Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1188"
Predicate | Value (sorted: none) |
---|---|
rdf:type | |
rdf:type | |
rdfs:label | |
?:Evidence_type | |
?:Evidence_assump_list_id | |
?:Evidence_enzyme_system | |
?:claim_assumed_valid_for_evidence_application_evidence_1673 | |
dc:creator | |
dc:date |
"10/29/2007 10:11:10"
|
?:content |
"Enzyme system: human liver microsomes
NADPH added: yes
reaction: paclitaxel --> 6alpha-OH-paclitaxel
"No IC50 values could be determined for rosuvastatin and pravastatin with concentrations up to 100micM"
Concentration of pravastatin in vivo based on the largest C_max in label in table 1 of http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=1652:
3650ng/1ml x 1g/1e9ng x 1e3ml/1L = .004g/L
.004g/L x 1M/853.9g = 4.68micM/L"
|
rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ pravastatin_inhibits_cyp2c8, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1673 }