Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/1601"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"route of administration: don't know
study duration: not mentioned
population: 15 male subjects
tested for known CYP450 polymorphisms?
NO
ages: 19-35
DESCRIPTION:
In a study of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the Cmax, AUC, and t1/2 of desipramine by an average of approximately 2, 5 and 2 fold, respectively. The effect was present for at least 7 days after the last dose of bupropion."
|
| dc:creator | |
| dc:date |
"12/11/2012 14:18:58"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ bupropion_increases_auc_desipramine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1411 }