Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04314"
| Predicate | Value (sorted: none) |
|---|---|
| ns1:description |
"
experimental
This compound belongs to the pyrimidones. These are compounds whose pyrimidine ring bears a ketone.
Pyrimidones
Organic Compounds
Heterocyclic Compounds
Diazines
Pyrimidines and Pyrimidine Derivatives
Aminopyrimidines and Derivatives
Primary Aromatic Amines
Hydropyrimidines
Polyamines
hydropyrimidine
primary aromatic amine
polyamine
primary amine
amine
organonitrogen compound
logP
-1.4
ALOGPS
logS
-0.63
ALOGPS
Water Solubility
2.91e+01 g/l
ALOGPS
logP
-1
ChemAxon
IUPAC Name
4-amino-1-methyl-1,2-dihydropyrimidin-2-one
ChemAxon
Traditional IUPAC Name
1-methylcytosine
ChemAxon
Molecular Weight
125.1286
ChemAxon
Monoisotopic Weight
125.058911861
ChemAxon
SMILES
CN1C=CC(N)=NC1=O
ChemAxon
Molecular Formula
C5H7N3O
ChemAxon
InChI
InChI=1S/C5H7N3O/c1-8-3-2-4(6)7-5(8)9/h2-3H,1H3,(H2,6,7,9)
ChemAxon
InChIKey
InChIKey=HWPZZUQOWRWFDB-UHFFFAOYSA-N
ChemAxon
Polar Surface Area (PSA)
58.69
ChemAxon
Refractivity
32.85
ChemAxon
Polarizability
12.02
ChemAxon
Rotatable Bond Count
0
ChemAxon
H Bond Acceptor Count
3
ChemAxon
H Bond Donor Count
1
ChemAxon
pKa (strongest basic)
3.07
ChemAxon
Physiological Charge
0
ChemAxon
Number of Rings
1
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
PubChem Compound
79143
PubChem Substance
46506437
PDB
1MC
BE0001402
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
VACV
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Involved in mRNA (nucleoside-2'-O-)-methyltransferase activity
Methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-o-methylpurine cap. Also act as a regulatory subunit of polymerase that creates the 3' poly(A) tail of mRNA's; the regulatory subunit binds to poly(A) but has no catalytic activity
PAPS
None
9.94
38888.0
VACV
GenBank Gene Database
X01978
GenBank Protein Database
61396
UniProtKB
P07617
UniProt Accession
MCE_VACCW
EC 2.1.1.57
PAP-S
Poly(A) polymerase regulatory subunit
Poly(A) polymerase small subunit
VP39
>Cap-specific mRNA
MDVVSLDKPFMYFEEIDNELDYEPESANEVAKKLPYQGQLKLLLGELFFLSKLQRHGILD
GATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPILNGLRDVTLVTRFVDEEY
LRSIKKQLHPSKIILISDVRSKRGGNEPSTADLLSNYALQNVMISILNPVASSLKWRCPF
PDQWIKDFYIPHGNKMLQPFAPSYSAEMRLLSIYTGENMRLTRVTKSDAVNYEKKMYYLN
KIVRNKVVVNFDYPNQEYDYFHMYFMLRTVYCNKTFPTTKAKVLFLQQSIFRFLNIPTTS
TEKVSHEPIQRKISSKNSMSKNRNSKRSVRSNK
>1002 bp
ATGGATGTTGTGTCGTTAGATAAACCGTTTATGTATTTTGAGGAAATTGATAATGAGTTA
GATTACGAACCAGAAAGTGCAAATGAGGTCGCAAAAAAACTGCCGTATCAAGGACAGTTA
AAACTATTACTAGGAGAATTATTTTTTCTTAGTAAGTTACAGCGACACGGTATATTAGAT
GGTGCCACCGTAGTGTATATAGGATCTGCTCCCGGTACACATATACGTTATTTGAGAGAT
CATTTCTATAATTTAGGAGTGATCATCAAATGGATGCTAATTGACGGCCGCCATCATGAT
CCTATTTTAAATGGATTGCGTGATGTGACTCTAGTGACTCGGTTCGTTGATGAGGAATAT
CTACGATCCATCAAAAAACAACTGCATCCTTCTAAGATTATTTTAATTTCTGATGTGAGA
TCCAAACGAGGAGGAAATGAACCTAGTACGGCGGATTTACTAAGTAATTACGCTCTACAA
AATGTCATGATTAGTATTTTAAACCCCGTGGCGTCTAGTCTTAAATGGAGATGCCCGTTT
CCAGATCAATGGATCAAGGACTTTTATATCCCACACGGTAATAAAATGTTACAACCTTTT
GCTCCTTCATATTCAGCTGAAATGAGATTATTAAGTATTTATACCGGTGAGAACATGAGA
CTGACTCGAGTTACCAAATCAGACGCTGTAAATTATGAAAAAAAGATGTACTACCTTAAT
AAGATCGTCCGTAACAAAGTAGTTGTTAACTTTGATTATCCTAATCAGGAATATGACTAT
TTTCACATGTACTTTATGCTGAGGACCGTGTACTGCAATAAAACATTTCCTACTACTAAA
GCAAAGGTACTATTTCTACAACAATCTATATTTCGTTTCTTAAATATTCCAACAACATCA
ACTGAAAAAGTTAGTCATGAACCAATACAACGTAAAATATCTAGCAAAAATTCTATGTCT
AAAAACAGAAATAGCAAGAGATCCGTACGCAGTAATAAATAG
PF01358
PARP_regulatory
function
methyltransferase activity
function
O-methyltransferase activity
function
mRNA (nucleoside-2'-O-)-methyltransferase activity
function
catalytic activity
function
transferase activity
function
transferase activity, transferring one-carbon groups
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
RNA metabolism
process
RNA processing
process
physiological process
process
mRNA processing
process
metabolism
process
mRNA capping
process
cellular metabolism
"
|
| owl:sameAs | |
| rdfs:label |
"1-Methylcytosine"
|
| rdf:type |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt
The resource does not appear as an object