Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1354"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"NOTE: The AUC_i/AUC value is from Table 1.
route of administration: oral
study duration: 8 days
population: 15 healthy subjects (11 male, 4 female), all nonsmokers; 13 Caucasian, 1 Hispanic, 1 Asian
tested for known CYP450 polymorphisms?
NO
ages: 23-40
description:
SUBJECTS: Subjects were nonsmokers who were of normal build and had no clinically significant abnormalities. Fifteen subjects (4 females and 11 males) completed the study. Thirteen subjects were Caucasian, 3 were Hispanic, and one was Asian. Ages ranged from 23 to 40 years (mean = 32 +/- 5 years). At admission, mean height was 173 +/- 10 cm and mean weight was 71 +/- 13 kg.
METHODS: The pharmacokinetics of 3 identical single therapeutic doses of olanzapine (5 mg) were determined in 15 healthy nonsmoking volunteers. The first dose of olanzapine was taken alone, the second given after a single oral dose of fluoxetine (60 mg), and the third given after 8 days of treatment with fluoxetine 60 mg, qd. There was an interval of 10 days between olanzapine doses of periods 1 and 2, and at least 15 days between olanzapine doses of periods 2 and 3. During each period, the volunteers remained in the clinical pharmacology unit for 24 hours following the administration of olanzapine.
RESULTS: After single coadministration of fluoxetine, the C_max and AUC_0-inf of olanzapine increased by 18%, whereas the total apparent clearance decreased by 15%."
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| dc:creator | |
| dc:date |
"09/16/2010 15:29:01"
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| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ fluoxetine_increases_auc_olanzapine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1443 }