Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/317"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1145"
rdf:type	?:Evidence ?:Item
?:Evidence_enzyme_system	""
?:Evidence_type	?:Non_traceable_Drug_Label_Statement
?:content	"Metabolism and elimination � ... The major oxidative metabolite formed, regardless of CYP2D6 status, is 4�hydroxyatomoxetine, which is glucuronidated. 4�Hydroxyatomoxetine is equipotent to atomoxetine as an inhibitor of the norepinephrine transporter but circulates in plasma at much lower concentrations (1% of atomoxetine concentration in EMs and 0.1% of atomoxetine concentration in PMs). 4�Hydroxyatomoxetine is primarily formed by CYP2D6, but in PMs, 4�hydroxyatomoxetine is formed at a slower rate by several other cytochrome P450 enzymes. N�Desmethylatomoxetine is formed by CYP2C19 and other cytochrome P450 enzymes, but has substantially less pharmacological activity compared with atomoxetine and circulates in plasma at lower concentrations (5% of atomoxetine concentration in EMs and 45% of atomoxetine concentration in PMs)."
dc:creator	"boycer"
dc:date	"09/24/2009 11:29:56"
rdfs:seeAlso	?:309de576-c318-404a-bc15-660c2b1876fb

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ atomoxetine_has_metabolite_N-desmethylatomoxetine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1145 }

Context graph