Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB05773"

No prefix for http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/.
PredicateValue (sorted: default)
rdfs:label
"ado-trastuzumab emtansine"
rdf:type
ns1:drugs
ns1:description
"Ado-trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) as an investigational drug, is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-microtubule agent, DM1 (a maytansine derivative)--to produce cell cycle arrest and apoptosis. Ado-trastuzumab emtansine is marketed under the brand name Kadcyla and is indicated for use in HER2-positive, metastatic breast cancer patients who have already used taxane and/or trastuzumab for metastatic disease or had their cancer recur within 6 months of adjuvant treatment. The FDA label has two precautions. First that ado-trastuzumab emtansine and trastuzumab cannot be interchanged. Second that there is a black box warning of serious side effects such as hepatotoxicity, embryo-fetal toxicity, and cardiac toxicity. "
ns1:drugCategory
?:Antineoplastic Agents
?:Monoclonal antibodies
?:Tubulin Modulators
ns1:interactsWith
?:Natalizumab
?:Phenytoin
?:Pimecrolimus
?:Clozapine
?:Tacrolimus
?:Belimumab
?:Tofacitinib
owl:sameAs
?:Natalizumab
?:Phenytoin
?:Pimecrolimus
?:Clozapine
?:Tacrolimus
?:Belimumab
?:Tofacitinib

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

The resource appears as object in 14 triples

Context graph