Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1030"

PredicateValue (sorted: none)
rdf:type
?:Evidence
rdf:type
?:Item
rdfs:label
"evidence_1664"
?:Evidence_type
?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:Evidence_enzyme_system
""
dc:creator
"boycer"
dc:date
"01132010"
?:content
"Enzyme system: human liver microsomes NADPH added: yes (a dehydrogenase generating system) probe reaction: tolbutamide --> hydroxytolbutamide Quote: CYP2C9. R-CT, S-CT, R-DCT, and S-DCT were weak inhibitors of CYP2C9, represented by tolbutamide hydroxylation, with less than 50% inhibition produced even at 250micM. R-DDCT and S-DDCT produced a moderate degree of inhibition, with IC50 values of 30.7 (+/-6.3)micM and 25.7 (+/-8.0)micM, respectively. Sulfaphenazole was a strong inhibitor (IC50 1.3micM), and the SSRI fluvoxamine also was a moderately strong inhibitor (IC50 9.4micM)."
rdfs:seeAlso
?:11454728

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ R-demethylcitalopram_does_not_inhibit_cyp2c9, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1664 }

Context graph