Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1004"
| Predicate | Value (sorted: default) |
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| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"route of administration: oral
study duration: 16 days
population: 9 nonsmoking, stable schizophrenic patients, physically healthy (all male)
tested for known CYP450 polymorphisms?
YES -- CYP2D6 phenotyping - all extensive metabolizers
ages: mean age 38.0 +/- 12.4
description:
SUBJECTS:Nine non-smoking stable schizophrenic patients (mean age 38.0 +/- 12.4 years and weight 59.1 +/- 12.3 kg) gave informed consent to participated in this study. Each patient met the DSM-IV criteria for schizophrenia, had not previously received CLZ or FLV and had not consumed beverages containing caffeine, alcohol or grapefruit juice for at least 1 month prior to the study. Patients were also not taking any known CYP1A2 inducers or inhibitors or other routinely prescribed medications. Only lorazepam “as needed� 2 mg every 4–6 h was allowed during the study. All patients were evaluated to be physically healthy by physical examination, medical history, and routine hematological, biochemical and urinalysis tests. These patients were not classified as refractory schizophrenics by the criteria proposed by Kane et al. (1988). Prior to the study, these patients were phenotyped with dextromethorphan and all subjects were extensive metabolizers of CYP2D6 (Lane et al. 1996). Also, prior to the study, these patients were also administered a test dose of caffeine 200 mg and CYP1A2 status was evaluated. Caffeine and metabolite ratios were within values previously reported by other investigators, indicating the absence of any unusual metabolizers of CYP1A2 in this group of patients (Bertilsson et al. 1994).
METHODS: On the first study day at 8:00 a.m., each patient received a single CLZ 50 mg dose (two 25 mg tablets). Venous blood samples (5 ml) were collected in heparinized tubes and obtained prior to the dosage administration and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 24, 36 and 48 h post-drug. The blood samples were centrifuged at 3000 rpm for 15 min and the separated plasma frozen at 920°C until assay. FLV 50 mg was administered twice a day to each patient from day 3 to day 16. On day 15, CLZ 50 mg was given as a single dose. Blood samples were obtained at the same times during the first study period.
RESULTS: The total AUC of CLZ increased by a factor of 2.84 upon FLV addition (t = 5.364, P = 0.0007)."
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| dc:creator | |
| dc:date |
"09/16/2010 14:13:21"
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| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ fluvoxamine_increases_auc_clozapine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1281 }