Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03977"
| Predicate | Value (sorted: none) |
|---|---|
| rdf:type | |
| ns1:drugCategory | |
| rdfs:label |
"N-Trimethyllysine"
|
| ns1:description |
"
experimental
This compound belongs to the alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
Alpha Amino Acids and Derivatives
Organic Compounds
Organic Acids and Derivatives
Carboxylic Acids and Derivatives
Amino Acids, Peptides, and Analogues
Amino Fatty Acids
Enolates
Polyamines
Carboxylic Acids
Monoalkylamines
carboxylic acid
enolate
polyamine
primary amine
amine
primary aliphatic amine
organonitrogen compound
Mitogens
logP
-3
ALOGPS
logS
-3
ALOGPS
Water Solubility
2.33e-01 g/l
ALOGPS
logP
-6.2
ChemAxon
IUPAC Name
[(5R)-5-amino-5-carboxypentyl]trimethylazanium
ChemAxon
Traditional IUPAC Name
N-trimethyllysine
ChemAxon
Molecular Weight
189.2752
ChemAxon
Monoisotopic Weight
189.160302926
ChemAxon
SMILES
C[N+](C)(C)CCCC[C@@H](N)C(O)=O
ChemAxon
Molecular Formula
C9H21N2O2
ChemAxon
InChI
InChI=1S/C9H20N2O2/c1-11(2,3)7-5-4-6-8(10)9(12)13/h8H,4-7,10H2,1-3H3/p+1/t8-/m1/s1
ChemAxon
InChIKey
InChIKey=MXNRLFUSFKVQSK-MRVPVSSYSA-O
ChemAxon
Polar Surface Area (PSA)
63.32
ChemAxon
Refractivity
63.79
ChemAxon
Polarizability
21.97
ChemAxon
Rotatable Bond Count
6
ChemAxon
H Bond Acceptor Count
3
ChemAxon
H Bond Donor Count
2
ChemAxon
pKa (strongest acidic)
2.41
ChemAxon
pKa (strongest basic)
9.53
ChemAxon
Physiological Charge
1
ChemAxon
Number of Rings
0
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
ChEBI
17311
PubChem Compound
115147
PubChem Substance
46505213
PDB
M3L
BE0001009
Cytochrome c
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome c
Energy production and conversion
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases
CYCS
7p15.2
Mitochondrion; mitochondrial matrix
None
10.16
11749.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:19986
GenAtlas
CYCS
GeneCards
CYCS
GenBank Gene Database
M22877
GenBank Protein Database
181242
UniProtKB
P99999
UniProt Accession
CYC_HUMAN
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA
PF00034
Cytochrom_C
function
transporter activity
function
electron transporter activity
function
tetrapyrrole binding
function
heme binding
function
binding
process
metabolism
process
cellular metabolism
process
generation of precursor metabolites and energy
process
electron transport
process
physiological process
BE0000418
Calmodulin
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Calmodulin
Involved in calcium ion binding
Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases
CALM1
14q24-q31
None
3.84
16707.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1442
GenAtlas
CALM1
GeneCards
CALM1
GenBank Gene Database
J04046
GenBank Protein Database
179888
UniProtKB
P62158
UniProt Accession
CALM_HUMAN
CaM
>Calmodulin
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK
>450 bp
ATGGCTGACCAGCTGACTGAGGAGCAGATTGCAGAGTTCAAGGAGGCCTTCTCCCTCTTT
GACAAGGATGGAGATGGCACTATCACCACCAAGGAGTTGGGGACAGTGATGAGATCCCTG
GGACAGAACCCCACTGAAGCAGAGCTGCAGGATATGATCAATGAGGTGGATGCAGATGGG
AACGGGACCATTGACTTCCCGGAGTTCCTGACCATGATGGCCAGAAAGATGAAGGACACA
GACAGTGAGGAGGAGATCCGAGAGGCGTTCCGTGTCTTTGACAAGGATGGGAATGGCTAC
ATCAGCGCCGCAGAGCTGCGTCACGTAATGACGAACCTGGGGGAGAAGCTGACCGATGAG
GAGGTGGATGAGATGATCAGGGAGGCTGACATCGATGGAGATGGCCAGGTCAATTATGAA
GAGTTTGTACAGATGATGACTGCAAAGTGA
PF00036
efhand
function
cation binding
function
calcium ion binding
function
binding
function
ion binding
"
|
| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt
The resource does not appear as an object