Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1550"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_type | |
| ?:content |
"Route of administration: oral
study duration: single dose with 24 hours of blood sampling
dose: single dose of 90mg diltiazem
population: 10 male, 10 female
ages:19-50
description:
Plasma concentrations and urinary excretion of DTZ and its metabolites were determined in 20 healthy volunteers (10 males and 10 females) after they had each been given a single oral 90 mg dose of DTZ. DTZ and six of its metabolites which included N-monodesmethyl DTZ (MA), deacetyl DTZ (M1), deacetyl N-monodesmethyl DTZ (M2), deacetyl O-desmethyl DTZ (M4) and deacetyl DTZ N-oxide (M1NO) and deacetyl N,O-didesmethyl DTZ (M6), were determined by a sensitive and specific HPLC assay. The major metabolites measurable in the plasma of all the volunteers were MA, M1, and M2. The terminal half-lives (t1/2) of M1 and M2 were considerably longer than those of DTZ and MA."
|
| dc:creator | |
| dc:date |
"09/24/2007 09:35:47"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ diltiazem_has_metabolite_desacetyldiltiazem, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1760 }