Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/182"
| Predicate | Value (sorted: none) |
|---|---|
| rdf:type | |
| rdf:type | |
| rdfs:label |
"evidence_1632"
|
| ?:Evidence_type | |
| ?:Evidence_enzyme_system | |
| dc:creator | |
| dc:date |
"06/16/2009 16:59:50"
|
| ?:content |
""Metabolism and Elimination Following a single oral dose of 14C labeled olanzapine, 7% of the dose of olanzapine was recovered in the urine as unchanged drug, indicating that olanzapine is highly metabolized. Approximately 57% and 30% of the dose was recovered in the urine and feces, respectively. In the plasma, olanzapine accounted for only 12% of the AUC for total radioactivity, indicating significant exposure to metabolites. After multiple dosing, the major circulating metabolites were the 10-N-glucuronide, present at steady state at 44% of the concentration of olanzapine, and 4′-N-desmethyl olanzapine, present at steady state at 31% of the concentration of olanzapine. Both metabolites lack pharmacological activity at the concentrations observed""
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ olanzapine_primary_total_clearance_mechanism_Renal_Excretion, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1632 }