Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1275"
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rdf:type | |
rdf:type | |
rdfs:label | |
?:Evidence_type | |
?:Evidence_enzyme_system | |
dc:creator | |
dc:date |
"06/16/2009 18:19:35"
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?:content |
"route of administration: oral
study duration: single dose
population: 6 males
ages: 23 - 42
NMR/MS detection of metabolites
Quote:
With the help of NMR and MS data, a major metabolite of OLZ in humans was characterized as a novel tertiary N-glucuronide in which the glucuronic acid moiety is attached to the nitrogen at position 10 of the benzodiazepine ring. Another N-glucuronide was detected in urine and identified as the quaternary N-linked 4'-N-glucuronide. Oxidative metabolism on the allylic methyl group resulted in 2-hydroxymethyl and 2-carboxylic acid derivatives of OLZ. The methyl piperazine moiety was also subject to oxidative attack, giving rise to the N-oxide and N-deemethyl metabolites. Other metabolites, including the N-deemethyl-2-carboxy derivative, resulted from metabolic reactions at both the 4' nitrogen and 2-methyl groups. The 10-N-glucuronide and OLZ were the two most abundant urinary components, accounting for approximately 13% and 7% of the dose, respectively. In fecal extracts, the only significant radioactive HPLC peaks were due to 10-N-glucuronide and OLZ representing, respectively, approximately 8% and 2% of the administered dose."
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rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ olanzapine_has_metabolite_10-N-glucuronide, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1245 }