Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1130"

PredicateValue (sorted: default)
rdfs:label
rdf:type
?:Evidence_dose
?:Evidence_enzyme_system
?:Evidence_type
?:Evidence_value
"0.000314"
?:content
"Route of administration: oral study duration: multiple dose (see quote below) population: 12 male ages:18-55 C_max = 314ng/mL 314ng/mL x 1000/1L x 1g/10^9ng = 0.000314g/L Quote: After a 2-day buildup, patients were dosed continuously with clozapine solution at three ascending dose levels (37.5, 75, and 150 mg bid for 7 days at each dose level). Following the morning administration on the twenty-third day of dosing a drug holiday was instituted which lasted for a minimum of 48 hr. Serial plasma samples were obtained during each of the periods and during the drug holiday for the calculation of the steady-state parameters AUCSS, CSSmax, and CSSmin at each dose level as well as for the assessment of the terminal elimination rate. Mean parameter values for AUCSS, CSSmax, and CSSmin showed a linearly increasing response with the dose, well described by a straight line passing through the origin."
dc:creator
dc:date
"06/15/2009 15:05:30"
rdfs:seeAlso

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ clozapine_maximum_concentration_continuous_value, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1111 }

Context graph