAGCG
CCGGTGGCTATCTAA
PF00303
Thymidylat_synt
function
transferase activity
function
transferase activity, transferring one-carbon groups
function
methyltransferase activity
function
5,10-methylenetetrahydrofolate-dependent methyltransferase activity
function
thymidylate synthase activity
function
catalytic activity
process
metabolism
process
pyrimidine nucleoside monophosphate biosynthesis
process
cellular metabolism
process
pyrimidine deoxyribonucleoside monophosphate biosynthesis
process
dTMP biosynthesis
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
physiological process
process
pyrimidine nucleotide metabolism
process
pyrimidine nucleotide biosynthesis
BE0000324
Thymidylate synthase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Thymidylate synthase
Nucleotide transport and metabolism
TYMS
18p11.32
None
7.0
35585.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12441
GenAtlas
TYMS
GeneCards
TYMS
GenBank Gene Database
X02308
GenBank Protein Database
37479
UniProtKB
P04818
UniProt Accession
TYSY_HUMAN
EC 2.1.1.45
TS
TSase
>Thymidylate synthase
PVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGM
QARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSL
GFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCA
WNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHIT
GLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGY
NPHPTIKMEMAV
>942 bp
ATGCCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCACAGGAGCGG
GACGCCGAGCCGCGTCCGCCGCACGGGGAGCTGCAGTACCTGGGGCAGATCCAACACATC
CTCCGCTGCGGCGTCAGGAAGGACGACCGCACGGGCACCGGCACCCTGTCGGTATTCGGC
ATGCAGGCGCGCTACAGCCTGAGAGATGAATTCCCTCTGCTGACAACCAAACGTGTGTTC
TGGAAGGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGGGATCCACAAATGCTAAAGAG
CTGTCTTCCAAGGGAGTGAAAATCTGGGATGCCAATGGATCCCGAGACTTTTTGGACAGC
CTGGGATTCTCCACCAGAGAAGAAGGGGACTTGGGCCCAGTTTATGGCTTCCAGTGGAGG
CATTTTGGGGCAGAATACAGAGATATGGAATCAGATTATTCAGGACAGGGAGTTGACCAA
CTGCAAAGAGTGATTGACACCATCAAAACCAACCCTGACGACAGAAGAATCATCATGTGC
GCTTGGAATCCAAGAGATCTTCCTCTGATGGCGCTGCCTCCATGCCATGCCCTCTGCCAG
TTCTATGTGGTGAACAGTGAGCTGTCCTGCCAGCTGTACCAGAGATCGGGAGACATGGGC
CTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCACGTACATGATTGCGCACATC
ACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGATGCACATATTTACCTGAAT
CACATCGAGCCACTGAAAATTCAGCTTCAGCGAGAACCCAGACCTTTCCCAAAGCTCAGG
ATTCTTCGAAAAGTTGAGAAAATTGATGACTTCAAAGCTGAAGACTTTCAGATTGAAGGG
TACAATCCGCATCCAACTATTAAAATGGAAATGGCTGTTTAG
PF00303
Thymidylat_synt
function
transferase activity
function
transferase activity, transferring one-carbon groups
function
methyltransferase activity
function
5,10-methylenetetrahydrofolate-dependent methyltransferase activity
function
thymidylate synthase activity
function
catalytic activity
process
pyrimidine nucleotide biosynthesis
process
metabolism
process
pyrimidine nucleoside monophosphate biosynthesis
process
cellular metabolism
process
pyrimidine deoxyribonucleoside monophosphate biosynthesis
process
dTMP biosynthesis
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
physiological process
process
pyrimidine nucleotide metabolism
BE0001409
Thymidylate synthase ThyX
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidylate synthase ThyX
Nucleotide transport and metabolism
Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate
thyX
None
8.38
26004.0
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
GenBank Gene Database
AE000512
GenBank Protein Database
4980954
UniProtKB
Q9WYT0
UniProt Accession
THYX_THEMA
EC 2.1.1.148
TS
TSase
>Thymidylate synthase thyX
MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHI
VFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTE
KISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQ
WEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV
>663 bp
TCATACCTGTACCTCCTTCAGGATATCTCCTTTATAAGCATACTTAAGAAATGCCTCAAA
AGTCCAGGGACACTTCTCTTTGAAAATTCTCGCGATTGCCAGAGCGTACTGTTGAATTTC
CCACTGAGCGTGAGAATCTGCCCTCAGGTTCAAAAAGTTCATGAGACTTCTTGCGTTCAC
AGTCCAGAAAAACCTCGTGTACAGATTCAAAGGGAGCACTATCCTTGCCACTTCTCGAGG
AACACCGCTTTCTATCAACTCCAGATACGTTCGATACGCTTTATCGACTATTTCTGAGAT
CTTCTCCGTCACCCGTTCGGGAGGGATGGTCGTTTTGTACCCTTCCAGGCGTTCGGGAGA
GGGAATGTAGAATTCGTAGGAGAGCTTCGAGTATCTGCCGCTCAGTTCGTTGTAAGAAGC
GATCCTGTGTCTGAACCACTGCCTCGCCACGAATATAGGGGCTTTCACGTGGAAAGTGAA
GACAATATGTTCGAAAGGTGTCTCGTGACCGTGTTTCATGAGATATTCGATGAGATGTCT
ATCCCTTTCTTCGTCTTTCAAACCCATATCGAAAGAAACGCGGGCAGCCCGTACAGCGGA
GAGGTCGTTTCCCATCACATCCACAAGTTCAACGAATCCTTTGTCCAAGATATCGATCTT
CAT
PF02511
Thy1
BE0001400
Pol polyprotein
FIV
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Pol polyprotein
Nucleotide transport and metabolism
During replicative cycle of retroviruses, the reverse- transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase
pol
Cytoplasmic
None
8.06
127496.0
FIV
GenBank Gene Database
M25381
GenBank Protein Database
323935
UniProtKB
P16088
UniProt Accession
POL_FIVPE
Deoxyuridine 5'-triphosphate nucleotidohydrolase
dUTPase
EC 2.7.7.49
EC 3.1.26.4
EC 3.4.23.-
EC 3.6.1.23
IN]
Integrase
Pol polyprotein [Contains: Protease
Retropepsin
Reverse transcriptase/ribonuclease H
RT
>Pol polyprotein [Contains: Protease
KEFGKLEGGASCSPSESNAASSNAICTSNGGETIGFVNYNKVGTTTTLEKRPEILIFVNG
YPIKFLLDTGADITILNRRDFQVKNSIENGRQNMIGVGGGKRGTNYINVHLEIRDENYKT
QCIFGNVCVLEDNSLIQPLLGRDNMIKFNIRLVMAQISDKIPVVKVKMKDPNKGPQIKQW
PLTNEKIEALTEIVERLEKEGKVKRADSNNPWNTPVFAIKKKSGKWRMLIDFRELNKLTE
KGAEVQLGLPHPAGLQIKKQVTVLDIGDAYFTIPLDPDYAPYTAFTLPRKNNAGPGRRFV
WCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLSKKEHKEKVEEL
RKLLLWWGFETPEDKLQEEPPYTWMGYELHPLTWTIQQKQLDIPEQPTLNELQKLAGKIN
WASQAIPDLSIKALTNMMRGNQNLNSTRQWTKEARLEVQKAKKAIEEQVQLGYYDPSKEL
YAKLSLVGPHQISYQVYQKDPEKILWYGKMSRQKKKAENTCDIALRACYKIREESIIRIG
KEPRYEIPTSREAWESNLINSPYLKAPPPEVEYIHAALNIKRALSMIKDAPIPGAETWYI
DGGRKLGKAAKAAYWTDTGKWRVMDLEGSNQKAEIQALLLALKAGSEEMNIITDSQYVIN
IILQQPDMMEGIWQEVLEELEKKTAIFIDWVPGHKGIPGNEEVDKLCQTMMIIEGDGILD
KRSEDAGYDLLAAKEIHLLPGEVKVIPTGVKLMLPKGYWGLIIGKSSIGSKGLDVLGGVI
DEGYRGEIGVIMINVSRKSITLMERQKIAQLIILPCKHEVLEQGKVVMDSERGDNGYGST
GVFSSWVDRIEEAEINHEKFHSDPQYLRTEFNLPKMVAEEIRRKCPVCRIIGEQVGGQLK
IGPGIWQMDCTHFDGKIILVGIHVESGYIWAQIISQETADCTVKAVLQLLSAHNVTELQT
DNGPNFKNQKMEGVLNYMGVKHKFGIPGNPQSQALVENVNHTLKVWIQKFLPETTSLDNA
LSLAVHSLNFKRRGRIGGMAPYELLAQQESLRIQDYFSAIPQKLQAQWIYYKDQKDKKWK
GPMRVEYWGQGSVLLKDEEKGYFLIPRRHIRRVPEPCALPEGDE
>2993 bp
GTGTCTTAGAAGATAACTCATTAATACAACCATTATTAGGGAGAGATAATATGATTAAAT
TCAATATTAGGTTAGTAATGGCTCAAATTTCTGATAAGATTCCAGTAGTAAAAGTAAAAA
TGAAGGATCCTAATAAAGGACCTCAAATAAAACAATGGCCATTAACAAATGAAAAAATTG
AAGCCTTAACAGAAATAGTAGAAAGACTAGAAAGAGAAGGGAAAGTAAAAAGAGCAGATC
CAAATAATCCATGGAATACACCAGTATTTGCTATAAAAAAGAAAAGTGGAAAATGGAGAA
TGCTCATAGATTTTAGAGAATTAAACAAACTAACTGAGAAAGGAGCAGAGGTCCAGTTGG
GACTACCTCATCCTGCTGGTTTACAAATAAAAAAACAAGTAACAGTATTAGATATAGGGG
ATGCATATTTCACCATTCCTCTTGATCCAGATTATGCTCCTTATACAGCATTTACTTTAC
CTAGAAAAAATAATGCGGGACCAGGAAGGAGATTTGTGTGGTGTAGTCTACCACAAGGCT
GGATTTTAAGTCCATTGATATATCAAAGTACATTAGATAATATAATACAACCTTTTATTA
GACAAAATCCTCAATTAGATATTTACCAATATATGGATGACATTTATATAGGATCAAATT
TAAGTAAAAAGGAGCATAAAGAAAAGGTAGAAGAATTAAGAAAATTACTATTATGGTGGG
GATTTGAAACTCCAGAAGATAAATTACAGGAAGAACCCCCATATACATGGATGGGTTATG
AATTACATCCATTAACATGGACAATACAACAGAAACAGTTAGACATTCCAGAACAGCCCA
CTCTAAATGAGTTGCAAAAATTAGCAGGAAAAATTAATTGGGCTAGCCAAGCTATTCCAG
ACTTGAGTATAAAAGCATTAACTAACATGATGAGAGGAAATCAAAACCTAAATTCAACAA
GACAATGGACTAAAGAAGCTCGACTGGAAGTACAAAAGGCAAAAAAGGCTATAGAAGAAC
AAGTACAACTAGGATACTATGACCCCAGTAAGGAGTTATATGCTAAATTAAGTTTGGTGG
GACCACATCAAATAAGTTATCAAGTATATCAGAAGGATCCAGAAAAGATACTATGGTATG
GAAAAATGAGTAGACAAAAGAAAAAGGCAGAAAATACATGTGATATAGCCTTAAGAGCAT
GCTATAAGATAAGAGAAGAGTCTATTATAAGAATAGGAAAAGAACCAAGATATGAAATAC
CTACTTCTAGAGAAGCCTGGGAATCAAATTTAATTAATTCACCATATCTTAAGGCCCCAC
CTCCTGAGGTAGAATATATCCATGCTGCTTTGAATATAAAGAGAGCGTTAAGTATGATAA
AAGATGCTCCAATACCAGGAGCAGAAACATGGTATATAGATGGAGGTAGAAAGCTAGGAA
AAGCAGCAAAAGCAGCCTATTGGACAGATACAGGAAAGTGGCAAGTGATGGAATTAGAAG
GCAGTAATCAGAAGGCAGAAATACAAGCATTATTATTGGCATTAAAAGCAGGATCAGAGG
AGATGAATATTATAACAGATTCACAATATGTTATAAATATTATTCTTCAACAACCAGATA
TGATGGAGGGAATCTGGCAAGAAGTTTTAGAAGAATTGGAGAAGAAAACAGCAATATTTA
TAGATTGGGTCCCAGGACATAAAGGTATTCCAGGAAATGAGGAAGTAGATAAGCTTTGTC
AAACAATGATGATAATAGAAGGGGATGGGATATTAGATAAAAGGTCAGAAGATGCAGGAT
ATGATTTATTAGCTGCAAAAGAAATACATTTATTGCCAGGAGAGGTAAAAGTAATACCAA
CAGGGGTAAAGCTAATGTTGCCTAAAGGATATTGGGGATTAATAATAGGAAAAAGCTCGA
TAGGGAGTAAAGGATTGGATGTATTAGGAGGGGTAATAGACGAAGGATATCGAGGTGAAA
TTGGAGTAATAATGATTAATGTATCAAGAAAATCAATCACCTTAATGGAACGACAAAAGA
TAGCACAATTAATAATATTGCCTTGTAAACATGAAGTATTAGAACAAGGAAAAGTAGTAA
TGGATTCAGAGAGAGGAGACAATGGTTATGGGTCAACAGGAGTATTCTCCTCTTGGGTTG
ACAGAATTGAGGAAGCAGAAATAAATCATGAAAAATTTCACTCAGATCCACAGTACTTAA
GGACTGAATTTAATTTACCTAAAATGGTAGCAGAAGAGATAAGACGAAAATGCCCAGTAT
GCAGAATCAGAGGAGAACAAGTGGGAGGACAATTGAAAATAGGGCCTGGTATCTGGCAAA
TGGATTGCACACACTTTGATGGCAAAATAATTCTTGTGGGTATACATGTGGAATCAGGAT
ATATATGGGCACAAATAATTTCTCAAGAAACTGCTGACTGTACAGTTAAAGCTGTCTTAC
AATTGTTGAGTGCTCATAATGTTACTGAATTACAAACAGATAATGGACCAAATTTTAAAA
ATCAAAAGATGGAAGGAGTACTCAATTACATGGGTGTGAAACATAAGTTTGGTATCCCAG
GGAACCCACAGTCACAAGCATTAGTTGAAAATGTAAATCATACATTAAAAGTTTGGATTC
GGAAATTTTTGCCTGAAACAACCTCCTTGGATAATGCCTTATCTCTCGCTGTACATAGTC
TCAATTTTAAAAGAAGAGGTAGGATAGGAGGGATGGCCCCTTATGAATTATTAGCACAAC
AAGAATCCTTAAGAATACAAGATTATTTTTCTGCAATACCACAAAAATTGCAAGCACAGT
GGATTTATTATAAAGATCAAAAAGATAAGAAATGGAAAGGACCAATGAGAGTAGAATACT
GGGGACAGGGATCAGTATTATTAAAGGATGAAGAGAAGGGATATTTTCTTATACCTAGGA
GACACATAAGGAGAGTTCCAGAACCCTGCGCTCTTCCTGAAGGGGATGAGTGA
PF00078
RVT_1
PF00552
Integrase
PF02022
Integrase_Zn
PF00075
RnaseH
PF00665
rve
PF00077
RVP
PF06815
RVT_connect
PF06817
RVT_thumb
PF00692
dUTPase
function
ion binding
function
aspartic-type endopeptidase activity
function
cation binding
function
nuclease activity
function
transition metal ion binding
function
peptidase activity
function
RNA-directed DNA polymerase activity
function
transferase activity
function
endopeptidase activity
function
binding
function
endonuclease activity
function
zinc ion binding
function
endoribonuclease activity
function
transferase activity, transferring phosphorus-containing groups
function
hydrolase activity, acting on ester bonds
function
catalytic activity
function
endoribonuclease activity, producing 5'-phosphomonoesters
function
nucleic acid binding
function
DNA binding
function
ribonuclease H activity
function
RNA binding
function
hydrolase activity
function
integrase activity
function
nucleotidyltransferase activity
process
macromolecule metabolism
process
DNA integration
process
pyrimidine nucleotide metabolism
process
DNA recombination
process
pyrimidine nucleoside triphosphate metabolism
process
protein metabolism
process
pyrimidine deoxyribonucleoside triphosphate metabolism
process
cellular protein metabolism
process
dUTP metabolism
process
proteolysis
process
physiological process
process
metabolism
process
DNA replication
process
cellular metabolism
process
RNA-dependent DNA replication
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
DNA metabolism
process
nucleotide metabolism
BE0001318
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Mycobacterium tuberculosis
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Nucleotide transport and metabolism
This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
dut
Cytoplasmic
None
5.99
15803.0
Mycobacterium tuberculosis
GenBank Gene Database
BX842580
GenBank Protein Database
2181988
UniProtKB
P0A552
UniProt Accession
DUT_MYCTU
dUTP pyrophosphatase
dUTPase
EC 3.6.1.23
>Deoxyuridine 5'-triphosphate nucleotidohydrolase
MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGL
VHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVE
LVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL
>465 bp
TCACAAACTCGCATGTCCGCCGGAGGAACCGTGGCCACCGTCGCCGCGGGATGTCGAGGC
CAGCCCGGCCTCGTCGAACGACGAGACCTCGACCAGCTCGACCAACTCAACCCGTTGCAC
TAGCAACTGGGCGATTCGGTCACCGCGATGTACCACGATGGGCGCGGCTGGGTCCAAGTT
GATCAGGGCCACCTTGATCTCCCCACGATAACCCGCGTCGATGGTGCCCGGACTGTTGAC
GATCGAAAGCCCCACCCGCGTGGCCAACCCGGAGCGCGGATGGACCAGCCCGACCATGCC
GAACGGGACGGCGACCGCAACACCCGTCCGTACCAGGGCGCGGCGCCCAGGTGCCAGCTC
GACGTCTTCGGCGCTGTAGAGATCAACGCCGGCGTCGCCGTCGTGAGCGCGGCTGGGCAG
CGGGAGCCCGGGGTCGAGGCGGACGATCGCCAGAGTGGTCGACAC
PF00692
dUTPase
function
hydrolase activity
function
catalytic activity
process
metabolism
process
cellular metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
pyrimidine nucleotide metabolism
process
pyrimidine nucleoside triphosphate metabolism
process
pyrimidine deoxyribonucleoside triphosphate metabolism
process
dUTP metabolism
process
physiological process
"
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owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt
The resource does not appear as an object