Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1238"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"route of administration: oral
study duration: a single dose of 1 mg alprazolam followed by a minimum three-day washout and then administration of 20 mg citalopram for a minimum of 21 days'
population: 10 female subjects; health state no mentioned though the study provides explicit exclusion criteria
tested for known CYP450 polymorphisms?
ages: inferred to be adults
description:
After administration with citalopram, the Tmax of alprazolam increased significantly from 0.9 +/- 0.8 to 1.4 +/-0.8 hours ( P < 0.05). There were no other significant changes in alprazolam pharmacokinetics postcitalopram as compared with precitalopram (Table 3 and Fig. 2). There was no correlation between citalopram steady-state concentration and change in alprazolam AUC."
|
| dc:creator | |
| dc:date |
"09/23/2009 12:26:47"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ citalopram_increases_auc_alprazolam, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1974 }