Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04461"

Predicate	Value (sorted: default)
rdfs:label	"Coproporphyrin Iii"
rdf:type	ns1:drugs
ns1:description	" experimental Ichiro Kojima, Kenji Maruhashi, Yasuo Fujiwara, "Process for producing coproporphyrin III." U.S. Patent US4334021, issued September, 1978. logP 1.96 ALOGPS logS -4.8 ALOGPS Water Solubility 1.12e-02 g/l ALOGPS logP 0.43 ChemAxon Molecular Weight 656.7248 ChemAxon Monoisotopic Weight 656.284614276 ChemAxon SMILES Cc1c2Cc3nc(Cc4nc(Cc5nc(Cc(n2)c1CCC(O)=O)c(C)c5CCC(O)=O)c(C)c4CCC(O)=O)c(CCC(O)=O)c3C ChemAxon Molecular Formula C36H40N4O8 ChemAxon Polar Surface Area (PSA) 200.76 ChemAxon Refractivity 173.57 ChemAxon Polarizability 69.35 ChemAxon Rotatable Bond Count 12 ChemAxon H Bond Acceptor Count 12 ChemAxon H Bond Donor Count 4 ChemAxon pKa (strongest acidic) 2.76 ChemAxon pKa (strongest basic) 5.38 ChemAxon Physiological Charge -4 ChemAxon Number of Rings 5 ChemAxon Bioavailability 0 ChemAxon MDDR-Like Rule true ChemAxon ChEBI 27609 PubChem Compound 321 PubChem Substance 46508802 KEGG Compound C05770 PDB CP3 SMP00344 Acute Intermittent Porphyria DB00145 Glycine DB01592 Iron DB01593 Zinc DB02285 Protoporphyrin Ix DB03435 Uridine-5'-Diphosphate DB04461 Coproporphyrin Iii P13196 P13716 P08397 P10746 P06132 P36551 P50336 Q8N4E7 P22830 Q12887 Q7KZN9 P09601 P53004 O75310 P08236 SMP00345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease DB00145 Glycine DB01592 Iron DB01593 Zinc DB02285 Protoporphyrin Ix DB03435 Uridine-5'-Diphosphate DB04461 Coproporphyrin Iii P13196 P13716 P08397 P10746 P06132 P36551 P50336 Q8N4E7 P22830 Q12887 Q7KZN9 P09601 P53004 O75310 P08236 SMP00342 Hereditary Coproporphyria (HCP) DB00145 Glycine DB01592 Iron DB01593 Zinc DB02285 Protoporphyrin Ix DB03435 Uridine-5'-Diphosphate DB04461 Coproporphyrin Iii P13196 P13716 P08397 P10746 P06132 P36551 P50336 Q8N4E7 P22830 Q12887 Q7KZN9 P09601 P53004 O75310 P08236 SMP00024 Porphyrin Metabolism DB00145 Glycine DB01592 Iron DB01593 Zinc DB02285 Protoporphyrin Ix DB03435 Uridine-5'-Diphosphate DB04461 Coproporphyrin Iii P13196 P13716 P08397 P10746 P06132 P36551 P50336 Q8N4E7 P22830 Q12887 Q7KZN9 P09601 P53004 O75310 P08236 SMP00346 Porphyria Variegata (PV) DB00145 Glycine DB01592 Iron DB01593 Zinc DB02285 Protoporphyrin Ix DB03435 Uridine-5'-Diphosphate DB04461 Coproporphyrin Iii P13196 P13716 P08397 P10746 P06132 P36551 P50336 Q8N4E7 P22830 Q12887 Q7KZN9 P09601 P53004 O75310 P08236 BE0001629 Uroporphyrinogen decarboxylase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Uroporphyrinogen decarboxylase Coenzyme transport and metabolism Uroporphyrinogen III = coproporphyrinogen + 4 CO(2) UROD 1p34 Cytoplasm None 6.06 40787.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:12591 GenAtlas UROD GeneCards UROD GenBank Gene Database M14016 GenBank Protein Database 340181 UniProtKB P06132 UniProt Accession DCUP_HUMAN EC 4.1.1.37 UPD URO-D >Uroporphyrinogen decarboxylase MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCR SPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLER LRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRW LYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDV AKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVT LQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKH SRLLRQN >1104 bp ATGGAAGCGAATGGGTTGGGACCTCAGGGTTTTCCGGAGCTGAAGAATGACACATTCCTG CGAGCAGCTTGGGGAGAGGAAACAGACTACACTCCCGTTTGGTGCATGCGCCAGGCAGGC CGTTACTTACCAGAGTTTAGGGAAACCCGGGCTGCCCAGGACTTTTTCAGCACGTGTCGC TCTCCTGAGGCCTGCTGTGAACTGACTCTGCAGCCACTGCGTCGCTTCCCTCTGGATGCT GCCATCATTTTCTCCGACATCCTTGTTGTACCCCAGGCACTGGGCATGGAGGTGACCATG GTACCTAGCAAAGGACCCAGCTTCCCAGAGCCATTAAGAGAAGAGCAGGACCTAGAAGCG CTACGGGATCCAGAAGTGGTAGCCTCTGAGCTAGGCTATGTGTTCCAAGCCATCACCCTT ACCCGACAACGACTGGCTGGACGTGTGCCGCTGATTGGCTTTGCTGGTGCCCCATGGACC CTGATGACATACATGGTTGAGGGTGGTGGCTCAAGCACCATGGCTCAGGCCAAGCGCTGG CTCTATCAGAGACCTCAGGCTAGTCACCAGCTGCTTCGCATCCTCACTGATGCTCTGGTC CCATATCTGGTAGGACAAGTGGTGGCTGGTGCCCAGGCATTGCAGCTGTTTGAGTCCCAT GCAGGGCATCTTGGCCCACAGCTCTTCAACAAGTTTGCACTGCCTTACATCCGTGATGTG GCCAAGCAAGTGAAGGCCAGGTTGCGGGAGGCAGGCCTGGCACCAGTGCCCATGATCATC TTTGCTAAGGATGGGCATTTTGCCCTGGAGGAGCTGGCCCAAGCTGGCTATGAGGTGGTT GGGCTTGACTGGACAGTGGCCCCAAAGAAAGCCCGGGAGTGTGTGGGGAAGACGGTGACA TTGCAGGGCAACTTGGACCCCTGTGCCTTGTATGCATCTGAGGAGGAGATCGGGCAGTTG GTGAAGCAGATGCTGGATGACTTTGGACCACATCGCTACATTGCCAACTTGGGCCATGGG CTTTATCCTGACATGGACCCAGAACATGTGGGCGCCTTTGTGGATGCTGTGCATAAACAC TCACGTCTGCTTCGACAGAACTGA PF01208 URO-D function uroporphyrinogen decarboxylase activity function catalytic activity function lyase activity function carbon-carbon lyase activity function carboxy-lyase activity process physiological process process metabolism process cellular metabolism process heterocycle metabolism process porphyrin metabolism process porphyrin biosynthesis "
owl:sameAs	?:Glycine ?:Iron ?:Zinc ?:Protoporphyrin Ix ?:Uridine-5'-Diphosphate ?:Coproporphyrin Iii ?:EXPT00993

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

The resource appears as object in 6 triples

Context graph