Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04343"
Predicate | Value (sorted: default) |
---|---|
rdfs:label |
"Glyoxalate, Glyoxylate"
|
rdf:type | |
ns1:description |
"
298-12-4
experimental
This compound belongs to the polyamines. These are compounds containing more than one amine group.
Polyamines
Organic Compounds
Organonitrogen Compounds
Amines
Polyamines
Enolates
Carboxylic Acids
Aldehydes
aldehyde
logP
-0.59
ALOGPS
logS
0.48
ALOGPS
Water Solubility
2.24e+02 g/l
ALOGPS
logP
-0.13
ChemAxon
IUPAC Name
2-oxoacetic acid
ChemAxon
Traditional IUPAC Name
glyoxalate, glyoxylate
ChemAxon
Molecular Weight
74.0355
ChemAxon
Monoisotopic Weight
74.00039393
ChemAxon
SMILES
OC(=O)C=O
ChemAxon
Molecular Formula
C2H2O3
ChemAxon
InChI
InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)
ChemAxon
InChIKey
InChIKey=HHLFWLYXYJOTON-UHFFFAOYSA-N
ChemAxon
Polar Surface Area (PSA)
54.37
ChemAxon
Refractivity
13.5
ChemAxon
Polarizability
5.35
ChemAxon
Rotatable Bond Count
1
ChemAxon
H Bond Acceptor Count
3
ChemAxon
H Bond Donor Count
1
ChemAxon
pKa (strongest acidic)
2.61
ChemAxon
pKa (strongest basic)
-9.2
ChemAxon
Physiological Charge
-1
ChemAxon
Number of Rings
0
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
Melting Point
98 °C
PhysProp
pKa
3.3 (at 25 °C)
DEAN,JA (1985)
ChEBI
16891
PubChem Compound
760
PubChem Substance
46507705
KEGG Compound
C00048
BindingDB
19472
PDB
GLV
SMP00721
3-Phosphoglycerate dehydrogenase deficiency
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
SMP00313
Lactic Acidemia
DB00119
Pyruvic acid
DB00121
Biotin
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00160
L-Alanine
DB00167
L-Isoleucine
DB01593
Zinc
DB04343
Glyoxalate, Glyoxylate
P49588
P24298
P11498
P21549
Q5JTZ9
SMP00055
Alanine Metabolism
DB00119
Pyruvic acid
DB00121
Biotin
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00160
L-Alanine
DB00167
L-Isoleucine
DB01593
Zinc
DB04343
Glyoxalate, Glyoxylate
P49588
P24298
P11498
P21549
Q5JTZ9
SMP00004
Glycine and Serine Metabolism
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
SMP00350
Pyruvate Carboxylase Deficiency
DB00119
Pyruvic acid
DB00121
Biotin
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00160
L-Alanine
DB00167
L-Isoleucine
DB01593
Zinc
DB04343
Glyoxalate, Glyoxylate
P49588
P24298
P11498
P21549
Q5JTZ9
SMP00179
Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
SMP00242
Dimethylglycine Dehydrogenase Deficiency
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
SMP00484
Dimethylglycinuria
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
SMP00223
Non Ketotic Hyperglycinemia
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
SMP00485
Hyperglycinemia, non-ketotic
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
SMP00352
Primary Hyperoxaluria Type I
DB00119
Pyruvic acid
DB00121
Biotin
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00160
L-Alanine
DB00167
L-Isoleucine
DB01593
Zinc
DB04343
Glyoxalate, Glyoxylate
P49588
P24298
P11498
P21549
Q5JTZ9
SMP00244
Sarcosinemia
DB00116
Tetrahydrofolic acid
DB00118
S-Adenosylmethionine
DB00119
Pyruvic acid
DB00133
L-Serine
DB00134
L-Methionine
DB00142
L-Glutamic Acid
DB00145
Glycine
DB00148
Creatine
DB00151
L-Cysteine
DB00160
L-Alanine
DB01593
Zinc
DB02951
3-Hydroxypyruvic Acid
DB02957
Orotidine-5'-Monophosphate
DB04343
Glyoxalate, Glyoxylate
DB04553
2-Oxobutanoic Acid
P21397
P05091
O75600
Q9UI17
Q9UL12
P23378
P48728
P34897
P09622
P21549
P50440
Q14353
P13196
Q93088
Q14749
Q8IVS8
O43175
Q9Y617
P78330
P20132
P49591
P34896
P41250
Q9GZT4
P35520
P32929
BE0001216
Malate synthase G
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Malate synthase G
Energy production and conversion
Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate
glcB
Cytoplasm
None
6.09
80490.0
Escherichia coli (strain K12)
GenBank Gene Database
X74547
GenBank Protein Database
517247
UniProtKB
P37330
UniProt Accession
MASZ_ECOLI
EC 2.3.3.9
MSG
>Malate synthase G
MSQTITQSRLRIDANFKRFVDEEVLPGTGLDAAAFWRNFDEIVHDLAPENRQLLAERDRI
QAALDEWHRSNPGPVKDKAAYKSFLRELGYLVPQPERVTVETTGIDSEITSQAGPQLVVP
AMNARYALNAANARWGSLYDALYGSDIIPQEGAMVSGYDPQRGEQVIAWVRRFLDESLPL
ENGSYQDVVAFKVVDKQLRIQLKNGKETTLRTPAQFVGYRGDAAAPTCILLKNNGLHIEL
QIDANGRIGKDDPAHINDVIVEAAISTILDCEDSVAAVDAEDKILLYRNLLGLMQGTLQE
KMEKNGRQIVRKLNDDRHYTAADGSEISLHGRSLLFIRNVGHLMTIPVIWDSEGNEIPEG
ILDGVMTGAIALYDLKVQKNSRTGSVYIVKPKMHGPQEVAFANKLFTRIETMLGMAPNTL
KMGIMDEERRTSLNLRSCIAQARNRVAFINTGFLDRTGDEMHSVMEAGPMLRKNQMKSTP
WIKAYERNNVLSGLFCGLRGKAQIGKGMWAMPDLMADMYSQKGDQLRAGANTAWVPSPTA
ATLHALHYHQTNVQSVQANIAQTEFNAEFEPLLDDLLTIPVAENANWSAQEIQQELDNNV
QGILGYVVRWVEQGIGCSKVPDIHNVALMEDRATLRISSQHIANWLRHGILTKEQVQASL
ENMAKVVDQQNAGDPAYRPMAGNFANSCAFKAASDLIFLGVKQPNGYTEPLLHAWRLREK
ESH
>2172 bp
ATGAGTCAAACCATAACCCAGAGCCGTTTACGCATTGACGCCAATTTTAAACGTTTTGTG
GATGAAGAAGTTTTACCGGGAACAGGGCTGGACGCTGCGGCGTTCTGGCGCAATTTTGAT
GAGATCGTTCATGATCTGGCACCAGAAAATCGTCAGTTGCTGGCAGAACGCGATCGCATT
CAGGCAGCGCTTGATGAGTGGCATCGCAGCAATCCGGGGCCGGTAAAAGATAAAGCGGCC
TATAAATCTTTCCTGCGTGAACTGGGCTACCTGGTGCCGCAACCGGAGCGCGTGACGGTG
GAAACCACGGGCATTGACAGCGAAATCACCAGCCAGGCGGGGCCGCAGCTGGTGGTTCCG
GCAATGAACGCCCGCTACGCGCTGAACGCGGCGAACGCTCGCTGGGGCTCACTGTACGAT
GCGTTATACGGCAGCGACATCATCCCGCAGGAAGGGGCGATGGTCAGCGGCTACGATCCG
CAACGCGGTGAGCAGGTTATCGCCTGGGTTCGGCGTTTCCTCGATGAATCTCTACCGCTG
GAAAACGGCAGCTATCAGGATGTGGTGGCGTTTAAGGTGGTTGATAAACAATTACGCATC
CAGTTGAAAAATGGTAAAGAAACCACGTTACGTACTCCAGCACAGTTTGTCGGTTACCGT
GGCGATGCCGCTGCGCCGACCTGCATTTTGCTGAAAAATAACGGCCTGCATATTGAGCTG
CAAATCGATGCCAATGGGCGGATTGGCAAAGACGATCCGGCGCACATCAACGATGTTATC
GTCGAAGCTGCTATCAGTACCATTCTCGACTGCGAAGATTCGGTCGCGGCGGTTGATGCG
GAAGATAAAATCCTGCTGTACCGCAACCTGCTGGGCCTGATGCAGGGGACTCTGCAAGAG
AAAATGGAGAAAAACGGTCGGCAAATCGTGCGTAAACTGAATGACGATCGTCATTACACC
GCCGCCGATGGCTCTGAAATTTCTCTGCACGGACGCTCGCTGCTGTTTATCCGCAACGTG
GGTCATTTGATGACCATTCCTGTGATTTGGGACAGCGAAGGCAATGAAATCCCGGAAGGC
ATTCTTGATGGCGTCATGACTGGCGCGATTGCCCTCTATGATTTAAAAGTGCAGAAAAAC
TCGCGCACTGGCAGCGTCTATATTGTGAAACCGAAAATGCACGGTCCGCAGGAAGTGGCG
TTCGCCAACAAACTGTTTACCCGCATTGAGACAATGCTCGGTATGGCACCGAATACCCTG
AAAATGGGCATTATGGATGAAGAACGTCGGACCTCGCTGAACTTGCGTAGCTGTATCGCT
CAGGCGCGCAACCGCGTGGCGTTCATCAATACCGGTTTCCTCGACCGTACCGGCGATGAA
ATGCATTCGGTGATGGAAGCTGGCCCGATGCTGCGTAAAAATCAGATGAAATCGACGCCT
TGGATCAAAGCCTACGAGCGTAATAACGTGCTTTCCGGTCTGTTCTGTGGGCTGCGCGGT
AAAGCGCAAATTGGTAAAGGCATGTGGGCAATGCCGGACCTGATGGCAGACATGTACAGC
CAGAAGGGCGACCAACTGCGTGCCGGGGCAAACACAGCCTGGGTTCCGTCACCAACCGCT
GCTACGCTCCATGCGCTGCACTACCACCAAACCAACGTACAGAGCGTACAAGCCAACATT
GCCCAGACCGAGTTCAATGCTGAATTTGAACCGCTGCTGGACGATCTGCTGACTATTCCG
GTTGCTGAAAACGCTAACTGGTCGGCGCAAGAGATCCAACAAGAGCTGGATAACAACGTG
CAGGGGATTCTGGGGTACGTGGTGCGCTGGGTGGAGCAGGGGATTGGTTGTTCAAAAGTG
CCGGATATTCACAATGTGGCGTTGATGGAAGACCGCGCAACGCTGCGTATCTCCAGCCAG
CATATCGCCAACTGGTTACGTCACGGTATTCTGACCAAAGAACAGGTGCAGGCGTCGCTG
GAGAATATGGCGAAAGTGGTTGATCAGCAAAACGCTGGCGATCCGGCTTATCGTCCGATG
GCGGGGAATTTCGCTAACTCGTGTGCTTTTAAAGCTGCCAGCGATTTAATCTTCCTCGGC
GTGAAACAGCCAAACGGCTATACCGAACCGTTATTACACGCCTGGCGTTTACGCGAAAAA
GAAAGTCATTAA
PF01274
Malate_synthase
function
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
function
malate synthase activity
function
catalytic activity
function
transferase activity
function
transferase activity, transferring acyl groups
process
physiological process
process
glyoxylate cycle
process
metabolism
process
cellular metabolism
process
generation of precursor metabolites and energy
process
energy derivation by oxidation of organic compounds
process
main pathways of carbohydrate metabolism
process
tricarboxylic acid cycle
BE0001761
Isocitrate lyase
Mycobacterium tuberculosis
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Isocitrate lyase
Energy production and conversion
Isocitrate = succinate + glyoxylate
icl
Cytoplasm
None
4.79
47087.0
Mycobacterium tuberculosis
GenBank Gene Database
BX842573
GenBank Protein Database
38490185
UniProtKB
P0A5H3
UniProt Accession
ACEA_MYCTU
EC 4.1.3.1
ICL
Isocitrase
Isocitratase
>Isocitrate lyase
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQL
HDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQV
VRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSH
WEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSD
VDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEA
VKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFD
LAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTG
STEEGQFH
>1287 bp
ATGTCTGTCGTCGGCACCCCGAAGAGCGCGGAGCAGATCCAGCAGGAATGGGACACGAAC
CCGCGCTGGAAGGACGTCACCCGCACCTACTCCGCCGAGGACGTCGTCGCCCTCCAGGGC
AGCGTGGTCGAGGAGCACACGCTGGCCCGCCGCGGTGCGGAGGTGCTGTGGGAGCAGCTG
CACGACCTCGAGTGGGTCAACGCGCTGGGCGCGCTGACCGGCAACATGGCCGTCCAGCAG
GTGCGCGCCGGCCTGAAGGCCATCTACCTGTCGGGCTGGCAGGTCGCCGGCGATGCCAAC
CTGTCCGGGCACACCTACCCCGACCAGAGCCTGTATCCCGCCAACTCGGTGCCGCAGGTG
GTCCGCCGGATCAACAACGCACTGCAGCGCGCCGACCAGATCGCCAAGATCGAGGGCGAT
ACTTCGGTGGAGAACTGGCTGGCGCCGATTGTCGCCGACGGCGAGGCCGGCTTTGGCGGC
GCGCTCAACGTCTACGAGCTGCAGAAAGCCCTGATCGCCGCGGGCGTTGCGGGTTCGCAC
TGGGAGGACCAGTTGGCCTCTGAGAAGAAGTGCGGCCACCTGGGCGGCAAGGTGTTGATC
CCGACCCAGCAGCACATCCGCACTTTGACGTCTGCTCGGCTCGCGGCCGATGTGGCTGAT
GTTCCCACGGTGGTGATCGCCCGTACCGACGCCGAGGCGGCCACGCTGATCACCTCCGAC
GTCGACGAGCGCGACCAGCCGTTCATCACCGGCGAGCGCACCCGGGAAGGCTTCTACCGC
ACCAAGAACGGCATCGAGCCTTGCATCGCTCGGGCGAAGGCCTACGCCCCGTTCGCCGAC
TTGATCTGGATGGAGACCGGTACCCCGGACCTCGAGGCCGCCCGGCAGTTCTCCGAGGCG
GTCAAGGCGGAGTACCCGGACCAGATGCTGGCCTACAACTGCTCGCCATCGTTCAACTGG
AAAAAGCACCTCGACGACGCCACCATCGCCAAGTTCCAGAAGGAGCTGGCAGCCATGGGC
TTCAAGTTCCAGTTCATCACGCTGGCCGGCTTCCATGCGCTGAACTACTCGATGTTCGAT
CTGGCCTACGGCTACGCCCAGAACCAGATGAGCGCGTATGTCGAACTGCAGGAACGCGAG
TTCGCCGCCGAAGAACGGGGCTACACCGCGACCAAGCACCAGCGCGAGGTCGGCGCCGGC
TACTTCGACCGGATTGCCACCACCGTGGACCCGAATTCGTCGACCACCGCGTTGACCGGT
TCCACCGAAGAGGGCCAGTTCCACTAG
PF00463
ICL
function
carbon-carbon lyase activity
function
oxo-acid-lyase activity
function
isocitrate lyase activity
function
catalytic activity
function
lyase activity
process
generation of precursor metabolites and energy
process
energy derivation by oxidation of organic compounds
process
main pathways of carbohydrate metabolism
process
glyoxylate cycle
process
physiological process
process
metabolism
process
cellular metabolism
BE0001750
Malate synthase G
Mycobacterium tuberculosis
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Malate synthase G
Energy production and conversion
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA
glcB
Cytoplasm
None
4.83
80404.0
Mycobacterium tuberculosis
GenBank Gene Database
BX842578
GenBank Protein Database
1483534
UniProtKB
P0A5J4
UniProt Accession
MASZ_MYCTU
EC 2.3.3.9
>Malate synthase G
MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDEL
QAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVP
VLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSV
PLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIE
ILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLA
AAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFE
GIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVL
GLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRK
GTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTA
WVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDN
NCQSILGYVVRWVDQGVGCSKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRA
SLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRRE
FKARAAEKPAPSDRAGDDAAR
>2226 bp
CTAGCGGGCCGCATCGTCACCGGCCCTGTCCGATGGGGCCGGCTTCTCAGCGGCCCGGGC
CTTAAACTCCCGACGACGTCGGTGCAGGATCGGCTCGGTGTAGCCGTTGGGCTGCTGGGC
CCCGGACAAGATCAGCTCCTGCGCGGCCAGGAAGGCGATACTGTCGTCGAAGTTGGGTGC
CATCGGTCGGTATGCCACGTCGCCCGCGTTTTGTCGATCGACCAACGGCGCCATCCGCTC
CAAGCTGGCCCGCACATCCGCGCTGGTGATCACACCGTGGCGCAGCCAGTTGGCCAACAA
TTGGCTGGAGATTCGCAGCGTGGCCCGGTCCTCCATGAGCGCGACGTCGTGGATGTCGGG
CACCTTCGAGCAGCCGACACCTTGATCAACCCAGCGAACCACGTAGCCGAGGATGGATTG
ACAGTTGTTGTCGACCTCTTCGCGGATCTCGTCGGGAGCCCAGGCCAATTCCTTGGCCAG
CGGAATGGTCAGCAATTGTTCGATGGTGGCGCGACGCTTCCCCGCCAGTCCTTGTTGCAC
CGCGGCGACGTCGACCTGGTGGTAGTGCAGCGCATGCAGGGTGGCCGCAGTGGGAGAGGG
AACCCAGGCGGTGCTGGCCCCGGCGCGCGGCTGGGCGATTTTTGTCTCGACCATGTCGGC
CATCAGCTCGGTCATTGTCCACATGCCCTTGCCGACCTGGGCTCGGCCGCTGAACCCGGC
GGCCAGGCCGGCATCGACGTTGTGGTCCTCGTAGGCCAAGATCCACGGCTGGCTCTTCAT
GGTGCCCTTGCGCACCATCGGGCCGGCCTCCATCGAGGTGTGGATTTCATCGCCGGTGCG
GTCCAGGAACCCGGTGTTGATGAACACCACGCGGTCCGCGGCAGCTTTGATGCACGCCTT
GAGGTTGACCGTGGTCCGGCGTTCCTCGTCCATGATGCCGATCTTCATGGTGTTTTGCGG
CAACCCCAGCACATCTTCAACCCGGCTGAACAGTTCGCAGGTAAACGCCACCTCGGCCGG
ACCGTGCATCTTCGGCTTGACGATGTAGATGGAGCCGGTGCGGCTGTTGATCAGCGGCCC
GTTGACGTCGCTGGCCTTTAGCCCGTGGATGGCGATCAGGCCGGTGAATAGGGCATCCAT
GATGCCTTCGAACACCTCGCTGCCGTCAGTGTCGACGATGGCGTCATTCGTCATCAAGTG
ACCGACGTTGCGGACGAACATGAGGCTGCGTCCAGGCAGCGTGAACTGGCCACCGCCGGG
TGCGGTGTAGTTCCGGTCCCTATTGAGCACCCGCAGGAAAGCGGTGCCGTCCTTGTCTAC
CGCTGCTGCCAGGTCGCCCTTGTTCAGGCCGAGCCAGTTCCGATAACCCAGCACCTTGTC
GGCGGCGTCCACGGCGGCCACCGAGTCCTCGAAGTCCATGATCGTGGTGATCGCGGATTC
CAGGATCACGTCCTTGACGCCGGCCCGGTCGGTGGTGCCGACCTGCGACTCCGGATCGAT
CAGGATCTCGATGTGCAAACCGTGATTGATTAGCAGCACCGATGTCGGCGACTCGGCTGC
GCCGGTGTAGCCGGCGAACTGGCCGGGGTTGGCCAGGCCGGTGGACTTATCCGGCAAGGC
AACCACGAGCTGGCCATCCTGCACTGTGAAACCGGTGGCGTCGCCAAAGGAACCCGACGA
CAGCGGAACACTGTCGTCGAGGAACTTGCGGGCATACGCGATCACCTTGTCGCCACGAAC
CTTGTTGTACGTGGGGCCTTTTTCGGCGCCGTCGGTCTCGGGGATGACATCGGTGCCATA
CAAGGCGTCGTAGAGGGAGCCCCAGCGAGCGTTGGCCGCGTTCAGAGCAAACCGCGCGTT
GAGCACCGGCACCACCAGCTGGGGGCCGGCGGTCGTGGTGATCTCAGCGTCGACACCGGA
CGTGGTGATGGTGAAGTCATCAGGTTCGGGAAGCAGGTAGCCGATCTCGGTGAGGAACTG
GCGGTAGGCATCCATGTCGATGGGCTCGATCACCCGACGCCGGTGCCACTTGTCGATCTG
CGCCTGCAGCTCGTCGCGGGCGTTCAACAGAGCTTGGTTCTGCGGGGTCAGGTCGGCGAC
GACCTTGTCGACGCCCGCCCAGAAGCTGTCCGGGTCGATATCGGTGCCAGGCAGGGCTTC
ATTGTTCACGAAGTCGTAGAGCACCCGAGCGATGCGCAAGTTGCCCACCGACACGCGATC
TGTCAT
PF01274
Malate_synthase
function
transferase activity
function
transferase activity, transferring acyl groups
function
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
function
malate synthase activity
function
catalytic activity
process
metabolism
process
cellular metabolism
process
generation of precursor metabolites and energy
process
energy derivation by oxidation of organic compounds
process
main pathways of carbohydrate metabolism
process
tricarboxylic acid cycle
process
physiological process
process
glyoxylate cycle
BE0001689
Putative regulator of ribonuclease activity
Mycobacterium tuberculosis
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Putative regulator of ribonuclease activity
Coenzyme transport and metabolism
Regulator of RNase E/rne, which inhibits the endonuclease activity and thereby leads to increase the half-life and abundance of RNAs. General modulator of RNA abundance. Does not have any methyltransferase activity
Rv3853
None
4.84
16236.0
Mycobacterium tuberculosis
GenBank Gene Database
BX842584
GenBank Protein Database
1781103
UniProtKB
P0A666
UniProt Accession
RRAAH_MYCTU
>Regulator of ribonuclease activity A
MAISFRPTADLVDDIGPDVRSCDLQFRQFGGRSQFAGPISTVRCFQDNALLKSVLSQPSA
GGVLVIDGAGSLHTALVGDVIAELARSTGWTGLIVHGAVRDAAALRGIDIGIKALGTNPR
KSTKTGAGERDVEITLGGVTFVPGDIAYSDDDGIIVV
>474 bp
GTGGCCATCTCATTTCGCCCAACCGCTGACCTCGTCGACGACATCGGGCCCGACGTGCGC
AGCTGTGACCTACAGTTCCGCCAATTCGGCGGCCGATCGCAGTTCGCCGGACCGATCAGC
ACCGTGCGGTGTTTTCAGGACAATGCGTTGCTGAAGTCGGTGCTCTCGCAGCCAAGTGCG
GGCGGTGTGCTGGTCATCGACGGCGCCGGGTCCCTGCACACCGCGTTGGTCGGTGATGTC
ATCGCCGAGTTGGCCCGCTCTACCGGCTGGACCGGGTTGATCGTCCACGGCGCGGTGCGA
GATGCCGCCGCGCTGCGCGGCATCGACATCGGCATCAAAGCGCTGGGCACCAATCCCCGC
AAGAGCACCAAGACCGGTGCCGGAGAACGCGACGTTGAAATCACGCTGGGCGGGGTGACA
TTCGTTCCGGGCGATATCGCCTACAGCGACGACGACGGCATCATCGTCGTCTGA
PF03737
Methyltransf_6
BE0000449
Monocarboxylate transporter 4
Human
substrate
# Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11101640
unknown
Monocarboxylate transporter 4
Carbohydrate transport and metabolism
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
SLC16A3
17q25
Cell membrane; multi-pass membrane protein
18-38
62-82
85-105
110-130
150-170
180-200
228-248
265-285
295-315
318-338
352-372
385-405
8.03
49470.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10924
GenAtlas
SLC16A3
GeneCards
SLC16A3
GenBank Gene Database
U81800
GenBank Protein Database
2463634
UniProtKB
O15427
UniProt Accession
MOT4_HUMAN
MCT 3
MCT 4
Solute carrier family 16 member 3
>Monocarboxylate transporter 4
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
>1398 bp
ATGGGAGGGGCCGTGGTGGACGAGGGCCCCACAGGCGTCAAGGCCCCTGACGGCGGCTGG
GGCTGGGCCGTGCTCTTCGGCTGTTTCGTCATCACTGGCTTCTCCTACGCCTTCCCCAAG
GCCGTCAGTGTCTTCTTCAAGGAGCTCATACAGGAGTTTGGGATCGGCTACAGCGACACA
GCCTGGATCTCCTCCATCCTGCTGGCCATGCTCTACGGGACAGGTCCGCTCTGCAGTGTG
TGCGTGAACCGCTTTGGCTGCCGGCCCGTCATGCTTGTGGGGGGTCTCTTTGCGTCGCTG
GGCATGGTGGCTGCGTCCTTTTGCCGGAGCATCATCCAGGTCTACCTCACCACTGGGGTC
ATCACGGGGTTGGGTTTGGCACTCAACTTCCAGCCCTCGCTCATCATGCTGAACCGCTAC
TTCAGCAAGCGGCGCCCCATGGCCAACGGGCTGGCGGCAGCAGGTAGCCCTGTCTTCCTG
TGTGCCCTGAGCCCGCTGGGGCAGCTGCTGCAGGACCGCTACGGCTGGCGGGGCGGCTTC
CTCATCCTGGGCGGCCTGCTGCTCAACTGCTGCGTGTGTGCCGCACTCATGAGGCCCCTG
GTGGTCACGGCCCAGCCGGGCTCGGGGCCGCCGCGACCCTCCCGGCGCCTGCTAGACCTG
AGCGTCTTCCGGGACCGCGGCTTTGTGCTTTACGCCGTGGCCGCCTCGGTCATGGTGCTG
GGGCTCTTCGTCCCGCCCGTGTTCGTGGTGAGCTACGCCAAGGACCTGGGCGTGCCCGAC
ACCAAGGCCGCCTTCCTGCTCACCATCCTGGGCTTCATTGACATCTTCGCGCGGCCGGCC
GCGGGCTTCGTGGCGGGGCTTGGGAAGGTGCGGCCCTACTCCGTCTACCTCTTCAGCTTC
TCCATGTTCTTCAACGGCCTCGCGGACCTGGCGGGCTCTACGGCGGGCGACTACGGCGGC
CTCGTGGTCTTCTGCATCTTCTTTGGCATCTCCTACGGCATGGTGGGGGCCCTGCAGTTC
GAGGTGCTCATGGCCATCGTGGGCACCCACAAGTTCTCCAGTGCCATTGGCCTGGTGCTG
CTGATGGAGGCGGTGGCCGTGCTCGTCGGGCCCCCTTCGGGAGGCAAACTCCTGGATGCG
ACCCACGTCTACATGTACGTGTTCATCCTGGCGGGGGCCGAGGTGCTCACCTCCTCCCTG
ATTTTGCTGCTGGGCAACTTCTTCTGCATTAGGAAGAAGCCCAAAGAGCCACAGCCTGAG
GTGGCGGCCGCGGAGGAGGAGAAGCTCCACAAGCCTCCTGCAGACTCGGGGGTGGACTTG
CGGGAGGTGGAGCATTTCCTGAAGGCTGAGCCTGAGAAAAACGGGGAGGTGGTTCACACC
CCGGAAACAAGTGTCTGA
PF07690
MFS_1
component
cell
component
intrinsic to membrane
component
integral to membrane
component
membrane
function
monocarboxylic acid transporter activity
function
transporter activity
function
monocarboxylate porter activity
function
organic acid transporter activity
function
carboxylic acid transporter activity
process
transport
process
organic anion transport
process
ion transport
process
anion transport
process
physiological process
process
cellular physiological process
"
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owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt
The resource appears as object in 17 triples