Resource 4-Nitrophenyl Phosphate

Predicate	Value (sorted: none)
rdfs:label	"4-Nitrophenyl Phosphate"
owl:sameAs	?:EXPT00223
ns1:description	" 330-13-2 experimental This compound belongs to the nitrophenols and derivatives. These are compounds containing a nitrophenol moiety, which consists of a benzene ring bearing both an hydroxyl group and a nitro group on two different ring carbon atoms. Nitrophenols and Derivatives Organic Compounds Benzenoids Benzene and Substituted Derivatives Phenols and Derivatives Nitrobenzenes Organophosphate Esters Organic Phosphoric Acids Nitro Compounds Nitronic Acids Organic Oxoazanium Compounds Polyamines phosphoric acid ester organic phosphate nitronic acid nitro compound polyamine organic oxoazanium organonitrogen compound amine Chromogenic Compounds logP 0.5 ALOGPS logS -2.3 ALOGPS Water Solubility 1.03e+00 g/l ALOGPS logP 0.96 ChemAxon IUPAC Name (4-nitrophenoxy)phosphonic acid ChemAxon Traditional IUPAC Name 4-nitrophenoxyphosphonic acid ChemAxon Molecular Weight 219.0887 ChemAxon Monoisotopic Weight 218.993273441 ChemAxon SMILES OP(O)(=O)OC1=CC=C(C=C1)[N+]([O-])=O ChemAxon Molecular Formula C6H6NO6P ChemAxon InChI InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12) ChemAxon InChIKey InChIKey=XZKIHKMTEMTJQX-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 112.58 ChemAxon Refractivity 46.24 ChemAxon Polarizability 16.57 ChemAxon Rotatable Bond Count 3 ChemAxon H Bond Acceptor Count 5 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 1.78 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon ChEBI 17440 PubChem Compound 378 PubChem Substance 46506564 KEGG Compound C03360 ChemSpider 369 BindingDB 24514 PDB 4NP BE0003786 Low molecular weight phosphotyrosine protein phosphatase Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Low molecular weight phosphotyrosine protein phosphatase Signal transduction mechanisms Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity ACP1 2p25 Cytoplasm None 6.73 18042.3 Human HUGO Gene Nomenclature Committee (HGNC) GNC:122 GeneCards ACP1 GenBank Gene Database M83653 GenBank Protein Database 179636 UniProtKB P24666 UniProt Accession PPAC_HUMAN Adipocyte acid phosphatase LMW-PTP LMW-PTPase Low molecular weight cytosolic acid phosphatase Red cell acid phosphatase 1 >Low molecular weight phosphotyrosine protein phosphatase MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH >477 bp ATGGCGGAACAGGCTACCAAGTCCGTGCTGTTTGTGTGTCTGGGTAACATTTGTCGATCA CCCATTGCAGAAGCAGTTTTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGG AGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCTGACTACCGAGGG CAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGATTACCAAA GAAGATTTTGCCACATTTGATTATATACTATGTATGGATGAAAGCAATCTGAGAGATTTG AATAGAAAAAGTAATCAAGTTAAAACCTGCAAAGCTAAAATTGAACTACTTGGGAGCTAT GATCCACAAAAACAACTTATTATTGAAGATCCCTATTATGGGAATGACTCTGACTTTGAG ACGGTGTACCAGCAGTGTGTCAGGTGCTGCAGAGCGTTCTTGGAGAAGGCCCACTGA PF01451 LMWPc function protein tyrosine phosphatase activity function hydrolase activity function non-membrane spanning protein tyrosine phosphatase activity function hydrolase activity, acting on ester bonds function phosphoric ester hydrolase activity function phosphoric monoester hydrolase activity function phosphoprotein phosphatase activity function catalytic activity process metabolism process protein amino acid dephosphorylation process macromolecule metabolism process biopolymer metabolism process biopolymer modification process protein modification process physiological process BE0003787 Dual specificity protein phosphatase 23 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Dual specificity protein phosphatase 23 Signal transduction mechanisms Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14) DUSP23 1q23.2 Cytoplasm, cytosol. Nucleus None 8.34 16588.0 Human HUGO Gene Nomenclature Committee (HGNC) GNC:21480 GeneCards DUSP23 GenBank Gene Database AB164404 GenBank Protein Database 44916998 UniProtKB Q9BVJ7 UniProt Accession DUS23_HUMAN LDP-3 Low molecular mass dual specificity phosphatase 3 VH1-like phosphatase Z >Dual specificity protein phosphatase 23 MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHR LRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGD AIAEIRRLRPGSIETYEQEKAVFQFYQRTK >453 bp ATGGGCGTGCAGCCCCCCAACTTCTCCTGGGTGCTTCCGGGCCGGCTGGCGGGACTGGCG CTGCCGCGGCTCCCCGCCCACTACCAGTTCCTGTTGGACCTGGGCGTGCGGCACCTGGTG TCCCTGACGGAGCGCGGGCCCCCTCACAGCGACAGCTGCCCCGGCCTCACCCTGCACCGC CTGCGCATCCCCGACTTCTGCCCGCCGGCCCCCGACCAGATCGACCGCTTCGTGCAGATC GTGGACGAGGCCAACGCACGGGGAGAGGCTGTGGGAGTGCACTGTGCTCTGGGCTTTGGC CGCACTGGCACCATGCTGGCCTGTTACCTGGTGAAGGAGCGGGGCTTGGCTGCAGGAGAT GCCATTGCTGAAATCCGACGACTACGACCCGGCTCCATCGAGACCTATGAGCAGGAGAAA GCAGTCTTCCAGTTCTACCAGCGAACGAAATAA PF00782 DSPc function protein tyrosine/serine/threonine phosphatase activity function hydrolase activity function hydrolase activity, acting on ester bonds function phosphoric ester hydrolase activity function phosphoric monoester hydrolase activity function phosphoprotein phosphatase activity function catalytic activity process metabolism process macromolecule metabolism process biopolymer metabolism process biopolymer modification process protein modification process physiological process process protein amino acid dephosphorylation "
ns1:drugCategory	?:Chromogenic Compounds
rdf:type	ns1:drugs

"4-Nitrophenyl Phosphate"

" 330-13-2 experimental This compound belongs to the nitrophenols and derivatives. These are compounds containing a nitrophenol moiety, which consists of a benzene ring bearing both an hydroxyl group and a nitro group on two different ring carbon atoms. Nitrophenols and Derivatives Organic Compounds Benzenoids Benzene and Substituted Derivatives Phenols and Derivatives Nitrobenzenes Organophosphate Esters Organic Phosphoric Acids Nitro Compounds Nitronic Acids Organic Oxoazanium Compounds Polyamines phosphoric acid ester organic phosphate nitronic acid nitro compound polyamine organic oxoazanium organonitrogen compound amine Chromogenic Compounds logP 0.5 ALOGPS logS -2.3 ALOGPS Water Solubility 1.03e+00 g/l ALOGPS logP 0.96 ChemAxon IUPAC Name (4-nitrophenoxy)phosphonic acid ChemAxon Traditional IUPAC Name 4-nitrophenoxyphosphonic acid ChemAxon Molecular Weight 219.0887 ChemAxon Monoisotopic Weight 218.993273441 ChemAxon SMILES OP(O)(=O)OC1=CC=C(C=C1)[N+]([O-])=O ChemAxon Molecular Formula C6H6NO6P ChemAxon InChI InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12) ChemAxon InChIKey InChIKey=XZKIHKMTEMTJQX-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 112.58 ChemAxon Refractivity 46.24 ChemAxon Polarizability 16.57 ChemAxon Rotatable Bond Count 3 ChemAxon H Bond Acceptor Count 5 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 1.78 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon ChEBI 17440 PubChem Compound 378 PubChem Substance 46506564 KEGG Compound C03360 ChemSpider 369 BindingDB 24514 PDB 4NP BE0003786 Low molecular weight phosphotyrosine protein phosphatase Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Low molecular weight phosphotyrosine protein phosphatase Signal transduction mechanisms Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity ACP1 2p25 Cytoplasm None 6.73 18042.3 Human HUGO Gene Nomenclature Committee (HGNC) GNC:122 GeneCards ACP1 GenBank Gene Database M83653 GenBank Protein Database 179636 UniProtKB P24666 UniProt Accession PPAC_HUMAN Adipocyte acid phosphatase LMW-PTP LMW-PTPase Low molecular weight cytosolic acid phosphatase Red cell acid phosphatase 1 >Low molecular weight phosphotyrosine protein phosphatase MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH >477 bp ATGGCGGAACAGGCTACCAAGTCCGTGCTGTTTGTGTGTCTGGGTAACATTTGTCGATCA CCCATTGCAGAAGCAGTTTTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGG AGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCTGACTACCGAGGG CAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGATTACCAAA GAAGATTTTGCCACATTTGATTATATACTATGTATGGATGAAAGCAATCTGAGAGATTTG AATAGAAAAAGTAATCAAGTTAAAACCTGCAAAGCTAAAATTGAACTACTTGGGAGCTAT GATCCACAAAAACAACTTATTATTGAAGATCCCTATTATGGGAATGACTCTGACTTTGAG ACGGTGTACCAGCAGTGTGTCAGGTGCTGCAGAGCGTTCTTGGAGAAGGCCCACTGA PF01451 LMWPc function protein tyrosine phosphatase activity function hydrolase activity function non-membrane spanning protein tyrosine phosphatase activity function hydrolase activity, acting on ester bonds function phosphoric ester hydrolase activity function phosphoric monoester hydrolase activity function phosphoprotein phosphatase activity function catalytic activity process metabolism process protein amino acid dephosphorylation process macromolecule metabolism process biopolymer metabolism process biopolymer modification process protein modification process physiological process BE0003787 Dual specificity protein phosphatase 23 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Dual specificity protein phosphatase 23 Signal transduction mechanisms Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14) DUSP23 1q23.2 Cytoplasm, cytosol. Nucleus None 8.34 16588.0 Human HUGO Gene Nomenclature Committee (HGNC) GNC:21480 GeneCards DUSP23 GenBank Gene Database AB164404 GenBank Protein Database 44916998 UniProtKB Q9BVJ7 UniProt Accession DUS23_HUMAN LDP-3 Low molecular mass dual specificity phosphatase 3 VH1-like phosphatase Z >Dual specificity protein phosphatase 23 MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHR LRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGD AIAEIRRLRPGSIETYEQEKAVFQFYQRTK >453 bp ATGGGCGTGCAGCCCCCCAACTTCTCCTGGGTGCTTCCGGGCCGGCTGGCGGGACTGGCG CTGCCGCGGCTCCCCGCCCACTACCAGTTCCTGTTGGACCTGGGCGTGCGGCACCTGGTG TCCCTGACGGAGCGCGGGCCCCCTCACAGCGACAGCTGCCCCGGCCTCACCCTGCACCGC CTGCGCATCCCCGACTTCTGCCCGCCGGCCCCCGACCAGATCGACCGCTTCGTGCAGATC GTGGACGAGGCCAACGCACGGGGAGAGGCTGTGGGAGTGCACTGTGCTCTGGGCTTTGGC CGCACTGGCACCATGCTGGCCTGTTACCTGGTGAAGGAGCGGGGCTTGGCTGCAGGAGAT GCCATTGCTGAAATCCGACGACTACGACCCGGCTCCATCGAGACCTATGAGCAGGAGAAA GCAGTCTTCCAGTTCTACCAGCGAACGAAATAA PF00782 DSPc function protein tyrosine/serine/threonine phosphatase activity function hydrolase activity function hydrolase activity, acting on ester bonds function phosphoric ester hydrolase activity function phosphoric monoester hydrolase activity function phosphoprotein phosphatase activity function catalytic activity process metabolism process macromolecule metabolism process biopolymer metabolism process biopolymer modification process protein modification process physiological process process protein amino acid dephosphorylation "

rdf:type

ns1:drugs

Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04214"

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