Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB07763"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE"
|
| rdf:type | |
| ns1:description |
"
experimental
This compound belongs to the phenylhydrazines. These are compounds containing a phenylhydrazide moiety, which consists of an hydrazide substituent attacthed to a phenyl group.
Phenylhydrazines
Organic Compounds
Benzenoids
Benzene and Substituted Derivatives
Phenylhydrazines
Fluorobenzenes
Oxazolidinediones
Aryl Fluorides
N-substituted Carboxylic Acid Imides
Carboxylic Acid Hydrazides
Polyamines
Carboxylic Acid Amides
Organofluorides
Hydrazines and Derivatives
fluorobenzene
oxazolidinedione
aryl fluoride
carboxylic acid imide, n-substituted
aryl halide
carboxamide group
carboxylic acid hydrazide
polyamine
carboxylic acid derivative
organohalogen
hydrazine derivative
organofluoride
amine
organonitrogen compound
logP
3.44
ALOGPS
logS
-4.3
ALOGPS
Water Solubility
1.45e-02 g/l
ALOGPS
logP
4.04
ChemAxon
IUPAC Name
(5S)-5-(2,4-difluorophenyl)-5-methyl-3-(phenylamino)-1,3-oxazolidine-2,4-dione
ChemAxon
Traditional IUPAC Name
(5S)-5-(2,4-difluorophenyl)-5-methyl-3-(phenylamino)-1,3-oxazolidine-2,4-dione
ChemAxon
Molecular Weight
318.2749
ChemAxon
Monoisotopic Weight
318.08159867
ChemAxon
SMILES
C[C@]1(OC(=O)N(NC2=CC=CC=C2)C1=O)C1=CC=C(F)C=C1F
ChemAxon
Molecular Formula
C16H12F2N2O3
ChemAxon
InChI
InChI=1S/C16H12F2N2O3/c1-16(12-8-7-10(17)9-13(12)18)14(21)20(15(22)23-16)19-11-5-3-2-4-6-11/h2-9,19H,1H3/t16-/m0/s1
ChemAxon
InChIKey
InChIKey=OZZFJGCAYWBVBI-INIZCTEOSA-N
ChemAxon
Polar Surface Area (PSA)
58.64
ChemAxon
Refractivity
78.28
ChemAxon
Polarizability
28.43
ChemAxon
Rotatable Bond Count
3
ChemAxon
H Bond Acceptor Count
3
ChemAxon
H Bond Donor Count
1
ChemAxon
pKa (strongest acidic)
14.26
ChemAxon
pKa (strongest basic)
-9.4
ChemAxon
Physiological Charge
0
ChemAxon
Number of Rings
3
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
Ghose Filter
true
ChemAxon
PubChem Compound
9547935
PubChem Substance
99444234
ChemSpider
7826870
PDB
FDN
BE0003854
Cytochrome c1, heme protein, mitochondrial
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome c1, heme protein, mitochondrial
Energy production and conversion
This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain
CYC1
8q24.3
Mitochondrion inner membrane
292-306
9.25
35389.5
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:2579
GeneCards
CYC1
GenBank Gene Database
M16597
GenBank Protein Database
181238
UniProtKB
P08574
UniProt Accession
CY1_HUMAN
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Cytochrome c-1
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
>Cytochrome c1, heme protein, mitochondrial
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVM
LSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQV
CASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYP
NSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQ
AIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLV
PLVYTIKRHKWSVLKSRKLAYRPPK
PF02167
Cytochrom_C1
component
cell
component
membrane
component
organelle membrane
component
organelle inner membrane
component
mitochondrial inner membrane
component
mitochondrial electron transport chain
function
transporter activity
function
electron transporter activity
process
generation of precursor metabolites and energy
process
electron transport
process
physiological process
process
metabolism
process
cellular metabolism
BE0000938
Cytochrome b
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b
Energy production and conversion
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MT-CYB
-
None
8.22
42730.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7427
GenAtlas
MT-CYB
GeneCards
MT-CYB
GenBank Gene Database
V00662
GenBank Protein Database
13016
UniProtKB
P00156
UniProt Accession
CYB_HUMAN
>Cytochrome b
MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDAS
TAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILL
LATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFT
FHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLM
TLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILI
LAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFT
TILILMPTISLIENKMLKWA
>1140 bp
ATGACCCCAATACGCAAAATTAACCCCCTAATAAAATTAATTAACCACTCATTCATCGAC
CTCCCCACCCCATCCAACATCTCCGCATGATGAAACTTCGGCTCACTCCTTGGCGCCTGC
CTGATCCTCCAAATCACCACAGGACTATTCCTAGCCATGCACTACTCACCAGACGCCTCA
ACCGCCTTTTCATCAATCGCCCACATCACTCGAGACGTAAATTATGGCTGAATCATCCGC
TACCTTCACGCCAATGGCGCCTCAATATTCTTTATCTGCCTCTTCCTACACATCGGGCGA
GGCCTATATTACGGATCATTTCTCTACTCAGAAACCTGAAACATCGGCATTATCCTCCTG
CTTGCAACTATAGCAACAGCCTTCATAGGCTATGTCCTCCCGTGAGGCCAAATATCATTC
TGAGGGGCCACAGTAATTACAAACTTACTATCCGCCATCCCATACATTGGGACAGACCTA
GTTCAATGAATCTGAGGAGGCTACTCAGTAGACAGTCCCACCCTCACACGATTCTTTACC
TTTCACTTCATCTTGCCCTTCATTATTGCAGCCCTAGCAACACTCCACCTCCTATTCTTG
CACGAAACGGGATCAAACAACCCCCTAGGAATCACCTCCCATTCCGATAAAATCACCTTC
CACCCTTACTACACAATCAAAGACGCCCTCGGCTTACTTCTCTTCCTTCTCTCCTTAATG
ACATTAACACTATTCTCACCAGACCTCCTAGGCGACCCAGACAATTATACCCTAGCCAAC
CCCTTAAACACCCCTCCCCACATCAAGCCCGAATGATATTTCCTATTCGCCTACACAATT
CTCCGATCCGTCCCTAACAAACTAGGAGGCGTCCTTGCCCTATTACTATCCATCCTCATC
CTAGCAATAATCCCCATCCTCCATATATCCAAACAACAAAGCATAATATTTCGCCCACTA
AGCCAATCACTTTATTGACTCCTAGCCGCAGACCTCCTCATTCTAACCTGAATCGGAGGA
CAACCAGTAAGCTACCCTTTTACCATCATTGGACAAGTAGCATCCGTACTATACTTCACA
ACAATCCTAATCCTAATACCAACTATCTCCCTAATTGAAAACAAAATACTCAAATGGGCC
PF00032
Cytochrom_B_C
PF00033
Cytochrom_B_N
component
cell
component
membrane
function
oxidoreductase activity
function
catalytic activity
process
metabolism
process
cellular metabolism
process
generation of precursor metabolites and energy
process
electron transport
process
physiological process
BE0001005
Cytochrome b-c1 complex subunit 1, mitochondrial
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit 1, mitochondrial
Involved in metalloendopeptidase activity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1
UQCRC1
3p21.3
Mitochondrion; mitochondrial inner membrane
None
6.32
52646.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12585
GenAtlas
UQCRC1
GeneCards
UQCRC1
GenBank Gene Database
L16842
GenBank Protein Database
515634
UniProtKB
P31930
UniProt Accession
QCR1_HUMAN
Core I protein
EC 1.10.2.2
Ubiquinol-cytochrome-c reductase complex core protein 1, mitochondrial precursor
>Ubiquinol-cytochrome-c reductase complex core protein 1, mitochondrial precursor
MAASVVCRAATAGAQVLLRARRSPALLRTPALRSTATFAQALQFVPETQVSLLDNGLRVA
SEQSSQPTCTVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRPGSALEKEVESMGAHL
NAYSTREHTAYYIKALSKDLPKAVELLGDIVQNCSLEDSQIEKERDVILREMQENDASMR
DVVFNYLHATAFQGTPLAQAVEGPSENVRKLSRADLTEYLSTHYKAPRMVLAAAGGVEHQ
QLLDLAQKHLGGIPWTYAEDAVPTLTPCRFTGSEIRHRDDALPFAHVAIAVEGPGWASPD
NVALQVANAIIGHYDCTYGGGVHLSSPLASGAVANKLCQSFQTFSICYAETGLLGAHFVC
DRMKIDDMMFVLQGQWMRLCTSATESEVARGKNILRNALVSHLDGTTPVCEDIGRSLLTY
GRRIPLAEWESRIAEVDASVVREICSKYIYDQCPAVAGYGPIEQLPDYNRIRSGMFWLRF
>1443 bp
ATGGCGGCGTCCGTGGTCTGTCGGGCCGCTACCGCCGGGGCACAAGTGCTATTGCGCGCC
CGCCGCTCGCCGGCCCTGCTGCGGACGCCAGCCTTGCGGAGTACGGCAACCTTCGCTCAG
GCGCTCCAGTTCGTGCCGGAGACGCAGGTTAGCCTGCTGGACAACGGCCTGCGTGTGGCC
TCCGAGCAGTCCTCTCAGCCCACTTGCACGGTGGGAGTGTGGATTGATGTTGGCAGCCGT
TTTGAGACTGAGAAGAATAATGGGGCAGGCTACTTTTTGGAGCATCTGGCTTTCAAGGGA
ACAAAGAATCGGCCTGGCAGTGCCCTGGAGAAGGAGGTGGAGAGCATGGGGGCCCATCTT
AATGCCTACAGCACCCGGGAGCACACAGCTTACTACATCAAGGCGCTGTCCAAGGATCTG
CCGAAAGCTGTGGAGCTCCTGGGTGACATTGTGCAGAACTGTAGTCTGGAAGACTCACAG
ATTGAGAAGGAACGTGATGTGATCCTGCGGGAGATGCAGGAGAATGATGCATCTATGCGA
GATGTGGTCTTTAACTACCTGCATGCCACAGCATTCCAGGGCACACCTCTAGCCCAGGCT
GTGGAGGGGCCCAGTGAGAATGTCAGGAAGCTGTCTCGTGCAGACTTGACCGAGTACCTC
AGCACACATTACAAGGCCCCTCGAATGGTGCTGGCAGCAGCTGGAGGAGTGGAGCACCAG
CAACTGTTAGACCTCGCCCAGAAGCACCTCGGTGGCATCCCATGGACATATGCAGAGGAC
GCTGTGCCCACTCTTACTCCATGCCGCTTCACTGGCAGTGAGATCCGCCACCGTGATGAT
GCTCTACCTTTTGCCCACGTGGCCATTGCAGTAGAGGGTCCTGGCTGGGCCAGCCCGGAC
AGTGTGGCCTTGCAAGTGGCCAATGCCATCATCGGCCACTATGACTGCACTTATGGTGGT
GGCGTGCACCTGTCCAGCCCACTGGCTTCAGGTGCTGTGGCCAACAAGCTATGCCAGAGT
TTCCAGACCTTCAGCATCTGCTATGCAGAGACGGGCTTGCTGGGTGCACACTTTGTCTGT
GACCGAATGAAAATCGATGACATGATGTTCGTCCTGCAAGGGCAGTGGATGCGCCTGTGT
ACCAGTGCCACGGAGAGTGAGGTGGCCCGGGGCAAAAACATCCTCAGAAATGCCCTGGTA
TCTCATCTAGATGGCACTACTCCTGTGTGTGAGGACATCGGACGCAGCCTCCTGACCTAT
GGCCGCCGCATCCCCCTGGCTGAATGGGAAAGCCGGATTGCGGAGGTGGATGCCAGTGTG
GTACGTGAGATCTGCTCCAAGTACATCTATGACCAGTGCCCAGCAGTGGCTGGATATGGC
CCCATTGAGCAGCTCCCAGACTACAACCGGATCCGTAGCGGCATGTTCTGGCTGCGCTTC
TAG
PF00675
Peptidase_M16
PF05193
Peptidase_M16_C
function
catalytic activity
function
hydrolase activity
function
peptidase activity
function
endopeptidase activity
function
metalloendopeptidase activity
process
metabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
BE0003855
Cytochrome b-c1 complex subunit 2, mitochondrial
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit 2, mitochondrial
Involved in metalloendopeptidase activity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex
UQCRC2
16p12
Mitochondrion inner membrane
None
8.92
48442.6
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:12586
GeneCards
UQCRC2
GenBank Gene Database
J04973
GenBank Protein Database
180928
UniProtKB
P22695
UniProt Accession
QCR2_HUMAN
Complex III subunit 2
Core protein II
Ubiquinol-cytochrome-c reductase complex core protein 2
>Cytochrome b-c1 complex subunit 2, mitochondrial
MKLLTRAGSFSRFYSLKVAPKVKATAAPAGAPPQPQDLEFTKLPNGLVIASLENYSPVSR
IGLFIKAGSRYEDFSNLGTTHLLRLTSSLTTKGASSFKITRGIEAVGGKLSVTATRENMA
YTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAA
AYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNM
RGGLGLSGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVK
RGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLFGIYTISQATAAGDVIKAAYNQVKT
IAQGNLSNTDVQAAKNKLKAGYLMSVESSECFLEEVGSQALVAGSYMPPSTVLQQIDSVA
NADIINAAKKFVSGQKSMAASGNLGHTPFVDEL
>1362 bp
ATGAAGCTACTAACCAGAGCCGGCTCTTTCTCGAGATTTTATTCCCTCAAAGTTGCCCCC
AAAGTTAAAGCCACAGCTGCGCCTGCAGGAGCACCGCCACAACCTCAGGACCTTGAGTTT
ACCAAGTTACCAAATGGCTTGGTGATTGCTTCTTTGGAAAACTATTCTCCTGTATCAAGA
ATTGGTTTGTTCATTAAAGCAGGCAGTAGATATGAGGACTTCAGCAATTTAGGAACCACC
CATTTGCTGCGTCTTACATCCAGTCTGACGACAAAAGGAGCTTCATCTTTCAAGATAACC
CGTGGAATTGAAGCAGTTGGTGGCAAATTAAGTGTGACCGCAACAAGGGAAAACATGGCT
TATACTGTGGAATGCCTGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTC
ACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTTCAGCCTCAGCTAAAGATT
GACAAAGCTGTGGCCTTTCAGAATCCGCAGACTCATGTCATTGAAAATTTGCATGCAGCA
GCTTACCAGAATGCCTTGGCTAATCCCTTGTATTGTCCTGACTATAGGATTGGAAAAGTG
ACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTG
ATTGGACTTGGTGTGAGTCATCCTGTTCTAAAGCAAGTTGCTGAACAGTTTCTCAACATG
AGGGGTGGGCTTGGTTTATCTGGTGCAAAGGCCAACTACCGTGGAGGTGAAATCCGAGAA
CAGAATGGAGACAGTCTTGTCCATGCTGCTTTTGTAGCAGAAAGTGCTGTCGCGGGAAGT
GCAGAGGCAAATGCATTTAGTGTTCTTCAGCATGTCCTCGGTGCTGGGCCACATGTCAAG
AGGGGCAGCAACACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCAACTCAGCAGCCA
TTTGATGTTTCTGCATTTAATGCCAGTTACTCAGATTCTGGACTCTTTGGGATTTATACT
ATCTCCCAGGCCACAGCTGCTGGAGATGTTATCAAGGCTGCCTATAATCAAGTAAAAAGA
ATAGCTCAAGGAAACCTTTCCAACACAGATGTCCAAGCTGCCAAGAACAAGCTGAAAGCT
GGATACCTAATGTCAGTGGAGTCTTCTGAGTGTTTCCTGGAAGAAGTCGGGTCCCAGGCT
CTAGTTGCTGGTTCTTACATGCCACCATCCACAGTCCTTCAGCAGATTGATTCAGTGGCT
AATGCTGATATCATAAATGCGGCAAAGAAGTTTGTTTCTGGCCAGAAGTCAATGGCAGCA
AGTGGAAATTTGGGACATACACCTTTTGTTGATGAGTTGTAA
PF00675
Peptidase_M16
PF05193
Peptidase_M16_C
function
hydrolase activity
function
peptidase activity
function
endopeptidase activity
function
metalloendopeptidase activity
function
catalytic activity
process
metabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
BE0003856
Cytochrome b-c1 complex subunit 6, mitochondrial
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit 6, mitochondrial
Involved in ubiquinol-cytochrome-c reductase activity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1
UQCRH
1p34.1
Mitochondrion inner membrane
None
4.1
10738.7
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:12590
GeneCards
UQCRH
GenBank Gene Database
M36647
GenBank Protein Database
188565
UniProtKB
P07919
UniProt Accession
QCR6_HUMAN
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
>Cytochrome b-c1 complex subunit 6, mitochondrial
MGLEDEQKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSR
SHTEEDCTEELFDFLHARDHCVAHKLFNNLK
>276 bp
ATGGGACTGGAGGACGAGCAAAAGATGCTTACCGAATCCGGAGATCCTGAGGAGGAGGAA
GAGGAAGAGGAGGAATTAGTGGATCCCCTAACAACAGTGAGAGAGCAATGCGAGCAGTTG
GAGAAATGTGTAAAGGCCCGGGAGCGGCTAGAGCTCTGTGATGAGCGTGATTCCTCTCGA
TCACATACAGAAGAGGATTGCACGGAGGAGCTCTTTGACTTCTTGCATGCGAGGGACCAT
TGCGTGGCCCACAAACTCTTTAACAACTTGAAATAA
PF02320
UCR_hinge
function
transporter activity
function
ion transporter activity
function
cation transporter activity
function
monovalent inorganic cation transporter activity
function
hydrogen ion transporter activity
function
ubiquinol-cytochrome-c reductase activity
process
cellular metabolism
process
mitochondrial electron transport, ubiquinol to cytochrome c
process
generation of precursor metabolites and energy
process
electron transport
process
ATP synthesis coupled electron transport
process
physiological process
process
ATP synthesis coupled electron transport (sensu Eukaryota)
process
metabolism
BE0003857
Cytochrome b-c1 complex subunit 8
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit 8
Involved in ubiquinol-cytochrome-c reductase activity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone
UQCRQ
5q31.1
Mitochondrion inner membrane
None
10.5
9906.3
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:29594
GeneCards
UQCRQ
GenBank Gene Database
D50369
GenBank Protein Database
2605590
UniProtKB
O14949
UniProt Accession
QCR8_HUMAN
Complex III subunit 8
Complex III subunit VIII
Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
>Cytochrome b-c1 complex subunit 8
MGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIY
TWGTEEFERSKRKNPAAYENDK
>282 bp
ATGGGCCGCGAGTTTGGGAATCTGACGCGGATGCGGCATGTGATCAGCTACAGCTTGTCA
CCGTTCGAGCAGCGCGCCTATCCGCACGTCTTCACTAAAGGAATCCCCAATGTTCTGCGC
CGCATTCGGGAGTCTTTCTTTCGCGTGGTGCCGCAGTTTGTAGTGTTTTATCTTATCTAC
ACATGGGGGACTGAAGAGTTCGAGAGATCCAAGAGGAGGATCCAGCTGCCTATGAAAATG
ACAAATGAGCAACGCATCCGGATGACGGTTCCCTGTCTCTGA
PF02939
UcrQ
function
transporter activity
function
ion transporter activity
function
cation transporter activity
function
monovalent inorganic cation transporter activity
function
hydrogen ion transporter activity
function
ubiquinol-cytochrome-c reductase activity
process
metabolism
process
cellular metabolism
process
generation of precursor metabolites and energy
process
electron transport
process
physiological process
BE0003858
Cytochrome b-c1 complex subunit Rieske, mitochondrial
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit Rieske, mitochondrial
Energy production and conversion
The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex (By similarity)
UQCRFS1
19q12-q13.1
Mitochondrion inner membrane
None
8.46
29667.7
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:12587
GeneCards
UQCRFS1
GenBank Gene Database
AK291134
GenBank Protein Database
158255704
UniProtKB
P47985
UniProt Accession
UCRI_HUMAN
Complex III subunit 5
Complex III subunit IX
Cytochrome b-c1 complex subunit 11
Rieske iron-sulfur protein
RISP
Ubiquinol-cytochrome c reductase 8 kDa protein
Ubiquinol-cytochrome c reductase iron-sulfur subunit
>Cytochrome b-c1 complex subunit Rieske, mitochondrial
MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAV
RRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGV
TTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRT
QKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHG
SHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG
>825 bp
ATGTTGTCGGTAGCAGCCCGCTCGGGCCCGTTCGCGCCCGTCCTGTCGGCCACGTCCCGC
GGGGTGGCGGGCGCGCTGCGGCCCTTGGTGCAGGCCACGGTGCCCGCCACCCCGGAGCAG
CCTGTGTTGGACCTGAAGCGGCCCTTCCTCAGCCGGGAGTCGCTGAGCGGCCAGGCCGTG
CGCCGGCCTTTGGTCGCCTCCGTGGGCCTCAATGTCCCTGCTTCTGTTTGTTATTCCCAC
ACAGACATCAAGGTGCCTGACTTCTCTGAATACCGCCGCCTTGAAGTTTTAGATAGTACG
AAGTCTTCAAGAGAAAGCAGCGAGGCTAGGAAAGGTTTCTCCTATTTGGTAACTGGAGTA
ACTACTGTGGGTGTCGCATATGCTGCCAAGAATGCCGTCACCCAGTTCGTTTCCAGCATG
AGTGCTTCTGCTGATGTGTTGGCCCTGGCGAAAATCGAAATCAAGTTATCCGATATTCCA
GAAGGCAAGAACATGGCTTTCAAATGGAGAGGCAAACCCCTGTTTGTGCGTCATAGAACC
CAGAAGGAAATTGAGCAGGAAGCTGCAGTTGAATTATCACAGTTGAGGGACCCACAGCAT
GATCTAGATCGAGTAAAGAAACCTGAATGGGTTATCCTGATAGGTGTTTGCACTCATCTT
GGCTGTGTACCCATTGCAAATGCAGGAGATTTTGGTGGTTATTACTGCCCTTGCCATGGG
TCACACTATGATGCATCTGGCAGGATCAGATTGGGTCCTGCTCCTCTCAACCTTGAAGTC
CCCACGTATGAGTTCACCAGTGACGATATGGTGATTGTTGGTTAA
PF00355
Rieske
PF09165
Ubiq-Cytc-red_N
PF02921
UCR_TM
component
ubiquinol-cytochrome-c reductase complex
component
cell
component
membrane
component
protein complex
function
hydrogen ion transporter activity
function
ubiquinol-cytochrome-c reductase activity
function
transporter activity
function
ion transporter activity
function
cation transporter activity
function
monovalent inorganic cation transporter activity
process
cellular metabolism
process
generation of precursor metabolites and energy
process
electron transport
process
physiological process
process
metabolism
BE0003859
Cytochrome b-c1 complex subunit 10
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit 10
Involved in electron carrier activity
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor
UQCR11
Mitochondrion inner membrane
16-36
10.35
6569.7
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:30862
GeneCards
UQCR
GenBank Gene Database
D55636
GenBank Protein Database
2317646
UniProtKB
O14957
UniProt Accession
QCR10_HUMAN
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
>Cytochrome b-c1 complex subunit 10
MVTRFLGPRYRELVKNWVPTAYTWGAVGAVGLVWATDWRLILDWVPYINGKFKKDN
>171 bp
ATGGTGACCCGGTTCCTGGGCCCACGCTACCGGGAGCTGGTCAAGAACTGGGTCCCGACG
GCCTACACATGGGGCGCTGTGGGCGCCGTGGGGCTGGTGTGGGCCACCGATTGGCGGCTG
ATCCTGGACTGGGTACCTTACATCAATGGCAAGTTTAAGAAGGATAATTAA
PF08997
UCR_6-4kD
BE0003860
Cytochrome b-c1 complex subunit 7
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit 7
Involved in ubiquinol-cytochrome-c reductase activity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping
UQCRB
8q22
Mitochondrion inner membrane
None
9.23
13530.3
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:12582
GeneCards
UQCRB
GenBank Gene Database
X13585
GenBank Protein Database
37580
UniProtKB
P14927
UniProt Accession
QCR7_HUMAN
Complex III subunit 7
Complex III subunit VII
QP-C
Ubiquinol-cytochrome c reductase complex 14 kDa protein
>Cytochrome b-c1 complex subunit 7
MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRM
FRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK
>336 bp
ATGGCTGGTAAGCAGGCCGTTTCAGCATCAGGCAAGTGGCTGGATGGTATTCGAAAATGG
TATTACAATGCTGCAGGATTCAATAAACTGGGGTTAATGCGAGATGATACAATATACGAG
GATGAAGATGTAAAAGAAGCCATAAGAAGACTTCCTGAGAACCTTTATAATGACAGGATG
TTTCGCATTAAGAGGGCACTGGACCTGAACTTGAAGCATCAGATCTTGCCTAAAGAGCAG
TGGACCAAATATGAAGAGGAAAATTTCTACCTTGAACCGTATCTGAAAGAGGTTATTCGG
GAAAGAAAAGAAAGAGAAGAATGGGCAAAGAAGTAA
PF02271
UCR_14kD
function
ubiquinol-cytochrome-c reductase activity
function
transporter activity
function
ion transporter activity
function
cation transporter activity
function
monovalent inorganic cation transporter activity
function
hydrogen ion transporter activity
process
metabolism
process
cellular metabolism
process
mitochondrial electron transport, ubiquinol to cytochrome c
process
generation of precursor metabolites and energy
process
electron transport
process
ATP synthesis coupled electron transport
process
physiological process
process
ATP synthesis coupled electron transport (sensu Eukaryota)
BE0003861
Cytochrome b-c1 complex subunit 9
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Cytochrome b-c1 complex subunit 9
Involved in ubiquinol-cytochrome-c reductase activity
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity)
UQCR10
22cen-q12.3
Mitochondrion inner membrane (By similarity)
None
9.97
7308.4
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:30863
GeneCards
UQCR10
GenBank Gene Database
AB028598
GenBank Protein Database
12081913
UniProtKB
Q9UDW1
UniProt Accession
QCR9_HUMAN
Complex III subunit 9
Complex III subunit X
Cytochrome c1 non-heme 7 kDa protein
Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
>Cytochrome b-c1 complex subunit 9
MAAATLTSKLYSLLFRRTSTFALTIIVGVMFFERAFDQGADAIYDHINEGKLWKHIKHKY
ENK
>192 bp
ATGGCGGCCGCGACGTTGACTTCGAAATTGTACTCCCTGCTGTTCCGCAGGACCTCCACC
TTCGCCCTCACCATCATCGTGGGCGTCATGTTCTTCGAGCGCGCCTTCGATCAAGGCGCG
GACGCTATCTACGACCACATCAACGAGGGGAAGCTGTGGAAACACATCAAGCACAAGTAT
GAGAACAAGTAG
PF05365
UCR_UQCRX_QCR9
component
envelope
component
organelle envelope
component
mitochondrial envelope
function
transporter activity
function
ubiquinol-cytochrome-c reductase activity
function
ion transporter activity
function
cation transporter activity
function
monovalent inorganic cation transporter activity
function
hydrogen ion transporter activity
process
cellular metabolism
process
generation of precursor metabolites and energy
process
electron transport
process
mitochondrial electron transport, ubiquinol to cytochrome c
process
ATP synthesis coupled electron transport
process
physiological process
process
ATP synthesis coupled electron transport (sensu Eukaryota)
process
metabolism
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All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt
The resource does not appear as an object