Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1527"
Predicate | Value (sorted: default) |
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rdfs:label | |
rdf:type | |
?:Evidence_enzyme_system | |
?:Evidence_type | |
?:content |
"Enzyme system: recombinant human CYP3A5 enzymes in insect microsomes
NADPH added: yes
substrate used: atorvastatin acid and lactone
reaction:
atorvastatin acid-->ortho-hydroxy-atorvastatin
atorvastatin lactone-->ortho-hydroxy-atorvastatin
description:
According to the authors, this enzyme system catalyzed the above reactions similar to that of the CYP3A4 recombinant enzyme system whose Km was 3.9micM/L for atorvastatin lactone-->ortho-hydroxy-atorvastatin and 29.7micM/L for the atorvastatin acid-->ortho-hydroxy-atorvastatin"
|
dc:creator | |
dc:date |
"09/25/2007 08:49:18"
|
rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ cyp3a5_controls_formation_of_ortho-hydroxy-atorvastatin, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1106 }