Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1355"

Predicate	Value (sorted: none)
rdf:type	?:Evidence
rdf:type	?:Item
rdfs:label	"evidence_1828"
?:Evidence_type	?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:Evidence_assump_list_id	"233"
?:Evidence_enzyme_system	""
?:claim_assumed_valid_for_evidence_application_evidence_1828	?:midazolam_in_vitro_probe_substrate_of_enzyme_cyp3a4
dc:creator	"boycer"
dc:date	"09/23/2009 11:47:32"
?:content	"Enzyme system: human liver microsomes: NADPH added: yes substrate used: midazolam reaction: midazolam 1'hydroxylation IC50 > 200micM (see Table 3) Quote: Pantoprazole showed a stronger inhibitory effect (Ki 22mM) on midazolam 1'-hydroxylation than omeprazole (Ki 42micM), esomeprazole (Ki 47micM), and rabeprazole (Ki 51micM). The IC50 of lansoprazole was over 200 M."
rdfs:seeAlso	?:15258107

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ lansoprazole_inhibits_cyp3a4, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1828 }

Context graph