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Predicate	Value (sorted: none)
ns1:description	" experimental This compound belongs to the furopyrroles. These are organic polycyclic compounds containing a furan ring fused to a pyrrole ring. Furopyrroles Organic Compounds Heterocyclic Compounds Furopyrroles Beta-hydroxy Aldehydes Pyrrolidones Oxolanes Tetrahydrofurans Pyrroles Furans Lactams Secondary Alcohols Secondary Carboxylic Acid Amides Polyamines Enolates Carboxylic Acids Ethers beta-hydroxy aldehyde pyrrolidone oxolane pyrrole furan tetrahydrofuran pyrrolidine secondary alcohol secondary carboxylic acid amide carboxamide group lactam polyamine carboxylic acid derivative enolate carboxylic acid ether alcohol organonitrogen compound aldehyde logP 0.67 ALOGPS logS -2.1 ALOGPS Water Solubility 2.09e+00 g/l ALOGPS logP 0.22 ChemAxon IUPAC Name (3aR,6R,6aS)-6-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-6a-methyl-4-oxo-hexahydro-2H-furo[2,3-c]pyrrole-6-carbaldehyde ChemAxon Traditional IUPAC Name (3aR,6R,6aS)-6-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-6a-methyl-4-oxo-tetrahydrofuro[2,3-c]pyrrole-6-carbaldehyde ChemAxon Molecular Weight 279.3315 ChemAxon Monoisotopic Weight 279.147058165 ChemAxon SMILES [H][C@](O)([C@@]1([H])CCCC=C1)[C@]1(NC(=O)[C@]2([H])CCO[C@]12C)C=O ChemAxon Molecular Formula C15H21NO4 ChemAxon InChI InChI=1S/C15H21NO4/c1-14-11(7-8-20-14)13(19)16-15(14,9-17)12(18)10-5-3-2-4-6-10/h3,5,9-12,18H,2,4,6-8H2,1H3,(H,16,19)/t10-,11+,12+,14+,15-/m1/s1 ChemAxon InChIKey InChIKey=YVABESCRHMBHJD-FUQNVFFISA-N ChemAxon Polar Surface Area (PSA) 75.63 ChemAxon Refractivity 73.39 ChemAxon Polarizability 28.77 ChemAxon Rotatable Bond Count 3 ChemAxon H Bond Acceptor Count 4 ChemAxon H Bond Donor Count 2 ChemAxon pKa (strongest acidic) 10.76 ChemAxon pKa (strongest basic) -2.1 ChemAxon Physiological Charge 0 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon PubChem Compound 11840981 PubChem Substance 99444986 ChemSpider 10015482 PDB SA1 BE0003910 Proteasome subunit alpha type-1 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit alpha type-1 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMA1 11p15.1 Cytoplasm. Nucleus None 6.6 29555.3 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9530 GeneCards PSMA1 GenBank Gene Database D00759 GenBank Protein Database 220022 UniProtKB P25786 UniProt Accession PSA1_HUMAN 30 kDa prosomal protein Macropain subunit C2 Multicatalytic endopeptidase complex subunit C2 PROS-30 Proteasome component C2 Proteasome nu chain >Proteasome subunit alpha type-1 MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP QRKAQPAQPADEPAEKADEPMEH >792 bp ATGTTTCGAAATCAGTATGACAATGATGTCACTGTTTGGAGCCCCCAGGGCAGGATTCAT CAAATTGAATATGCAATGGAAGCTGTTAAACAAGGTTCAGCCACAGTTGGTCTGAAATCA AAAACTCATGCAGTTTTGGTTGCATTGAAAAGGGCGCAATCAGAGCTTGCAGCTCATCAG AAAAAAATTCTCCATGTTGACAACCATATTGGTATCTCAATTGCGGGGCTTACTGCTGAT GCTAGACTGTTATGTAATTTTATGCGTCAGGAGTGTTTGGATTCCAGATTTGTATTCGAT AGACCACTGCCTGTGTCTCGTCTTGTATCTCTAATTGGAAGCAAGACCCAGATACCAACA CAACGATATGGCCGGAGACCATATGGTGTTGGTCTCCTTATTGCTGGTTATGATGATATG GGCCCTCACATTTTCCAAACCTGTCCATCTGCTAACTATTTTGACTGCAGAGCCATGTCC ATTGGAGCCCGTTCCCAATCAGCTCGTACTTACTTGGAGAGACATATGTCTGAATTTATG GAGTGTAATTTAAATGAACTAGTTAAACATGGTCTGCGTGCCTTAAGAGAGACGCTTCCT GCAGAACAGGACCTGACTACAAAGAATGTTTCCATTGGAATTGTTGGTAAAGACTTGGAG TTTACAATCTATGATGATGATGATGTGTCTCCATTCCTGGAAGGTCTTGAAGAAAGACCA CAGAGAAAGGCACAGCCTGCTCAACCTGCTGATGAACCTGCAGAAAAGGCTGATGAACCA ATGGAACATTAA PF00227 Proteasome PF10584 Proteasome_A_N component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism BE0003911 Proteasome subunit alpha type-2 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit alpha type-2 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation PSMA2 7p13 Cytoplasm. Nucleus None 7.55 25898.4 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9531 GeneCards PSMA2 GenBank Gene Database D00760 GenBank Protein Database 220024 UniProtKB P25787 UniProt Accession PSA2_HUMAN Macropain subunit C3 Multicatalytic endopeptidase complex subunit C3 Proteasome component C3 >Proteasome subunit alpha type-2 MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA >705 bp ATGGCGGAGCGCGGGTACAGCTTTTCGCTGACTACATTCAGCCCGTCTGGTAAACTTGTC CAGATTGAATATGCTTTGGCTGCTGTAGCTGGAGGAGCCCCGTCCGTGGGAATTAAAGCT GCAAATGGTGTGGTATTAGCAACTGAGAAAAAACAGAAATCCATTCTGTATGATGAGCGA AGTGTACACAAAGTAGAACCAATTACCAAGCATATAGGTTTGGTGTACAGTGGCATGGGC CCCGATTACAGAGTGCTTGTGCACAGAGCTCGAAAACTAGCTCAACAATACTATCTTGTG TACCAAGAACCCATTCCTACAGCTCAGCTGGTACAGAGAGTAGCTTCTGTGATGCAAGAA TATACTCAGTCAGGTGGTGTTCGTCCATTTGGAGTTTCTTTACTTATTTGTGGTTGGAAT GAGGGACGACCATATTTATTTCAGTCAGATCCATCTGGAGCTTACTTTGCCTGGAAAGCT ACAGCAATGGGAAAGAACTATGTGAATGGGAAGACTTTCCTTGAGAAAAGATATAATGAA GATCTGGAACTTGAAGATGCCATTCATACAGCCATCTTAACCCTAAAGGAAAGCTTTGAA GGGCAAATGACAGAGGATAACATAGAAGTTGGAATCTGCAATGAAGCTGGATTTAGGAGG CTTACTCCAACTGAAGTTAAGGATTACTTGGCTGCCATAGCATAA PF00227 Proteasome PF10584 Proteasome_A_N component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function hydrolase activity function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism BE0003912 Proteasome subunit alpha type-3 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit alpha type-3 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMA3 14q23 Cytoplasm. Nucleus None 4.97 28433.0 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9532 GeneCards PSMA3 GenBank Gene Database D00762 GenBank Protein Database 220028 UniProtKB P25788 UniProt Accession PSA3_HUMAN Macropain subunit C8 Multicatalytic endopeptidase complex subunit C8 Proteasome component C8 >Proteasome subunit alpha type-3 MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA KESLKEEDESDDDNM >768 bp ATGAGCTCAATCGGCACTGGGTATGACCTGTCAGCCTCTACATTCTCTCCTGACGGAAGA GTTTTTCAAGTTGAATATGCTATGAAGGCTGTGGAAAATAGTAGTACAGCTATTGGAATC AGATGCAAAGATGGTGTTGTCTTTGGGGTAGAAAAATTAGTCCTTTCTAAACTTTATGAA GAAGGTTCCAACAAAAGACTTTTTAATGTTGATCGGCATGTTGGAATGGCAGTAGCAGGT TTGTTGGCAGATGCTCGTTCTTTAGCAGACATAGCAAGAGAAGAAGCTTCCAACTTCAGA TCTAACTTTGGCTACAACATTCCACTAAAACATCTTGCAGACAGAGTGGCCATGTATGTG CATGCATATACACTCTACAGTGCTGTTAGACCTTTTGGCTGCAGTTTCATGTTAGGGTCT TACAGTGTGAATGACGGTGCGCAACTCTACATGATTGACCCATCAGGTGTTTCATACGGT TATTGGGGCTGTGCCATCGGCAAAGCCAGGCAAGCTGCAAAGACGGAAATAGAGAAGCTT CAGATGAAAGAAATGACCTGCCGTGATATCGTTAAAGAAGTTGCAAAAATAATTTACATA GTACATGACGAAGTTAAGGATAAAGCTTTTGAACTAGAACTCAGCTGGGTTGGTGAATTA ACTAATGGAAGACATGAAATTGTTCCAAAAGATATAAGAGAAGAAGCAGAGAAATATGCT AAGGAATCTCTGAAGGAAGAAGATGAATCAGATGATGATAATATGTAA PF00227 Proteasome PF10584 Proteasome_A_N component protein complex component proteasome core complex (sensu Eukaryota) component proteasome complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism BE0003913 Proteasome subunit alpha type-4 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit alpha type-4 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMA4 15q25.1 Cytoplasm. Nucleus None 7.86 29483.6 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9533 GeneCards PSMA4 GenBank Gene Database D00763 GenBank Protein Database 220030 UniProtKB P25789 UniProt Accession PSA4_HUMAN Macropain subunit C9 Multicatalytic endopeptidase complex subunit C9 Proteasome component C9 Proteasome subunit L >Proteasome subunit alpha type-4 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH EEEEAKAEREKKEKEQKEKDK >786 bp ATGTCTCGAAGATATGACTCCAGGACCACTATATTTTCTCCAGAAGGTCGCTTATACCAA GTTGAATATGCCATGGAAGCTATTGGACATGCAGGCACCTGTTTGGGAATTTTAGCAAAT GATGGTGTTTTGCTTGCAGCAGAGAGACGCAACATCCACAAGCTTCTTGATGAAGTCTTT TTTTCTGAAAAAATTTATAAACTCAATGAGGACATGGCTTGCAGTGTGGCAGGCATAACT TCTGATGCTAATGTTCTGACTAATGAACTAAGGCTCATTGCTCAAAGGTATTTATTACAG TATCAGGAGCCAATACCTTGTGAGCAGTTGGTTACAGCACTGTGTGATATCAAACAAGCT TATACACAATTTGGAGGAAAACGTCCCTTTGGTGTTTCATTGCTGTACATTGGCTGGGAT AAGCACTATGGCTTTCAGCTCTATCAGAGTGACCCTAGTGGAAATTACGGGGGATGGAAG GCCACATGCATTGGAAATAATAGCGCTGCAGCTGTGTCAATGTTGAAACAAGACTATAAA GAAGGAGAAATGACCTTGAAGTCAGCACTTGCTTTAGCTATCAAAGTACTAAATAAGACC ATGGATGTTAGTAAACTCTCTGCTGAAAAAGTGGAAATTGCAACACTAACAAGAGAGAAT GGAAAGACAGTAATCAGAGTTCTCAAACAAAAAGAAGTGGAGCAGTTGATCAAAAAACAT GAGGAAGAAGAAGCCAAAGCTGAGCGTGAGAAGAAAGAAAAAGAACAGAAAGAAAAGGAT AAATAG PF00227 Proteasome PF10584 Proteasome_A_N component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism BE0003914 Proteasome subunit alpha type-5 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit alpha type-5 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMA5 1p13 Cytoplasm. Nucleus None 4.45 26410.8 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9534 GeneCards PSMA5 GenBank Gene Database X61970 GenBank Protein Database 296740 UniProtKB P28066 UniProt Accession PSA5_HUMAN Macropain zeta chain Multicatalytic endopeptidase complex zeta chain Proteasome zeta chain >Proteasome subunit alpha type-5 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD I >726 bp ATGTTTCTTACCCGGTCTGAGTACGACAGGGGCGTGAATACTTTTTCTCCCGAAGGAAGA TTATTTCAAGTGGAATATGACATTGAGGCTATCAAGCTTGGTTCTACAGCCATTGGGATC CAGACATCAGAGGGTGTGTGCCTAGCTGTGGAGAAGAGAATTACTTCCCCACTGATGGAG CCCAGCAGCATTGAGAAAATTGTAGAGATTGATGCTCACATAGGTTGTGCCATGAGTGGG CTAATTGCTGATGCTAAGACTTTAATTGATAAAGCCAGAGTGGAGACACAGAACCACTGG TTCACCTACAATGAGACAATGACAGTGGAGAGTGTGACCCAAGCTGTGTCCAATCTGGCT TTGCAGTTTGGAGAAGAAGATGCAGATCCAGGTGCCATGTCTCGTCCCTTTGGAGTAGCA TTATTATTTGGAGGAGTTGATGAGAAAGGACCCCAGCTGTTTCATATGGACCCATCTGGG ACCTTTGTACAGTGTGATGCTCGAGCAATTGGCTCTGCTTCAGAGGGTGCCCAGAGCTCC TTGCAAGAACTTTACCACAAGTCTATGACTTTGAAAGAAGCCATCAAGTCTTCACTCATC ATCCTCAAACAAGTAATGGAGGAGAAGCTGAATGCAACAAACATTGAGCTAGCCACAGTG CAGCCTGGCCAGAATTTCCACATGTTCACAAAGGAAGAACTTGAAGAGGTTATCAAGGAC ATTTAA PF00227 Proteasome PF10584 Proteasome_A_N component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function hydrolase activity function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism BE0003915 Proteasome subunit alpha type-6 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit alpha type-6 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMA6 14q13 Cytoplasm. Nucleus None 6.74 27399.2 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9535 GeneCards PSMA6 GenBank Gene Database X59417 GenBank Protein Database 35682 UniProtKB P60900 UniProt Accession PSA6_HUMAN 27 kDa prosomal protein Macropain iota chain Multicatalytic endopeptidase complex iota chain p27K PROS-27 Proteasome iota chain >Proteasome subunit alpha type-6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV ALAERD >741 bp ATGTCCCGTGGTTCCAGCGCCGGTTTTGACCGCCACATTACCATTTTTTCACCCGAGGGT CGGCTCTACCAAGTAGAATATGCTTTTAAGGCTATTAACCAGGGTGGCCTTACATCAGTA GCTGTCAGAGGGAAAGACTGTGCAGTAATTGTCACACAGAAGAAAGTACCTGACAAATTA TTGGATTCCAGCACAGTGACTCACTTATTCAAGATAACTGAAAACATTGGTTGTGTGATG ACCGGAATGACAGCTGACAGCAGATCCCAGGTACAGAGGGCACGCTATGAGGCAGCTAAC TGGAAATACAAGTATGGCTATGAGATTCCTGTGGACATGCTGTGTAAAAGAATTGCCGAT ATTTCTCAGGTCTACACACAGAATGCTGAAATGAGGCCTCTTGGTTGTTGTATGATTTTA ATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTAC TGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAA AAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACA TGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTG ACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTT GCTCTAGCAGAGAGAGACTAA PF00227 Proteasome PF10584 Proteasome_A_N component protein complex component proteasome core complex (sensu Eukaryota) component proteasome complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism BE0003916 Proteasome subunit alpha type-7 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit alpha type-7 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMA7 20q13.33 Cytoplasm. Nucleus None 8.73 27886.6 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9536 GeneCards PSMA7 GenBank Gene Database AF022815 GenBank Protein Database 2555136 UniProtKB O14818 UniProt Accession PSA7_HUMAN Proteasome subunit RC6-1 Proteasome subunit XAPC7 >Proteasome subunit alpha type-7 MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE KKKQKKAS >747 bp ATGAGCTACGACCGCGCCATCACCGTCTTCTCGCCCGACGGCCACCTCTTCCAAGTGGAG TACGCGCAGGAGGCCGTCAAGAAGGGCTCGACCGCGGTTGGTGTTCGAGGAAGAGACATT GTTGTTCTTGGTGTGGAGAAGAAGTCAGTGGCCAAACTGCAGGATGAAAGAACAGTGCGG AAGATCTGTGCTTTGGATGACAACGTCTGCATGGCCTTTGCAGGCCTCACCGCCGATGCA AGGATAGTCATCAACAGGGCCCGGGTGGAGTGCCAGAGCCACCGGCTGACTGTAGAGGAC CCGGTCACTGTGGAGTACATCACCCGCTACATCGCCAGTCTGAAGCAGCGTTATACGCAG AGCAATGGGCGCAGGCCGTTTGGCATCTCTGCCCTCATCGTGGGTTTCGACTTTGATGGC ACTCCTAGGCTCTATCAGACTGACCCCTCGGGCACATACCATGCCTGGAAGGCCAATGCC ATAGGCCGGGGTGCCAAGTCAGTGCGCGAGTTCCTGGAGAAGAACTATACTGACGAAGCC ATTGAAACAGATGATCTGACCATTAAGCTGGTGATCAAGGCACTCCTGGAAGTGGTTCAG TCAGGTGGCAAAAACATTGAACTTGCTGTCATGAGGCGAGATCAATCCCTCAAGATTTTA AATCCTGAAGAAATTGAGAAGTATGTTGCTGAAATTGAAAAAGAAAAAGAAGAAAACGAA AAGAAGAAACAAAAGAAAGCATCATGA PF00227 Proteasome PF10584 Proteasome_A_N component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism BE0002347 Proteasome subunit beta type-1 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit beta type-1 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMB1 6q27 Cytoplasm None 8.29 26490.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:9537 GenAtlas PSMB1 GeneCards PSMB1 GenBank Gene Database D00761 GenBank Protein Database 220026 UniProtKB P20618 UniProt Accession PSB1_HUMAN EC 3.4.25.1 Macropain subunit C5 Multicatalytic endopeptidase complex subunit C5 Proteasome component C5 Proteasome gamma chain Proteasome subunit beta type 1 precursor >Proteasome subunit beta type 1 MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK D >726 bp ATGTTGTCCTCTACAGCCATGTATTCGGCTCCTGGCAGAGACTTGGGGATGGAACCGCAC AGAGCCGCGGGCCCTTTGCAGCTGCGATTTTCGCCCTACGTTTTCAACGGAGGTACTATA CTGGCAATTGCTGGAGAAGATTTTGCAATTGTTGCTTCTGATACTCGATTGAGTGAAGGG TTTTCAATTCATACGCGGGATAGCCCCAAATGTTACAAATTAACAGACAAAACAGTCATT GGATGCAGCGGTTTTCATGGAGACTGTCTTACGCTGACAAAGATTATTGAAGCAAGACTA AAGATGTATAAGCATTCCAATAATAAGGCCATGACTACGGGGGCAATTGCTGCAATGCTG TCTACAATCCTGTATTCAAGGCGCTTCTTTCCATACTATGTTTACAACATCATCGGTGGA CTTGATGAAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTTACCAGAGA GACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAG GTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATG CGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTGGGGACGCA CTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAG GACTGA PF00227 Proteasome component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function hydrolase activity function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism BE0002349 Proteasome subunit beta type-2 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit beta type-2 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity PSMB2 1p34.2 Cytoplasm None 7.04 22837.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:9539 GenAtlas PSMB2 GeneCards PSMB2 GenBank Gene Database D26599 GenBank Protein Database 565649 UniProtKB P49721 UniProt Accession PSB2_HUMAN EC 3.4.25.1 Macropain subunit C7-I Multicatalytic endopeptidase complex subunit C7-I Proteasome component C7- I >Proteasome subunit beta type 2 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV RIIDKNGIHDLDNISFPKQGS >606 bp ATGGAGTACCTCATCGGTATCCAAGGCCCCGACTATGTTCTTGTCGCCTCCGACCGGGTG GCCGCCAGCAATATTGTCCAGATGAAGGACGATCATGACAAGATGTTTAAGATGAGTGAA AAGATATTACTCCTGTGTGTTGGAGAGGCTGGAGACACTGTACAGTTTGCAGAATATATT CAGAAAAACGTGCAACTTTATAAGATGCGAAATGGATATGAATTGTCTCCCACGGCAGCA GCTAACTTCACACGCCGAAACCTGGCTGACTGTCTTCGGAGTCGGACCCCATATCATGTG AACCTCCTCCTGGCTGGCTATGATGAGCATGAAGGGCCAGCGCTGTATTACATGGACTAC CTGGCAGCCTTGGCCAAGGCCCCTTTTGCAGCCCACGGCTATGGTGCCTTCCTGACTCTC AGTATCCTCGACCGATACTACACACCGACTATCTCACGTGAGAGGGCAGTGGAACTCCTT AGGAAATGTCTGGAGGAGCTCCAGAAACGCTTCATCCTGAATCTGCCAACCTTCAGTGTT CGAATCATTGACAAAAATGGCATCCATGACCTGGATAACATTTCCTTCCCCAAACAGGGC TCCTAA PF00227 Proteasome component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism BE0003917 Proteasome subunit beta type-3 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit beta type-3 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMB3 17q12 Cytoplasm. Nucleus None 6.51 22948.7 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9540 GeneCards PSMB3 GenBank Gene Database D26598 GenBank Protein Database 565647 UniProtKB P49720 UniProt Accession PSB3_HUMAN Proteasome chain 13 Proteasome component C10-II Proteasome theta chain >Proteasome subunit beta type-3 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV SGMGVIVHIIEKDKITTRTLKARMD >618 bp ATGTCTATTATGTCCTATAACGGAGGGGCCGTCATGGCCATGAAGGGGAAGAACTGTGTG GCCATCGCTGCAGACAGGCGCTTCGGGATCCAGGCCCAGTTGGTGACCACGGACTTCCAG AAGATCTTTCCCATGGGTGACCGGCTGTACATCGGTCTGGCCGGGCTCGCCACTGACGTC CAGACAGTTGCCCAGCGCCTCAAGTTCCGGCTGAACCTGTATGAGTTGAAGGAAGGTCGG CAGATCAAACCTTATACCCTCATGAGCATGGTGGCCAACCTCTTGTATGAGAAACGGTTT GGCCCTTACTACACTGAGCCAGTCATTGCCGGGTTGGACCCGAAGACCTTTAAGCCCTTC ATTTGCTCTCTAGACCTCATCGGCTGCCCCATGGTGACTGATGACTTTGTGGTCAGTGGC ACCTGCGCCGAACAAATGTACGGAATGTGTGAGTCCCTCTGGGAGCCCAACATGGATCCG GATCACCTGTTTGAAACCATCTCCCAAGCCATGCTGAATGCTGTGGACCGGGATGCAGTG TCAGGCATGGGAGTCATTGTCCACATCATCGAGAAGGACAAAATCACCACCAGGACACTG AAGGCCCGAATGGACTAA PF00227 Proteasome component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism BE0003918 Proteasome subunit beta type-4 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit beta type-4 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMB4 1q21 Cytoplasm (By similarity). Nucleus (By similarity) None 5.77 29204.0 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9541 GeneCards PSMB4 GenBank Gene Database D26600 GenBank Protein Database 565651 UniProtKB P28070 UniProt Accession PSB4_HUMAN HsBPROS26 HSN3 Macropain beta chain Multicatalytic endopeptidase complex beta chain Proteasome beta chain Proteasome chain 3 >Proteasome subunit beta type-4 MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK GVEIEGPLSTETNWDIAHMISGFE >795 bp ATGGAAGCGTTTTTGGGGTCGCGGTCCGGACTTTGGGCGGGGGGTCCGGCCCCAGGACAG TTTTACCGCATTCCGTCCACTCCCGATTCCTTCATGGATCCGGCGTCTGCACTTTACAGA GGTCCAATCACGCGGACCCAGAACCCCATGGTGACCGGGACCTCAGTCCTCGGCGTTAAG TTCGAGGGCGGAGTGGTGATTGCCGCAGACATGCTGGGATCCTACGGCTCCTTGGCTCGT TTCCGCAACATCTCTCGCATTATGCGAGTCAACAACAGTACCATGCTGGGTGCCTCTGGC GACTACGCTGATTTCCAGTATTTGAAGCAAGTTCTCGGCCAGATGGTGATTGATGAGGAG CTTCTGGGAGATGGACACAGCTATAGTCCTAGAGCTATTCATTCATGGCTGACCAGGGCC ATGTACAGCCGGCGCTCGAAGATGAACCCTTTGTGGAACACCATGGTCATCGGAGGCTAT GCTGATGGAGAGAGCTTCCTCGGTTATGTGGACATGCTTGGTGTAGCCTATGAAGCCCCT TCGCTGGCCACTGGTTATGGTGCATACTTGGCTCAGCCTCTGCTGCGAGAAGTTCTGGAG AAGCAGCCAGTGCTAAGCCAGACCGAGGCCCGCGACTTAGTAGAACGCTGCATGCGAGTG CTGTACTACCGAGATGCCCGTTCTTACAACCGGTTTCAAACCGCCACTGTCACCGAAAAA GGTGTTGAAATAGAGGGACCATTGTCTACAGAGACCAACTGGGATATTGCCCACATGATC AGTGGCTTTGAATGA PF00227 Proteasome component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function hydrolase activity function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism BE0002348 Proteasome subunit beta type-5 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit beta type-5 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens PSMB5 14q11.2 Cytoplasm None 8.68 22897.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:9542 GenAtlas PSMB5 GeneCards PSMB5 GenBank Gene Database D29011 GenBank Protein Database 558526 UniProtKB P28074 UniProt Accession PSB5_HUMAN EC 3.4.25.1 Macropain epsilon chain Multicatalytic endopeptidase complex epsilon chain Proteasome chain 6 Proteasome epsilon chain Proteasome subunit beta type 5 precursor Proteasome subunit MB1 Proteasome subunit X >Proteasome subunit beta type 5 MLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWE RLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDS EGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNL YHVREDGWIRVSSDNVADLHEKYSGSTP >627 bp ATGCTTCATGGAACAACCACCCTGGCCTTCAAGTTCCGCCATGGAGTCATAGTTGCAGCT GACTCCAGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGATAGAG ATCAACCCATACCTGCTAGGCACCATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAA CGGCTGTTGGCTCGGCAATGTCGAATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTA GCAGCTGCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCTGTCC ATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGT GAAGGGAACCGGATTTCAGGGGCCACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATAT GGGGTCATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCC CGTCGAGCCATCTACCAAGCCACCTACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTC TACCACGTGCGGGAGGATGGCTGGATCCGAGTCTCCAGTGACAATGTGGCTGATCTACAT GAGAAGTATAGTGGCTCTACCCCCTGA PF00227 Proteasome component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism BE0003919 Proteasome subunit beta type-6 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit beta type-6 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens PSMB6 17p13 Cytoplasm. Nucleus None 4.54 25357.5 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9543 GeneCards PSMB6 GenBank Gene Database D29012 GenBank Protein Database 558528 UniProtKB P28072 UniProt Accession PSB6_HUMAN Macropain delta chain Multicatalytic endopeptidase complex delta chain Proteasome delta chain Proteasome subunit Y >Proteasome subunit beta type-6 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA >720 bp ATGGCGGCTACCTTACTAGCTGCTCGGGGAGCCGGGCCAGCACCGGCTTGGGGGCCGGAG GCATTCACTCCAGACTGGGAAAGCCGAGAAGTTTCCACTGGGACCACTATCATGGCCGTG CAGTTTGACGGGGGCGTGGTTCTGGGGGCGGACTCCAGAACAACCACTGGGTCCTACATC GCCAATCGAGTGACTGACAAGCTGACACCTATTCACGACCGCATTTTCTGCTGTCGCTCA GGCTCAGCTGCTGATACCCAGGCAGTAGCTGATGCTGTCACCTACCAGCTCGGTTTCCAC AGCATTGAACTGAATGAGCCTCCACTGGTCCACACAGCAGCCAGCCTCTTTAAGGAGATG TGTTACCGATACCGGGAAGACCTGATGGCGGGAATCATCATCGCAGGCTGGGACCCTCAA GAAGGAGGGCAGGGGTACTCAGTGCCTATGGGGGGTATGATGGTAAGGCAGTCCTTTGCC ATTGGAGGCTCCGGGAGCTCCTACATCTATGGCTATGTTGATGCTACCTACCGGGAAGGC ATGACCAAGGAAGAGTGTCTGCAATTCACTGCCAATGCTCTCGCTTTGGCCATGGAGCGG GATGGCTCCAGTGGAGGAGTGATCCGCCTGGCAGCCATTGCAGAGTCAGGGGTAGAGCGG CAAGTACTTTTGGGAGACCAGATACCCAAATTCGCCGTTGCCACTTTACCACCCGCCTGA PF00227 Proteasome component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity function hydrolase activity process proteolysis process physiological process process proteolysis during cellular protein catabolism process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism BE0003920 Proteasome subunit beta type-7 Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Proteasome subunit beta type-7 Posttranslational modification, protein turnover, chaperones The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity PSMB7 9q34.11-q34.12 Cytoplasm. Nucleus None 7.79 29965.2 Human HUGO Gene Nomenclature Committee (HGNC) GNC:9544 GeneCards PSMB7 GenBank Gene Database D38048 GenBank Protein Database 1531533 UniProtKB Q99436 UniProt Accession PSB7_HUMAN Macropain chain Z Multicatalytic endopeptidase complex chain Z Proteasome subunit Z >Proteasome subunit beta type-7 MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS >834 bp ATGGCGGCTGTGTCGGTGTATGCTCCACCAGTTGGAGGCTTCTCTTTTGATAACTGCCGC AGGAATGCCGTCTTGGAAGCCGATTTTGCAAAGAGGGGATACAAGCTTCCAAAGGTCCGG AAAACTGGCACGACCATCGCTGGGGTGGTCTATAAGGATGGCATAGTTCTTGGAGCAGAT ACAAGAGCAACTGAAGGGATGGTTGTTGCTGACAAGAACTGTTCAAAAATACACTTCATA TCTCCTAATATTTATTGTTGTGGTGCTGGGACAGCTGCAGACACAGACATGACAACCCAG CTCATTTCTTCCAACCTGGAGCTCCACTCCCTCTCCACTGGCCGTCTTCCCAGAGTTGTG ACAGCCAATCGGATGCTGAAGCAGATGCTTTTCAGGTATCAAGGTTACATTGGTGCAGCC CTAGTTTTAGGGGGAGTAGATGTTACTGGACCTCACCTCTACAGCATCTATCCTCATGGA TCAACTGATAAGTTGCCTTATGTCACCATGGGTTCTGGCTCCTTGGCAGCAATGGCTGTA TTTGAAGATAAGTTTAGGCCAGACATGGAGGAGGAGGAAGCCAAGAATCTGGTGAGCGAA GCCATCGCAGCTGGCATCTTCAACGACCTGGGCTCCGGAAGCAACATTGACCTCTGCGTC ATCAGCAAGAACAAGCTGGATTTTCTCCGCCCATACACAGTGCCCAACAAGAAGGGGACC AGGCTTGGCCGGTACAGGTGTGAGAAAGGGACTACTGCAGTCCTCACTGAGAAAATCACT CCTCTGGAGATTGAGGTGCTGGAAGAAACAGTCCAAACAATGGACACTTCCTGA PF00227 Proteasome component proteasome complex (sensu Eukaryota) component protein complex component proteasome core complex (sensu Eukaryota) function hydrolase activity function peptidase activity function endopeptidase activity function threonine endopeptidase activity function catalytic activity process metabolism process modification-dependent protein catabolism process ubiquitin-dependent protein catabolism process macromolecule metabolism process protein metabolism process cellular protein metabolism process proteolysis process physiological process process proteolysis during cellular protein catabolism "
rdfs:label	"(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE"
rdf:type	ns1:drugs

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/drugbank_small.nt

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