Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/308"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"Route of administration: oral
study duration: four days pre-treatment with itraconazole
population: male: 2 female: 7
ages: 19-26
NOTE: AUC data taken from table 1 AUC_i/AUC:42/3.9
Interaction between ketoconazole, itraconazole, and midazolam was investigated in a double-blind, randomized crossover study of three phases at intervals of 4 weeks. Nine volunteers were given either 400 mg ketoconazole, 200 mg itraconazole, or matched placebo orally once daily for 4 days. On day 4, the subjects ingested 7.5 mg midazolam. Plasma samples were collected and psychomotor performance was measured. Both ketoconazole and itraconazole increased the area under the midazolam concentration-time curve from 10 to 15 times (p < 0.001) and mean peak concentrations three to four times (p < 0.001) compared with the placebo phase."
|
| dc:creator | |
| dc:date |
"06/05/2007 14:37:35"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ itraconazole_increases_auc_midazolam, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1578 }