Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1139"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"evidence_1057"
|
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"Route of administration: oral
polymorphic enzyme: NO
study duration: 7 days pravastatin only, 8 days pravastatin and clarithromycin
dose: .040g pravastatin 1xday
.5g clarithromycin 2xday
population: 45 men and women (only 15 received pravastatin)
ages:18-60
(mean AUC_i)/(mean AUC) = 114/54
description:
Clarithromycin significantly (p <0.001) increased the AUC (and C(max)) of all 3 statins, most markedly simvastatin ( approximately 10-fold increase in AUC) and simvastatin acid (12-fold), followed by atorvastatin (greater than fourfold) and then pravastatin (almost twofold)."
|
| dc:creator | |
| dc:date |
"06/05/2007 08:33:16"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ clarithromycin_increases_auc_pravastatin, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1057 }