Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1056"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1855"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"190"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Chem
?:claim_assumed_valid_for_evidence_application_evidence_1855	?:ketoconazole_in_viVo_selective_inhibitor_of_enzyme_cyp3a4
?:content	"Enzyme system: human liver microsomes NADPH added: yes (a dehydrogenase generating system) reaction: R- and S-citalopram --> R- and S- demethylcitalopram Quote: Chemical Inhibition of CT and DCT Biotransformation in Microsomes. At 10micM R- or S-CT, ketoconazole reduced reaction velocity to 55 to 60% of control, quinidine to 80% of control, and omeprazole to 80 to 85% of control (Fig. 6). When the R- and S-CT concentration was increased to 100 M, the degree of inhibition by ketoconazole increased, while inhibition by quinidine decreased (Fig. 6). These findings are consistent with the data from heterologously expressed CYP isoforms."
dc:creator	"boycer"
dc:date	"06/12/2009 19:22:19"
rdfs:seeAlso	?:11454728

The resource appears as object in one triple:

{ R-citalopram_substrate_of_cyp3a4, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1855 }

Context graph