Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1283"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1734"
rdf:type	?:Evidence ?:Item
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_CT_Pharmacokinetic
?:Evidence_value	"0.4999"
?:content	"Route of administration: oral/IV study duration: on day 1 participants received either one dose of 10mgPO rosuvastatin or one IV infusion of 8mg rosuvastatin; a period of >=7 days elapsed and the participants were given the drug form that they did not receive the first time they came in to the clinic. population: 10 male ages:21-51 Description: Table 1, pg2558 shows, among other PK values, that the geometric mean of oral Cmax was 18.8ng/ml, bioavailabity (F) was calculated to be 20% of the oral dose, the hepatic extraction (E_H)ratio was .63 Based on these values the authors calculated absorbtion to be "appreciably greater than 20% and estimate it to ~50% using F/(1-E_H)."
dc:creator	"boycer"
dc:date	"09/28/2007 12:36:15"
rdfs:seeAlso	?:14667956

The resource appears as object in one triple:

{ rosuvastatin_fraction_absorbed_continuous_value, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1734 }

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