Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/200"

Predicate	Value (sorted: none)
rdf:type	?:Evidence
rdf:type	?:Item
rdfs:label	"evidence_1457"
?:Evidence_type	?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:Evidence_assump_list_id	"41"
?:Evidence_enzyme_system	""
?:claim_assumed_valid_for_evidence_application_evidence_1457	?:S-mephenytoin_in_vitro_probe_substrate_of_enzyme_cyp2c19
dc:creator	"boycer"
dc:date	"06/11/2009 16:10:21"
?:content	"Enzyme system: human liver microsomes NADPH added: yes (a dehydrogenase generating system) probe reaction: S-mepheytoin 4'hydroxylation Quote: CYP2C19. R- and S-CT were very weak inhibitors, with less than 50% inhibition of S-mephenytoin hydroxylation even at 100micM. R- and S-DCT also were weak inhibitors. R- and S-DDCT were moderate inhibitors, with mean IC50 values of 18.7 and 12.1micM, respectively. Omeprazole was a strong inhibitor of CYP2C19, as was the SSRI fluvoxamine (see Table 2)."
rdfs:seeAlso	?:11454728

The resource appears as object in one triple:

{ escitalopram_inhibits_cyp2c19, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1457 }

Context graph