Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/219"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1794"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"44"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_PK_DDI_Par_Grps
?:claim_assumed_valid_for_evidence_application_evidence_1794	?:dextromethorphan_in_viVo_probe_substrate_of_enzyme_cyp2d6
?:content	"Route of administration: oral study duration: read description below population: (fluoxetine group) 14 healthy volunteers (7 male and 7 female), all extensive metabolizers of dextromethorphan ages: mean(std dev): 26 (unknown) Description: In an open label, parallel group study of 45 healthy volunteers, the time course of CYP2D6 inhibition of the above SSRIs was evaluated. Subjects were randomized to receive paroxetine at 20 mg/day for 10 days; sertraline at 50 mg/day for 3 days, followed by sertraline at 100 mg/day for 10 days; or fluoxetine at 20 mg/day for 28 days. CYP2D6 activity was assessed using the dextromethorphan metabolic ratio (DMR) on antidepressant days 5 and 10 for sertraline and paroxetine and at weekly intervals for fluoxetine. Following SSRI discontinuation, calculation of a CYP2D6 inhibition half-life (t(1/2)inh) revealed the time course of fluoxetine inhibition (t(1/2)inh = 7.0 +/- 1.5 days) to be significantly longer than either paroxetine (t(1/2)inh = 2.9 +/- 1.9) or sertraline (t(1/2)inh = 3.0 +/- 3.0) (p < 0.01), but the latter were not significantly different from each other (p > 0.05). Time for the extrapolated DMR versus time log-linear plots to return to baseline was significantly different between fluoxetine (63.2 +/- 5.6 days) and both paroxetine (20.3 +/- 6.4 days) and sertraline (25.0 +/- 11.0 days) (p < 0.01), making the rank order (from longest to shortest) of time for CYP2D6 inhibition to dissipate: fluoxetine > sertraline >or= paroxetine. Differences between mean baseline DMR values and measured values obtained after drug discontinuation for each drug group became nonsignificant on discontinuation day 5 for both paroxetine and sertraline and on discontinuation day 42 for fluoxetine."
dc:creator	"boycer"
dc:date	"05/05/2009 17:04:02"
rdfs:seeAlso	?:11910262

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ fluoxetine_inhibits_cyp2d6, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1794 }

Context graph