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PredicateValue (sorted: none)
ns1:description
" experimental This compound belongs to the hexose phosphates. These are carbohydrate derivatives containing an hexose substituted by one or more phosphate groups. Hexose Phosphates Organic Compounds Organooxygen Compounds Carbohydrates and Carbohydrate Conjugates Monosaccharides N-acyl-alpha-hexosamines Monosaccharide Phosphates Organic Phosphoric Acids Oxanes Organophosphate Esters Secondary Carboxylic Acid Amides 1,2-Diols Secondary Alcohols Hemiacetals Enolates Carboxylic Acids Polyamines glucosamine amino sugar monosaccharide phosphate organic phosphate oxane phosphoric acid ester carboxamide group secondary carboxylic acid amide secondary alcohol hemiacetal 1,2-diol polyol polyamine carboxylic acid enolate ether carboxylic acid derivative amine alcohol organonitrogen compound logP -2 ALOGPS logS -1.2 ALOGPS Water Solubility 1.76e+01 g/l ALOGPS logP -3.3 ChemAxon IUPAC Name {[(2R,3R,4R,5R,6R)-5-acetamido-3,4,6-trihydroxyoxan-2-yl]methoxy}phosphonic acid ChemAxon Traditional IUPAC Name [(2R,3R,4R,5R,6R)-5-acetamido-3,4,6-trihydroxyoxan-2-yl]methoxyphosphonic acid ChemAxon Molecular Weight 301.1877 ChemAxon Monoisotopic Weight 301.056267627 ChemAxon SMILES CC(=O)N[C@H]1[C@H](O)O[C@H](COP(O)(O)=O)[C@H](O)[C@@H]1O ChemAxon Molecular Formula C8H16NO9P ChemAxon InChI InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/t4-,5-,6+,7-,8-/m1/s1 ChemAxon InChIKey InChIKey=BRGMHAYQAZFZDJ-JAJWTYFOSA-N ChemAxon Polar Surface Area (PSA) 165.78 ChemAxon Refractivity 57.9 ChemAxon Polarizability 25.76 ChemAxon Rotatable Bond Count 4 ChemAxon H Bond Acceptor Count 8 ChemAxon H Bond Donor Count 6 ChemAxon pKa (strongest acidic) 1.23 ChemAxon pKa (strongest basic) -0.79 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon ChEBI 15784 PubChem Compound 46936841 PubChem Substance 46506695 KEGG Compound C00357 PDB 16G BE0001567 Glucosamine-6-phosphate isomerase 1 Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Glucosamine-6-phosphate isomerase 1 Carbohydrate transport and metabolism D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3) GNPDA1 5q21 Cytoplasm None 6.91 32669.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:4417 GenAtlas GNPDA1 GeneCards GNPDA1 GenBank Gene Database AF048826 GenBank Protein Database 2935438 UniProtKB P46926 UniProt Accession GNPI1_HUMAN EC 3.5.99.6 GlcN6P deaminase Glucosamine-6- phosphate deaminase GNPDA Oscillin >Glucosamine-6-phosphate isomerase MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGD LSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTK VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD >870 bp ATGAAGCTCATCATCCTGGAGCACTATTCTCAGGCGAGCGAGTGGGCGGCTAAATACATC AGGAACCGTATCATCCAGTTTAACCCAGGGCCAGAGAAGTACTTCACCCTGGGGCTCCCC ACTGGGAGTACCCCACTTGGCTGCTACAAGAAGCTGATTGAATACTATAAGAATGGGGAC CTGTCCTTTAAATATGTGAAGACCTTCAACATGGATGAGTACGTGGGCCTTCCTCGAGAC CACCCGGAGAGTTACCACTCCTTCATGTGGAACAACTTCTTCAAGCACATTGACATCCAC CCAGAAAACACCCACATTCTGGATGGGAATGCAGTCGACCTACAGGCAGAATGTGATGCC TTTGAAGAGAAGATCAAGGCTGCAGGTGGGATCGAGCTATTTGTTGGAGGCATCGGCCCT GATGGACACATTGCCTTCAACGAGCCAGGCTCCAGTCTGGTGTCCAGGACCCGTGTGAAG ACGCTGGCCATGGATACCATCCTGGCCAATGCTAGGTTCTTCGATGGAGAACTCACCAAG GTGCCCACCATGGCCTTGACGGTGGGGGTGGGCACTGTCATGGATGCTAGAGAGGTGATG ATCCTTATCACAGGTGCTCACAAGGCATTTGCTCTGTACAAGGCCATCGAGGAGGGAGTG AACCACATGTGGACCGTGTCTGCCTTCCAGCAGCATCCCCGCACCGTGTTTGTGTGTGAC GAGGATGCCACCTTGGAGCTGAAAGTGAAGACTGTCAAGTATTTCAAAGGTTTAATGCTT GTTCATAACAAGTTGGTGGACCCCTTGTACAGTATCAAAGAGAAAGAAACTGAGAAAAGC CAATCTTCGAAGAAACCATACAGCGATTAG PF01182 Glucosamine_iso function glucosamine-6-phosphate deaminase activity function isomerase activity function intramolecular oxidoreductase activity function intramolecular oxidoreductase activity, interconverting aldoses and ketoses function catalytic activity process N-acetylglucosamine metabolism process metabolism process macromolecule metabolism process carbohydrate metabolism process nitrogen compound metabolism process amine metabolism process amino sugar metabolism process physiological process process glucosamine metabolism BE0001626 Glucosamine-6-phosphate deaminase Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Glucosamine-6-phosphate deaminase Carbohydrate transport and metabolism Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion nagB None 6.91 29775.0 Escherichia coli (strain K12) GenBank Gene Database M19284 GenBank Protein Database 455176 UniProtKB P0A759 UniProt Accession NAGB_ECOLI EC 3.5.99.6 GlcN6P deaminase Glucosamine-6- phosphate isomerase GNPDA >Glucosamine-6-phosphate deaminase MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQ VSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQ YEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQ VPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCD EPSTMELKVKTLRYFNELEAENIKGL >801 bp TTACAGACCTTTGATATTTTCTGCTTCTAATTCATTGAAATATCTTAAAGTCTTAACTTT CAGCTCCATGGTGGAAGGTTCATCGCACACCATGATCGCTTTCGGATGCAGTTGCAGACA GCTGATGGTCCACATATGGTTCACGCAACCTTCAACGGCGGCCTGCAGCGCCAGTGCTTT CTGGCTACCCAGCACCAGAATCATCACTTCTTCGGCATCCAGCAGTGTACCAACACCGAC AGTCAGGGCATATTTTGGCACCTGATTAACATCGTTATCAAAGAAACGAGAGTTTGCGAC GCGAGTGTCATGAGTCAGGGTTTTGATACGAGTACGAGAAGCCAGAGAAGACGCCGGTTC GTTAAATGCAATATGACCGTCGTTACCTACACCGCCCATAAACAGATGAATTTTTCCGTA AGAACGGATTTTTTCTTCATACTGGCGGCACTCGGCGTCGATATCCGGGGCGTTGCCGTT GAGAAGGTTGATGTTTTCTGCTGGAATATCAACGTGATCGAAGAAATTACGGTGCATAAA GCTGTAGTAGCTTTCCGGATGCTCTTTCGGCAGACCGACATATTCGTCCATGTTGAAGGT GACAACGTGCTTAAAGCTGACCTGGCCTGCTTTATGCATTTCGACTAACGCTTTATAGGT GGTCATCGGCGTGCCGCCAGTCGGCAGGCCCAGTACAAACGGACGATCGGCAGTCGGTTT GAACGCATTGATACGATTGACGATATGGCGAGCAGCCCATTTGCCGACCTGTTCAGCGGT AGTCAGGGGGATCAGTCTCAT PF01182 Glucosamine_iso function glucosamine-6-phosphate deaminase activity function isomerase activity function intramolecular oxidoreductase activity function intramolecular oxidoreductase activity, interconverting aldoses and ketoses function catalytic activity process metabolism process macromolecule metabolism process carbohydrate metabolism process nitrogen compound metabolism process amine metabolism process amino sugar metabolism process physiological process process glucosamine metabolism process N-acetylglucosamine metabolism "
rdf:type
ns1:drugs
rdfs:label
"16g"
owl:sameAs
?:EXPT00050

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