Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1044"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1570"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"185"
?:Evidence_enzyme_system	""
?:Evidence_type	?:Non_traceable_Drug_Label_Statement
?:claim_assumed_valid_for_evidence_application_evidence_1570	?:desipramine_primary_total_clearance_enzyme_cyp2d6
?:content	"Drugs Metabolized by Cytochrome P450IID6 (CYP2D6): Many drugs, including most antidepressants (SSRIs, many tricyclics), beta-blockers, antiarrhythmics, and antipsychotics are metabolized by the CYP2D6 isoenzyme. Although bupropion is not metabolized by this isoenzyme, bupropion and hydroxybupropion are inhibitors of the CYP2D6 isoenzyme in vitro. In a study of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150mg twice daily followed by a single dose of 50mg desipramine increased the Cmax, AUC, and t1/2 of desipramine by an average of approximately 2-, 5- and 2-fold, respectively. The effect was present for at least 7 days after the last dose of bupropion. Concomitant use of bupropion with other drugs metabolized by CYP2D6 has not been formally studied."
dc:creator	"boycer"
dc:date	"05/15/2009 10:51:26"
rdfs:seeAlso	?:c2126e2d-3b46-40dd-8168-6d0368e5d233

The resource appears as object in one triple:

{ bupropion_inhibits_cyp2d6, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1570 }

Context graph