Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1398"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"evidence_1599"
|
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_type | |
| ?:content |
"Metabolism and Excretion
...
Thorough metabolic studies have not been conducted, but it appears that deglycination of midodrine to desglymidodrine takes place in many tissues, and both compounds are metabolized in part by the liver. Neither midodrine nor desglymidodrine is a substrate for monoamine oxidase. Renal elimination of midodrine is insignificant. The renal clearance of desglymidodrine is of the order of 385 mL/minute, most, about 80%, by active renal secretion. The actual mechanism of active secretion has not been studied, but it is possible that it occurs by the base-secreting pathway responsible for the secretion of several other drugs that are bases (see also Potential for Drug Interactions)."
|
| dc:creator | |
| dc:date |
"09/21/2009 15:09:25"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ midodrine_primary_total_clearance_mechanism_Renal_Excretion, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1599 }