Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04456"

Predicate	Value (sorted: default)
rdfs:label	"Trihydroxyarsenite(Iii)"
rdf:type	ns1:drugs
ns1:description	" experimental This compound belongs to the metalloid oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a metalloid. Metalloid Oxides Inorganic Compounds Mixed Metal/Non-metal Compounds Metalloid Organides Metalloid Oxides logP -0.86 ChemAxon IUPAC Name arsorous acid ChemAxon Traditional IUPAC Name trihydroxyarsenite(iii) ChemAxon Molecular Weight 125.9436 ChemAxon Monoisotopic Weight 125.929815379 ChemAxon SMILES O[As](O)O ChemAxon Molecular Formula AsH3O3 ChemAxon InChI InChI=1S/AsH3O3/c2-1(3)4/h2-4H ChemAxon InChIKey InChIKey=GCPXMJHSNVMWNM-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 60.69 ChemAxon Refractivity 7.69 ChemAxon Polarizability 6.27 ChemAxon Rotatable Bond Count 0 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 3 ChemAxon pKa (strongest acidic) 6.84 ChemAxon pKa (strongest basic) -6.2 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon ChEBI 49900 PubChem Compound 545 PubChem Substance 46508436 ChemSpider 530 PDB TAS BE0001885 Arsenical pump-driving ATPase Escherichia coli # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Arsenical pump-driving ATPase Inorganic ion transport and metabolism Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents arsA Cytoplasmic None 5.64 63189.0 Escherichia coli GenBank Gene Database J02591 GenBank Protein Database 151857 UniProtKB P08690 UniProt Accession ARSA1_ECOLX Arsenical resistance ATPase Arsenite-translocating ATPase Arsenite-transporting ATPase EC 3.6.3.16 >Arsenical pump-driving ATPase MQFLQNIPPYLFFTGKGGVGKTSISCATAIRLAEQGKRVLLVSTDPASNVGQVFSQTIGI TIQAIASVPGLSALEIDPQAAAQQYRARIVDPIKGVLPDDVVSSINEQLSGACTTEIAAF DEFTGLLTDASLLTRFDHIIFDTAPTGHTIRLLQLPGAWSSFIDSNPEGASCLGPMAGLE KQREQYAYAVEALSDPKRTRLVLVARLQKSTLQEVARTHLELAAIGLKNQYLVINGVLPK TEAANDTLAAAIWEREQEALANLPADLAGLPTDTLFLQPVNMVGVSALSRLLSTQPVASP SSDEYLQQRPDIPSLSALVDDIARNEHGLIMLMGKGGVGKTTMAAAIAVRLADMGFDVHL TTSDPAAHLSMTLNGSLNNLQVSRIDPHEETERYRQHVLETKGKELDEAGKRLLEEDLRS PCTEEIAVFQAFSRVIREAGKRFVVMDTAPTGHTLLLLDATGAYHREIAKKMGEKGHFTT PMMLLQDPERTKVLLVTLPETTPVLEAANLQADLERAGIHPWGWIINNSLSIADTRSPLL RMRAQQELPQIESVKRQHASRVALVPVLASEPTGIDKLKQLAG >1752 bp ATGCAATTCTTACAGAATATCCCCCCTTATCTGTTTTTTACGGGTAAAGGAGGCGTGGGT AAAACCTCTATTTCCTGCGCCACGGCGATCCGTCTGGCAGAACAGGGGAAACGGGTGCTG CTGGTCAGTACCGATCCGGCCTCAAACGTAGGCCAGGTGTTTAGCCAGACGATTGGCATT ACCATTCAGGCAATAGCCTCTGTTCCTGGATTGTCGGCTCTTGAGATTGATCCTCAGGCT GCTGCACAACAGTACCGGGCCAGAATCGTTGACCCTATTAAAGGCGTCCTGCCTGATGAC GTTGTTTCCAGCATCAACGAACAACTGTCAGGTGCATGCACAACAGAGATTGCGGCTTTT GATGAATTTACCGGATTACTGACAGATGCCTCTCTGCTGACGCGGTTTGACCATATCATT TTTGATACCGCGCCGACGGGTCACACCATTCGCCTTCTGCAGTTGCCGGGCGCCTGGAGT AGCTTTATTGACAGCAATCCCGAGGGCGCGTCCTGTCTCGGCCCAATGGCGGGGCTGGAA AAGCAGCGTGAACAGTATGCCTATGCTGTTGAAGCGTTGTCTGATCCAAAGCGTACCCGA CTGGTATTAGTTGCTCGTCTGCAAAAATCCACGTTGCAGGAAGTCGCCCGGACTCATCTG GAACTTGCCGCCATCGGCCTTAAAAATCAGTACCTGGTTATTAATGGCGTTCTGCCCAAA ACTGAAGCGGCAAACGATACACTGGCTGCTGCAATATGGGAGCGTGAACAGGAGGCGCTG GCCAATCTTCCCGCTGATCTTGCAGGTTTGCCAACTGACACATTATTTCTCCAGCCGGTC AATATGGTCGGTGTGTCTGCGCTCAGCAGGCTTCTCTCCACTCAGCCTGTAGCGTCGCCA TCCTCGGATGAATACCTGCAACAGCGGCCTGATATTCCGTCACTTTCTGCGTTGGTTGAT GATATTGCCCGTAATGAACATGGCCTGATTATGCTGATGGGTAAAGGTGGCGTGGGGAAA ACCACGATGGCTGCTGCCATTGCTGTCAGGCTGGCCGACATGGGATTTGATGTCCATCTG ACAACATCTGATCCTGCGGCGCATCTCAGCATGACCCTGAACGGTAGCCTTAACAACCTG CAGGTCAGCAGGATCGATCCTCACGAGGAAACGGAACGCTATCGTCAGCATGTTCTTGAA ACAAAGGGAAAAGAACTGGACGAAGCGGGAAAACGCCTGCTGGAAGAGGACTTACGCTCA CCTTGCACTGAGGAAATTGCTGTTTTCCAGGCCTTTTCACGGGTGATTCGTGAAGCGGGT AAACGTTTCGTGGTGATGGATACGGCTCCGACCGGACACACGCTGTTGCTGCTGGATGCT ACAGGCGCGTACCACCGCGAAATTGCGAAGAAAATGGGAGAAAAAGGCCATTTCACCACA CCGATGATGCTGCTTCAGGATCCGGAGCGCACTAAAGTGTTACTGGTCACGCTGCCGGAA ACCACGCCCGTGCTTGAAGCGGCAAATTTACAGGCCGACCTTGAGCGTGCAGGCATTCAC CCCTGGGGCTGGATTATCAATAACAGCCTTTCCATTGCGGATACCCGTTCGCCACTGCTT CGTATGCGGGCACAACAGGAACTTCCGCAGATAGAGAGCGTTAAACGCCAGCACGCCAGC CGTGTCGCTCTTGTTCCCGTACTGGCGTCAGAACCAACCGGCATCGACAAACTCAAACAA CTTGCTGGGTAA PF02374 ArsA_ATPase component membrane component cell function binding function ATP binding function catalytic activity function hydrolase activity, acting on acid anhydrides function hydrolase activity function hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides function nucleotide binding function pyrophosphatase activity function purine nucleotide binding function nucleoside-triphosphatase activity function adenyl nucleotide binding process ion transport process physiological process process cellular physiological process process anion transport process transport BE0001321 Arsenate reductase Escherichia coli # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Arsenate reductase Inorganic ion transport and metabolism Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of arsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance arsC None 4.99 15831.0 Escherichia coli GenBank Gene Database J02591 GenBank Protein Database 151859 UniProtKB P08692 UniProt Accession ARSC1_ECOLX Arsenical pump modifier EC 1.20.4.1 >Arsenate reductase MSNITIYHNPACGTSRNTLEMIRNSGTEPTIILYLENPPSRDELVKLIADMGISVRALLR KNVEPYEQLGLAEDKFTDDQLIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLDILQDAQ KGAFTKEDGEKVVDEAGKRLK >426 bp ATGAGCAACATCACTATTTATCATAACCCAGCCTGCGGCACCTCGCGTAATACGCTGGAG ATGATCCGCAACAGCGGTACCGAGCCGACCATTATTCTTTACCTTGAAAACCCGCCTTCG AGGGATGAGCTGGTTAAACTTATTGCCGATATGGGTATTTCAGTACGAGCGCTGCTGCGT AAAAACGTTGAACCTTACGAGCAACTGGGTCTTGCAGAAGATAAATTTACTGACGATCAG CTCATCGACTTTATGTTGCAACACCCAATTCTGATTAACCGTCCGATCGTGGTTACGCCG CTGGGAACCAGACTGTGCCGTCCTTCTGAAGTGGTTCTGGATATCCTACAGGATGCGCAG AAAGGGGCTTTCACTAAGGAAGACGGTGAAAAAGTCGTTGATGAAGCAGGAAAACGGCTG AAATAA PF03960 ArsC function catalytic activity function oxidoreductase activity function arsenate reductase activity function arsenate reductase (glutaredoxin) activity process physiological process process metabolism process cellular metabolism process generation of precursor metabolites and energy process electron transport "
owl:sameAs	?:EXPT03008

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

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