Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1472"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"NOTE: The AUC_i/AUC value is calculated from Table 1.
route of administration: oral
study duration: 12 days
population: 19 Chinese patients diagnosed with schizophrenia or schizophreniform disorder (9 male, 10 female)
tested for known CYP450 polymorphisms?
NO
ages: 18-45
description:
SUBJECTS: Only the patients who were first-episode, had not obtained significant therapeutic effects or could not tolerate the side effects using clozapine, risperidone or any other antipsychotic drugs were enrolled in the study. In the study, 21 Chinese in-patients were involved; 2 subjects discontinued the study due to side effects of erythromycin on the digestive tract. Of the subjects who completed the study, 19 (10 females, 9 males; age 18–45 years, weight 41–60 kg) were diagnosed with schizophrenia or schizophreniform disorder (criteria of CCMD-III). They refrained from cigarettes and alcohol.
METHODS: During the first period (days 1–8), multiple and rising doses of quetiapine were given to the subjects twice daily (b.i.d). The dosage started at 25 mg b.i.d, reached 200 mg b.i.d by day 4 and remained at 200 mg b.i.d on days 5–7. Only a morning dose of quetiapine (200 mg) was given on days 8. During the second period (days 9–12), fixed doses of quetiapine (200 mg, b.i.d) and erythromycin (500 mg, three times daily) were co-administered to the subjects. A final combination dose of quetiapine (200 mg) and erythromycin (500 mg) was given in the morning of days 12.
RESULTS: For quetiapine, co-administration of quetiapine and erythromycin led to 68, 129 and 92% increases in mean C_max (P=0.001), AUC_0–inf (P=0.000) and t_1/2 (P=0.000), respectively,"
|
| dc:creator | |
| dc:date |
"09/16/2010 14:49:44"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ erythromycin_increases_auc_quetiapine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1437 }