Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/155"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1263"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"28"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:claim_assumed_valid_for_evidence_application_evidence_1263	?:bufuralol_in_vitro_probe_substrate_of_enzyme_cyp2d6
?:content	"Enzyme system: human liver microsomes: NADPH added: yes substrate used: bufuralol reaction: bufuralol 1'hydroxylation IC50 > 200micM (see Table 3) Quote: CYP2D6 Activity. No significant effects on the formation of 1 -hydroxylated bufuralol (CYP2D6) were found, indicating that none of the five PPIs [including omeprazole, lansoprazole, pantoprazole rameprazole and esomeprazole] inhibited CYP2D6 activity in vitro (IC50 200micM). However, rabeprazole thioether inhibited CYP2D6 activity with a Ki of 12micM in HLM."
dc:creator	"boycer"
dc:date	"09/23/2009 11:38:21"
rdfs:seeAlso	?:15258107

The resource appears as object in one triple:

{ omeprazole_inhibits_cyp2d6, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1263 }

Context graph