Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/34"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1446"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"8"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Chem
?:claim_assumed_valid_for_evidence_application_evidence_1446	?:ketoconazole_in_vitro_selective_inhibitor_of_enzyme_cyp3a4
?:content	"Enzyme system: human liver microsomes: NADPH added: yes inhibitor used: ketoconazole reaction: citalopram --> desmethylcitalopram Quote: Ketoconazole produced concentration-dependent inhibition of DCT formation (Figure 4). The mean (+/-SE) IC50 values for ketoconazole were 0.81 (+/-.24) micM/L at CT = 10 micM/L, and 1.54 (+/-.35) micM/L CT = 100 micM/L; these values were not significantly different."
dc:creator	"boycer"
dc:date	"02/12/2010 18:35:58"
rdfs:seeAlso	?:10494454

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ cyp3a4_controls_formation_of_desmethylcitalopram, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1446 }

Context graph