Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1296"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1685"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"224"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:claim_assumed_valid_for_evidence_application_evidence_1685	?:paclitaxel_in_vitro_probe_substrate_of_enzyme_cyp2c8
?:content	"Enzyme system: human liver microsomes NADPH added: yes reaction: paclitaxel --> 6alpha-OH-paclitaxel "No IC50 values could be determined for rosuvastatin and pravastatin with concentrations up to 100micM" Concentration of rosuvastatin in vivo based on the C_max from PMID:14667956 of a 10mg dose (small): .188nM/L; according to labeling both peak concentration (Cmax) and area under the plasma concentration-time curve (AUC) increased in approximate proportion to rosuvastatin dose."
dc:creator	"boycer"
dc:date	"10/29/2007 10:23:54"
rdfs:seeAlso	?:15998357

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ rosuvastatin_inhibits_cyp2c8, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1685 }

Context graph