Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1419"
| Predicate | Value (sorted: none) |
|---|---|
| rdf:type | |
| rdf:type | |
| rdfs:label | |
| ?:Evidence_type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_value | |
| dc:creator | |
| dc:date |
"09/22/2010 11:47:06"
|
| ?:content |
"NOTE: The AUC_i/AUC value is calculated from Table 1 using equation 1.
route of administration: oral
study duration: 7 days
population: 12 nonsmoking volunteers (all male)
tested for known CYP450 polymorphisms?
NO
ages: 22-30
description:
SUBJECTS: The study was carried out as an open, randomized, crossover study of 12 volunteers, all men with a median age of 23 years (range, 22-30 years). All were nonsmokers and had no known heart, liver, or kidney diseases according to clinical investigation, clinical chemical/hematological screening, and ECG test. They were not consuming alcohol or drugs on a regular basis at the time of the study. The volunteers consented to participate in the study on the basis of written and verbal information, and the study was approved by the regional ethics committee of the counties of Vejle and Funen and by the Danish National Board of Health.
METHODS: The volunteers were randomized into three groups. All three groups went through three testing periods, which were separated by 2 weeks of washout. In all three periods, the volunteers abstained from ingesting methylxanthine-containing beverages, foods, and medication for 3 days before study and until the last blood sample was drawn. In period A, a blood sample was drawn before intake of a tablet of 300 mg theophylline ethylenediamine (Teofylamin; Nycomed DAK, Copenhagen, Denmark), containing 257 mg theophylline. In period B, the volunteers received a tablet of 50 mg fluvoxamine (Solvay Duphar BV, Weesp, the Netherlands) for 1 day, and during the following 6 days they received 100 mg fluvoxamine each day. On day 4, a blood sample was drawn before the intake of 300 mg theophylline ethylenediamine; thereafter, blood samples were drawn at 1, 2, 3, 4, 6, 8, 12, 24, 32, 48, 72, and 96 h.
RESULTS: The total theophylline clearance was calculated as EQUATION 1 [Cl_13DMX = Dose / AUC_13DMX(total)] where Cl is clearance and AUC_13DMX(total) is the area under the plasma concentration time curve calculated by the trapezoidal rule with extrapolation from the last measurable concentration to infinity. Complete absorption of theophylline from the intestine was assumed.
See Table 1 and equation 1."
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| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ fluvoxamine_increases_auc_theophylline, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1803 }