Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/248"

PredicateValue (sorted: default)
rdfs:label
"evidence_1764"
rdf:type
?:Evidence
?:Item
?:Evidence_enzyme_system
""
?:Evidence_type
?:EV_EX_Met_Enz_ID_Cyp450_Hum_Recom
?:content
"Enzyme system: For CYP1A2 - recombinant CYP450 enzymes expressed in an human lymphoblastoid cell system. For CYP2C9, 2C19,2D6, and 3A4 - recombinant CYP450 enzymes expressed in insect cells NADPH added: yes reaction: 1) ziprasidone --> ziprasidone sulphoxide 2) ziprasidone --> ziprasidone sulphone Quote: "The ability of specific CYP isoforms to metabolize ziprasidone was determined using recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4. H.p.l.c.-radioactivity profiles of ziprasidone metabolites following incubation of [14C]-ziprasidone or [3H]-ziprasidone with CYP3A4 are shown in Figure 5(a) and (b), respectively. CYP3A4 catalysed the formation of the N-dealkylated metabolite (M5), as well as ziprasidone sulphone (M8) and ziprasidone sulphoxide (M10). These oxidative metabolites were not detected in incubations containing recombinant CYP1A2, CYP2C9, CYP2C19 or CYP2D6.""
dc:creator
"boycer"
dc:date
"01132010"
rdfs:seeAlso
?:10771452

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ ziprasidone_is_not_substrate_of_cyp3a4, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1764 }

Context graph