Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1375"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"evidence_1830"
|
| rdf:type | |
| ?:Evidence_assump_list_id |
"237"
|
| ?:Evidence_enzyme_system | |
| ?:Evidence_type | |
| ?:claim_assumed_valid_for_evidence_application_evidence_1830 | |
| ?:content |
"Enzyme system: human liver microsomes
NADPH added: yes
inhibitor used: ketoconazole
reaction: alprazolam --> 4-OH-alprazolam
alprazolam --> 1'-OH-alprazolam
ketoconazole effectively and significantly reduced the production of 4-OH-alprazolam (Ki = .046microM) and 1'-OH-alprazolam (Ki = .076microM)"
|
| dc:creator | |
| dc:date |
"07/02/2007 16:32:13"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ alprazolam_primary_metabolic_clearance_enzyme_cyp3a4, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1830 }